Activity of MG-192 Against in Vitro Cultures of Infective Trypanosome Species and its Acute Toxicity Effects in Mice.

Authors

  • Maureen Kamau College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, P.O.Box 62000-00200, Nairobi, Kenya.
  • Joanna Auma Biotechnology Research Institute- KARLO, P. O. Box 32-00902, Kikuyu, Kenya.
  • Monica Maichomo Biotechnology Research Institute- KARLO, P. O. Box 32-00902, Kikuyu, Kenya
  • Jesca Wesonga College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, P. O. Box 62000-00200, Nairobi, Kenya.
  • Joseph Chege Sun Jose Medical Clinic, P. O. Box 33311-00600, Nairobi, Kenya.
  • Eric Lelo Centre for Biotechnology Research & Development-KEMRI, P. O. Box 54840-00200, Nairobi, Kenya.

Keywords:

Trypanosomiasis, structure-activity relationship theory, MG-192, drug development, in vitro efficacy, acute toxicity.

Abstract

Trypanosomiasis is a disease caused by parasites of the Trypanosoma genus. The parasites are transmitted by the bite of an infected tsetse fly, resulting in human and animal disease.

References

. P.P. Simarro, G. Cecchi, J.R. Franco et al. (2012, Oct).

. G. Zeleke. (2011, Jul.).

. C. Bacchi (2009, April).

. P. Babokhov, A. Sanaolu, W. Oyibo et al. (2013, Jul).

. J.D. Mckinney, A. Richard, C. Waller et al. (2000, Jul.).

. E. Fink and H. Schmidt.

. C.J. Bacchi, H.C. Nathan, N. Yarlett et al. (1994, Mar.).

. J.M. Kagira and N.W. Maina.

. M.A. Gray and A.S. Peregrine.

. N. Maina, J.M. Kagira, P. Maser et al.

. W.J. Herbert and W.H.R. Lumsden.

. T. Baltz, D. Baltz, C.H. Giroud et al.

. M.C. Eisler, J. Brandt, B. Bauer et al.

. J. Naessens, H. Kitani, Y. Nakamura et al. (2005, Mar.).

. World Health Organization website. http://www.who.int/trypanosomiasis_african/diagnosis/en/. [Nov. 18, 2014].

. R. Brun, R. Don, RT Jacobs et al. (2011, Jun.).

Downloads

Published

2016-03-14

How to Cite

Kamau, M., Auma, J., Maichomo, M., Wesonga, J., Chege, J., & Lelo, E. (2016). Activity of MG-192 Against in Vitro Cultures of Infective Trypanosome Species and its Acute Toxicity Effects in Mice. International Journal of Sciences: Basic and Applied Research (IJSBAR), 25(3), 315–323. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/5277

Issue

Vol. 25 No. 3 (2016)

Section

Articles

License

Authors who submit papers with this journal agree to the following terms.