Association between Transaminitis and Myositis among Patients with COVID-19: A Case- Control Study

Authors

  • Iszaid Idris Hospital Pontian, Jalan Alsagoff, 82000 Pontian, Johor, Malaysia
  • Faez Azhan Hospital Pontian, Jalan Alsagoff, 82000 Pontian, Johor, Malaysia
  • Nur Madhiah Mohd Mohdi Hospital Pontian, Jalan Alsagoff, 82000 Pontian, Johor, Malaysia

Keywords:

COVID-19, Transaminitis, Myositis, Hospital Pontian

Abstract

Introduction: COVID-19 has brought about a major health burden globally. There are little to no attention has been paid to muscle-related complication in patient with COVID-19. Elevated liver enzymes together with the presence of comorbidities in COVID-19 patients render greater risk for morbidity and mortality, and the phenomenon may be related to Myositis. This study aimed to describe the association between transaminitis and myositis in patients hospitalised with COVID-19 at Hospital Pontian (Malaysia). Methods: This is an observational case-control study involving patient with myositis, hospitalised due to COVID-19 infection. Descriptive and inferential statistics were computed to analyse the data. Results: Total of 60 patients by ratio of 1:1, sex-matched, were included in this study. Elevated AST (86%, p=0.037) and ALT (66.7%, p=0.038) were shown significantly more common in patients with elevated CK compared to control. Discussion:  The incident rate for myositis among hospitalised COVID-19 patient was reported to be approximately 9.7%. Normal liver biomarkers such as: alkaline phosphatise, total protein and bilirubin may potentially suggest the release of ALT and AST occurs from an origin other than liver tissue. Multiorgan failure may not necessarily be the cause of myositis among patients with COVID-19. Conclusion: This study indicates that myositis in patients with COVID-19 is not an uncommon occurrence.

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Published

2022-08-21

How to Cite

Iszaid Idris, Faez Azhan, & Nur Madhiah Mohd Mohdi. (2022). Association between Transaminitis and Myositis among Patients with COVID-19: A Case- Control Study. International Journal of Sciences: Basic and Applied Research (IJSBAR), 63(2), 132–139. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14425

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