Reduction of 223Ra retention in the Large Intestine During Targeted Alpha Therapy with 223RaCl2 by Oral BaSO4 Administration in Mice

Authors

  • Sayaka Hanadate National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan Faculty of Science, Toho University, Chiba 274-8510, Japan
  • Yukie Yoshii National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
  • Kohshin Washiyama Faculty of Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan Advanced Clinical Research Center, Fukushima Medical University, Fukushima 960-1295, Japan
  • Mitsuyoshi Yoshimoto Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba 277-8577, Japan
  • Tomoo Yamamura Institute for Materials Research, Tohoku University, Sendai 980-8579, Japan Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan
  • Makoto Watanabe Institute for Materials Research, Tohoku University, Sendai 980-8579, Japan
  • Hiroki Matsumoto Nihon Medi-Physics Co., Ltd., Chiba 299-0266, Japan
  • Mineko Igarashi National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
  • Atsushi B Tsuji National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
  • Tatsuya Higashi National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan

Keywords:

targeted alpha therapy, 223Ra, BaSO4, large intestine, radiation exposure.

Abstract

Background: Targeted alpha therapy with 223RaCl2 is used to treat skeletal metastases of hormone-refractory prostate cancer. The intravenous injection of 223RaCl2 causes gastrointestinal disorders such as nausea, abdominal discomfort, and diarrhea as frequent clinical adverse events caused by radiation. BaSO4 is known to display Ra2+ ion uptake in its structure and is clinically used as a contrast agent for X-ray imaging following oral administration. Here, we investigated the feasibility of a method to reduce 223Ra retention in the large intestine with BaSO4 by biodistribution studies in mice. Methods: 223RaCl2 biodistribution was examined in ddY mice after intravenous administration (10 kBq/mouse).

BaSO4 (100 mg/mouse) was orally administered 1 h before 223RaCl2 injection. We also investigated the effect of laxative treatment on BaSO4 activity, since laxatives are clinically used with BaSO4 to avoid impaction in the large intestine. Results: BaSO4 significantly reduced 223Ra retention in the large intestine after 223RaCl2 injection in mice when compared with the control without BaSO4 administration (P < 0.05). Excretion of 223Ra into the feces was significantly increased by BaSO4 administration (P < 0.05). Laxative treatment did not affect BaSO4 activity in reducing 223Ra retention, although no additional effect of laxative treatment to 223Ra excretion was observed in mice. Conclusions. BaSO4 administration was effective in reducing 223Ra retention in the large intestine during 223RaCl2 therapy, and laxative treatment did not attenuate BaSO4 activity. This method could be useful in reducing adverse events caused by radiation exposure to the large intestine during 223RaCl2 therapy.

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Published

2018-10-26

How to Cite

Hanadate, S., Yoshii, Y., Washiyama, K., Yoshimoto, M., Yamamura, T., Watanabe, M., Matsumoto, H., Igarashi, M., B Tsuji, A., & Higashi, T. (2018). Reduction of 223Ra retention in the Large Intestine During Targeted Alpha Therapy with 223RaCl2 by Oral BaSO4 Administration in Mice. International Journal of Sciences: Basic and Applied Research (IJSBAR), 42(2), 95–105. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/9429

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Vol. 42 No. 2 (2018)

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