Transition Metals-Amine Derivative Complexes with their Preparation, Characterization and Antimicrobial Evaluation
Keywords:antimicrobial activities, Schiffâ€™s base ligand, aminophenol, transition metal complexes.
This paper reports the synthesis, characterization and antimicrobial evaluation of complexes prepared from different transition metals and Schiff’s base ligand, 3-methoxy-4-hydroxyphenylmethyelene(2-hydroxyphenyl)amine synthesized from vanillin and 2-aminohpenol. The structural features of the resulting complexes and ligands were characterized by elemental analysis, magnetic susceptibility, molar conductance, Fourier Transform-Infra Red, UV-Vis (electronic spectra), and Atomic absorption spectroscopic methods. The FT-IR spectral data indicated the coordination of phenolic oxygen and azomethane nitrogen to the central metal ions. The results of electronic spectral studies and magnetic susceptibility measurements suggested an octahedral geometry for Zn(II), Ni(II), Cr(III), and Fe(III) complexes but square planar for Cu(II) complex. The ligands and their complexes were screened in-vitro for their antibacterial and antifungal activities against bacterial strains, (Escheria coli and Staphylococcus aureus) and fungal strains (Aspergillus niger and Colletotrichum gloeosporioides). The results demonstrated that the free ligand showed higher activities than the corresponding complexes in both bacteria and fungi, and comparable with the standard, suggesting the potential of the ligand for the use of antimicrobial test.
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