What Does Serum Adiponectin Portend in Obese Nigerian Type 2 Diabetes Subjects

Authors

  • O.O. Ezekpo Dept of Medicine, Afe Babalola University Ado Ekiti & Multi-System Hospital Ado Ekiti Nigeria
  • R.T. Ikem Dept of Medicine, Obafemi Awolowo University Ile Ife, Nigeria
  • B.A. Kolawole Dept of Medicine, Obafemi Awolowo University Ile Ife, Nigeria
  • D.O. Soyoye Dept of Medicine, Obafemi Awolowo University Ile Ife, Nigeria
  • G.O. Ajani Dept of Medicine, Afe Babalola University Ado Ekiti & Federal Teaching Hospital Ido Ekiti, Nigeria

Keywords:

Serum adiponectin, obese type 2 diabetes, glycaemia, lipid profile

Abstract

Background: Adiponectin is a protein hormone whose levels have been found to correlate with glycaemic control and lipid profile in patients with Type 2 DM. This study evaluates the relationship of adiponectin in Obese and non - obese Nigerian T2DM patients.

Method: This cross-sectional hospital-based study included two groups of 60 Obese T2DM and 60 non-obese T2DM subjects. All study participants had clinical assessment, and blood samples collected and assessed  for serum Adiponectin, fasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein.

Results: Obese T2DM subjects had lower levels of adiponectin than Non-obese T2DM subjects (p > 0.05). In both groups, 65% and 77% of the Obese non-Obese diabetic group had good glycemic status, which poorly correlated with serum adiponectin levels, with higher adiponectin values seen in the groups with poorly controlled glycemic status.

High density lipoprotein cholesterol (HDL-C) levels correlated positively with serum Adiponectin levels in both Obese and non-Obese diabetic groups, however this was significant only in the Obese diabetic group (r = 0.30, p = 0.02). Adiponectin correlated negatively with Triglycerides only in the non-Obese diabetic group (r = -0.12, p = 0.37), and also correlated negatively with atherogenic index (r = -0.092, p = 0.316), though not statistically significant.

Conclusion: Adiponectin  is a poor marker for glycaemic control, and does not correlate with lipids such as TG, through its anti-atherogenic properties it may be associated with reduced risk of atherosclerosis as evidenced by its weakly positive and direct correlation with HDL among Nigerian Type 2 DM subjects.

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Published

2022-09-16

How to Cite

O.O. Ezekpo, R.T. Ikem, B.A. Kolawole, D.O. Soyoye, & G.O. Ajani. (2022). What Does Serum Adiponectin Portend in Obese Nigerian Type 2 Diabetes Subjects. International Journal of Sciences: Basic and Applied Research (IJSBAR), 63(2), 320–329. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14514

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