The Ability of Namnam (Cynometra cauliflora) Leafs Extract as Antidiabetic Agent Through ?

Authors

  • La Ode Sumarlin Doctoral Students of the Major Sciences Physiology and Efficacy of Medicines The Graduate School of Bogor Agicultural University, Dramaga, Bogor, 16680, Indonesia Departmen of Chemistry, Faculty of Science and Technologi, Syarif Hidayatullah State Islamic University (UIN) Jakarta, Ciputat, 15412, Indonesia
  • Agik Suprayogi Programme Major Sciences Physiology and Efficacy of Medicines, The Graduate School of Bogor Agicultural University, Dramaga, Bogor, 16680, Indonesia
  • Min Rahminiwati Programme Major Sciences Physiology and Efficacy of Medicines, The Graduate School of Bogor Agicultural University, Dramaga, Bogor, 16680, Indonesia
  • Aryani Satyaningtijas Programme Major Sciences Physiology and Efficacy of Medicines, The Graduate School of Bogor Agicultural University, Dramaga, Bogor, 16680, Indonesia
  • Dede Sukandar Departmen of Chemistry, Faculty of Science and Technologi, Syarif Hidayatullah State Islamic University (UIN) Jakarta, Ciputat, 15412, Indonesia
  • Achmad Tjachja Departmen of Agribussines, Faculty of Science and Technologi, Syarif Hidayatullah State Islamic University (UIN) Jakarta, Ciputat, 15412, Indonesia
  • Harni Pangestika Departmen of Chemistry, Faculty of Science and Technologi, Syarif Hidayatullah State Islamic University (UIN) Jakarta, Ciputat, 15412, Indonesia

Keywords:

?-glucosidase, Antidiabetic, Cynometra cauliflora, Extraction, Namnam .

Abstract

The prevalence of patients with Diabetes Mellitus (DM) is increasing dramatically worldwide. One therapeutic approach to treat diabetes by inhibiting the absorption of glucose through inhibiting ?-glucosidase. Plant that is potential for this benefit is namnam (Cynometra cauliflora). ?-glucosidase inhibitory activity of namnam leafs extract (Cynometra cauliflora) can be tested at various stages of extraction such as maceration with methanol, liquids extraction (solvent: n-hexane, ethyl acetate and n-butanol), and column chromatography. ?-glucosidase inhibitory activity was tested in vitro using a p-nitrophenyl- ?-D-glucopyranoside (PNPG) as a substrate.

The analysis showed that the IC50 value at maceration stage with methanol is 5.58

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Published

2016-10-22

How to Cite

Sumarlin, L. O., Suprayogi, A., Rahminiwati, M., Satyaningtijas, A., Sukandar, D., Tjachja, A., & Pangestika, H. (2016). The Ability of Namnam (Cynometra cauliflora) Leafs Extract as Antidiabetic Agent Through ?. International Journal of Sciences: Basic and Applied Research (IJSBAR), 30(2), 112–123. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/5720

Issue

Vol. 30 No. 2 (2016)

Section

Articles

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