International Journal of Sciences: Basic and Applied Research (IJSBAR)

Assessing the Role of the Interleukin-12/STAT4 Axis in Breast Cancer by a Bioinformatics Approach

Angel Núñez-Marrero — Thu, 22 Aug 2019 19:45:22 +0000

Interleukin-12 (IL-12) is an anti-tumor cytokine that promotes biological actions through the IL-12/STAT4 axis. Genetic variation and tumor microenvironment dynamics have been identified as critical elements for impaired immune anti-tumor responses. Breast cancer (BC) is a heterogeneous disease classified at the molecular level in several subtypes, each having unique biological and clinical traits. Despite research identifying the relevance of IL-12 in many cancer types, no studies have assessed the role of the IL-12/STAT4 axis in BC. The goal of this study was to evaluate the correlation of the IL-12/STAT4 signaling axis and BC patients’ survival in general and in the context of the BC molecular subtypes. Bioinformatics analyses using TCGA data were completed to evaluate the correlation of the IL-12/STAT4 axis and BC. A high expression of important IL-12/STAT4 axis molecules such as the IL-12 receptor genes (IL12RB1 and IL12RB2), STAT4, IFNG and TBX21 were found to significantly increase BC patients’ survival rates, especially in the most aggressive BC subtypes such as the luminal B (LumB), HER-2+ and basal like (BL). A possible relevant role of the IL-12/STAT4 axis in BC is suggested by this bioinformatics-study, which might also be subtype-specific. Further studies such as molecular and tumor microenvironment analyses will be required to clarify better the specific role of the IL-12 /STAT4 axis in BC. The results from these additional analyses may potentially improve IL-12 related immunotherapeutic approaches to BC.

A Study of Relationships between Perceived Value, Perceived Price, Perceived Quality and Trust toward Purchase Intention of Timeshare Ownership among Tourists in Bangkok

Luo Zuo — Thu, 22 Aug 2019 19:20:52 +0000

The vacation ownership and timeshare industry has emerged as a sector of the travel industry with significant opportunities for growth and development. The aim of this research was to study the relationship and influence of perceived value, perceived quality, perceived price and trust on purchase intention of timeshare ownership. In additional, the objectives also were to determine the most influential factors of timeshare ownership purchase intention. The data was collected from 420 tourism among three Bangkok shopping area. The Multiple Linear Regression (MLR) Model and coefficient table was used to the hypotheses. The results of this research showed that all four independent variables have influence in the timeshare ownership purchase intention. Among which, the perceived price contributes highest level of influence on timeshare ownership purchase intention. The findings can serve as a guideline for the company to adjust this product as well as selling process. In order to attract potential customers to participate on product selling and make final deal.

Microbic Biotechnology in the Making of Organic Fertilizer and its Role on Soil and Cocoa Plants

Thu, 22 Aug 2019 18:51:01 +0000

One of the problems that is often encountered in mineral soils that have a low pH is the content of organic matter and low soil nutrient status. Organic matter is very important because it is able to improve the physical, chemical and biological properties of the soil. Organic wastes cannot be directly utilized by plants and must be composted first by soil microorganisms into nutrients that can be absorbed by plants. The use of microorganisms and organic matter in agriculture is done because it can increase the availability of nutrients in the soil and its absorption for plants and form soil structures to become more loose, reduce the weight of clay-textured soil and increase the amount and biological activity of the soil which synergistically can increase seedling plant growth. This research was carried out in Lima Puluh Koto district of West Sumatra Province for 8 months from March to October 2018. The purpose of this study was to obtain the most appropriate dosage tithonia of compost and microorganisms to increase cocoa plant production. The design used in factorial randomized block design with DMNRT follow-up at a level of 5%, consisting of 2 factors, the first factor was the dose of Tithonia compost and the second factor was the dose of Pseudomonas fluorescens + Trichoderma harzianum microorganisms. responses from parameters observed were N, P, and K soil and plants, as well as the average weight of wet cocoa beans per plant. The results showed no interaction between compost tithonia and Pseudomonas fluorecens and Tricoderma harzianum microorganisms on all response parameters in cocoa plants.

But the administration of compost tithonia and Pseudomonas fluorecens and Tricoderma harzianum has an effect on all response parameters in cocoa plants. The administration of Tithonia compost was obtained in the treatment of 10 kg / plant and microorganisms at a dose of 400 ml Pseudomonas fluorecens + 4 kg Tricoderma harzianum.

Determining Dominant Physical Factors in Sepak Takraw Service Capabilities

Saharuddin Ita — Tue, 20 Aug 2019 07:00:17 +0000

A service technique is an important element in the game of sepak takraw because it is the initial kick made by servers towards the opponent's field as a sign of starting the game. Good service is difficult for opponents to return the ball so that points can be achieved by the server's team. The purpose of this study was to determine the dominant physical factors determining the ability of sepak takraw service. The method used was a correlational study with multiple linear regression analysis. The sampling technique in this study was purposive sampling involving 100 students. This study was carried out from 7th to 13th October 2015 at the Jayapura Sports Building, University of Cenderawasih. The variables of this research were leg length, body weight, core flexibility, leg power, balance and service capability with the formula Y = a + b1X1 + b2X2 + b3X3 + b4X4 + b5X5. In conclusion, the dominant physical factor in the sepak takraw service capability was the leg muscle power variable (X3), because the leg muscle power had the highest standardized coefficient beta value (0.230) compared to other variables.

Modulo 10 Error Detection Efficiency Analysis for Bank Routing Number

Nyagah Macharia, Waweru Kamaku, Joy Mutegi, Sitawa Wattanga — Sun, 18 Aug 2019 13:03:40 +0000

The Routing number is a nine-digit code used to identify specific banks and their transactions uniquely. Electronic Funds Transfer Routing Number Scheme is used to calculate the ninth digit of the routing number commonly known as the check digit. Fraud and insecurity cases associated with the banking sector necessitated the need to analyze the routing number scheme capabilities in error detection and correction. This paper discusses some of the significant limitations in the code as well as some of the code design shortfalls affecting the code’s error detection and correction. It is then shown that there is a need for the design of a new code that improves the error detection of the routing number code.