Partial Hydatidiform Mole Complicated by Multinodular Goiter. A Case from Bulgaria

Abstract

Partial mole occurs when an egg is fertilized by two spermatozoids or by one spermatozoid which reduplicates itself yielding most commonly triploid genotype of 69,XXY. We present a case of a partial hydatidiform mole associated with multinodular goiter. The patient is a 27-year-old primigravida who presented for termination of non-viable pregnancy at 11 weeks gestation. Her ultrasound examination showed lack of growth and presence of degenerative changes. Thyroid gland ultrasound scan revealed multinodular goiter. Flow cytometry analysis showed triploid pick index of 1.46 which confirmed the triploid karyotype (69, ???) detected by genetic studies. Partial hydatidiform mole could be a risk factor for the occurrence of nodular goiter and even hyperthyroidism as the underlying hormonal imbalance triggers pathogenetic mechanisms of the thyroid dysfunction.