Polymorphism in the Promoter Region of MIF and Risk of Bladder Cancer in Iraqi Patients
Keywords:
MIF Polymorphism, Bladder cancer.Abstract
This study was aimed to investigate gene polymorphism of macrophage migration inhibitory factor (MIF) at -173 locus as risk factor of bladder cancer in Iraqi population by PCR-RFLP. Accordingly 135 Iraqi Arab subjects were distributed as 73 patients with urinary bladder carcinoma (UBC), 32 patients with urinary bladder disorders and 30 healthy control. The frequency distributions of genotypes and alleles of the groups showed the GG and G allele were (61.9 and 78.77) % among the UBC cases with positive association with no significant relative risk (RR) value1.41 and etiological factor (EF) value of 0.18 and (56.3 and 75)% among the UBD cases while represent (53.3and 70)% respectively among healthy cases and no significant variation was recorded between UBC and control.
References
. Chan, K.; Espinosac , L.; Chaoa, M.; Wongd, D.; Aillesa, L.; Diehna, M. and H.,Gi(2009). "Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells" PNAS ,vol.106 ( 3),pp. 14016
. Akli, S.; Zhang, X.; Bondaruk, J.; Tucker, S., Czerniak, P.; Benedict, F.and K., Keyomarsi(2012)."Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer" Cell Cycle, vol.11(7),pp. 1468-1476.
. Dejong, Y.; Pinckaers, J.; Brinck, R.; Nijeholt, A. and D., OM (2014). "Urinating Standing versus Sitting: Position Is of Influence in Men with Prostate Enlargement. A Systematic Review and Meta-Analysis." PLOSONE,vol.9 (7),pp.e101320.
. Miremami, J. and N., Kyprianou (2014)."The Promise of Novel Molecular Markers in Bladder Cancer". International Journal of Molecular Science, vol. 15(12),pp. 23897
. Xue, Y.; Xu, H. and L., Rong (2010). "The MIF -173G/C polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population" Leukemia Research, vol.34, pp.1282-1286.
. Shimizu,T(2010). "The Role of Macrophage Migration Inhibitory Factor (MIF) in Ultraviolet Radiation-Induced Carcinogenesis" Cancers ,vol.2,pp.1555-1564.
. Spoorthy, N .; Chetal, G. and S., Kumar(2012). "Macrophage Migration Inhibitory Factor: a Potential Marker for Cancer Diagnosis and Therapy". Asian Pacific Journal of Cancer, vol. 13, pp.1737-1744.
. Yuan , T.; Tang , C.; Chen ,M.; Deng,C. and P. ,Chen(2013). "Influence of the human MIF promoter polymorphism on hepatocellular carcinoma prognosis". Genetic and Molecular Research, vol. 12 (4),pp. 6629-6635.
. Meyer-Siegler, K.; Vera, P.; Iczkowski, K.; Bifulco, C.; Lee, A.;Gregersen, P.; Leng, L. and R., Bucala (2007). "Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated withincreased prostate cancer incidence". Genes Immunity, vol. 8,pp.646
. Souza,M.; Curioni , O.; Kanda, J. and M.,De Carvalho (2014)."Serum and salivary macrophage migration inhibitory factor in patients with oral squamous cell carcinoma" .Oncology Letters, vol. 8 (5),pp. 2267-2275.
. Liu, Y. and J., Lin (2014). "Recent advances of cluster of differentiation 74 in cancer". World Journal of Immunology , vol.4(3),pp. 174-184.
. Morris, K.; Nofchissey, R.; Pinchuk, I. and E., Beswick (2014). "Chronic Macrophage Migration Inhibitory Factor Exposure Induces Mesenchymal Epithelial Transition and Promotes Gastric and Colon Cancers". PLOS ONE, vol. 9 ( 6 ),pp.1-10.
. Kwok,P and X., Chen(2003). "Detection of Single Nucleotide Polymorphisms". Molecular Biology,vol. 5,pp. 43-60.
. Cardiol, R.( 2014)."Genes polymorphism in Human" . Human Gene, vol.22(1),pp.1-12.
. Hosgood, H.; Menashe, I. and M., Shen (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis ,vol.29,pp. 1938
. Michiels, S.; Laplanche, A. and T.,Boulet (2009). "Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk". Carcinogenesis , vol. 30,pp.763
. Wu, P. and C., Shen(2011)."Hide-then-hit
. Orita, M.; Iwahana, H.; Kanazawa, H.; Hayashi, K. and T.,Sekiya (1989). "Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms". Proc. Natd. Acad. Sci. USA .,86: 2766-2770.
. Kaur, G and N., Mehra (2012). "Cytokine gene polymorphisms: methods of detection and biological significance". Methods of Molecular Biology, vol. 882 (10),pp.549-568.
. Birdsell, D. N.; Pearson, T.; Price, E. P.; Hornstra, H. M.; Nera, R. D and N., Stone. (2012). "Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models". PloS One.,vol. 7(3),pp. e32866-e32872.
. Berno, G.; Zaccarelli, M.; Gori, C.; Tempestilli, M.; Antinori, A.; Perno,L.; Pucill C.; and R., D
. Yuan, Q.; Meilin, W.; Miaomiao, W
. Yaun , T.; Tang, C.; Chen, M.; Deng,S. and P., Chen(2013)."Influence of the Human MIF promoter Polymorphism on hepatocellular carcinoma prognosis" Genetics and Molecular Resraech, vol.12(4),pp:6629-6635.
. Das, R.; Subrahmanyan, L.; Ivana, V. ; Duin, D.; Levy, R.; Piecychna, M.; Leng, L.; Ruth ,R.; Shaw, A.; Schwartz, D. and R., Bucala(2014). "Functional Polymorphisms in the Gene Encoding Macrophage Migration Inhibitory Factor Are Associated With Gram-Negative Bacteremia in Older Adults". The Journal of Infectious Diseases ,vol.,209,pp.764
. Zhang,X.; Weng,W.; Xu,W.; Wang,Y.; Yu,W.;Tang,Y.; Pan,Q.; Wang,J. and F.,Sun(2015). "The association between the migration inhibitory factor ?173G/C polymorphism and cancer risk: a meta-analysis" Cancer,vol. 8,pp. 601
. Nishihira,J.;Sato,Y.;Ishibashi,T.;Fukushima,T.;Sun,B.andS.,Todo(2003)."Macrophage Migration Inhibitory factor (MIF)".Ann.N.Y.Acad.Sci.,995:171-182.
. Arikan, C.; Berdeli,A.; Ozgenc, F.; Tumgor, G.; Yagci, R. and S., Aydogdu (2006). "Positive association of macrophage migration inhibitory factor gene-173G/C polymorphism with biliary atresia". J Pediatr Gastroenterol Nutr.,vol. 42,pp.77
. Makhija, R.; Kingsnorth, A. and A., Demaine A (2007)."Gene polymorphisms of the macrophage migration inhibitory factor and acute pancreatitis". Jop., 8:289
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