Detection of Five Novel Mutations in K-ras Gene for Iraqi Patients with Bladder Cancer

Authors

  • Abdul Hussein AlFaisal Institute of Genetic Engineering and Biotechnology-University of Baghdad, Baghdad, Iraq
  • Mustafa Akeel Nafeh

Keywords:

Bladder carcinoma, K-ras, RFLP, g.28542 del G, g.28543 A>C, g.28544 A>C, g.28532-33 AT>TG.

Abstract

The present study was carried out in Genetic Engineering and biotechnology Institute

Author Biography

Abdul Hussein AlFaisal, Institute of Genetic Engineering and Biotechnology-University of Baghdad, Baghdad, Iraq

Genetic Engineering Dept. Prof.Dr., The Dean

References

Li S, Peng Q, Chen Y, Pengyou J, Chen Z, Deng Y, et al. DNA repair gene XRCC1 polymorphisms, smoking and bladder cancer risk: Ameta-analysis. PLOS One. 2013; 8 (9): 1-14.

Jemal A, Siegel R, Ward E, Hao Y, Xu J, and Thun MJ. Cancer statistics, 2009. C.A. Cancer J. Clin. 2009; 59 (4): 225-249.

Hattori S, Kojima K, Minoshima K, Yamaha M, Horie M, Sawamura T, et al. Detection of bladder cancer by measuring CD44v6 expression in urine with real-time quantitative reverse transcription polymerase chain reaction. Urology. 2014; 83 (6): 1443. 9-15.

Karagas MR, Tosteson JS, and Morris JS. Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire, cancer causes and control. 2004; 15: 465-72.

Oeggerli M, Riedholz A. E2F3 is responsible for frequent amplification of 6p22.3 in human bladder cancer. 2005; 8-9.

Ministry of health, Iraqi Cancer Board. (2014). Results of Iraqi cancer registry 2011.

Brandau S, B

AL-Faisal AHM, Kraidi AM, Suleiman AA. Detection of Codon 12/13 g.6262G>A mutation of H-ras gene in Iraqi Bladder carcinoma patients. Iraqi Journal of Biotechnology. 2015; 14 (1): 44-52.

Al-Faisal AM, Bresam S. Detection of three novel mutations in exon 7 of FGFR3 gene in Iraqi patients with bladder cancer. Journal of Biology, Agriculture and Healthcare. 2015; 5 (5): 218-225.

Karimianpour N, Mousavi-Shafaei P, Ziaee AA, Akbari MT, Pourmand G, Abedi A, et al. Mutations of ras gene family in specimens of bladder cancer. Urol J. 2008; 5: 237-42.

Jebar A, Hurst C, Tomlinson D. FGFR3 and ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene. 2005; 24: 5218-5225.

Birkhahn M, Mitra AP, Williams AJ, Lam G, et al. Predicting recurrence and progression of non-invasive papillary bladder cancer at initial presentation based on quantitative gene expression profiles. Eur. Urol. 2010; 57: 12-20.

Krishnaraj R, Ralf S, Ulf R, Rap P, Albert

W

Parag G, Manoj J, Rakesh K, et al. Impact of age and gender on the clinicopathological characteristics of bladder cancer. Indian J. Urol. 2009; 25 (2): 207-210.

Al-Kashwan TA, Houshmand M, Al-Janabi A, Melconian AK, Al-Abbasi D, Al-Musawi MN, Rostami M, Yasseen AA. Specific-mutational patterns of p53 gene in bladder transitional cell carcinoma among a group of Iraqi patients exposed to war environmental hazards. BMC. Res. Notes. 2012; 5: 466.

Al-Yaqubi KJ, AL-Faisal AHM, AL-Mudahafar AMJ, Tobal K. Assessment of multidrug resistance gene (MDR1) expression in Iraqi acute myeloid leukemia patients. International Journal of Advanced Research. 2014; 2 (6): 375-383.

Al-Amili WA, Ali NA, and AL-Faisal AHM. Evaluation of oncogene protein p190/bcr-abl in some Iraqi chronic myelogenous leukemia patients. Iraqi Journal of Biotechnology. 2014; 13 (2): 248-252.

AL-Faisal AHM, Gaaib JN, Al-Alwan N, and Ghanim M. Evaluation the diagnostic and prognostic value of cytokeratin expression in Iraqi breast cancer patients. International Journal of Current Research. 2014; 6: 6346-6351.

Gaaib JN, AL-Faisal AHM, Al-Alwan N. Evaluation the diagnostic and prognostic value of human mammoglobin (MGB1) gene expression in Iraqi breast cancer patients. International of Journal of Advanced Research. 2014; 2 (4): 663-669.

AL-Ramahi IJK, AlFaisal AHM, and Abdul-Hassan IA. Micronucleus frequency among Iraqi thyroid disorder patients. Comp. Clin. Path. 2012; 23 (3): 683-688.

Al-Faisal AHM, AL-Ramahi IJ, Abudl-Hassan IA, Hamdan AT, and Barusrux S. Detection of heterozygous c. 1708C> T and c. 1978C> G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. Comp. Clin. Pathol. 2012; 21: 1-7.

Al-Deresawi MSG, Al-Faisal AHM. The correlation between thyroid hormones, reproductive hormones, body mass index (BMI) and hirsute in Iraqi women with polycystic ovary syndrome (PCOS). J. of university of Anbar for pure science.2013; 7 (2): 1-7.

Al-Faisal AM, Al-Rubiay TS. Association of body mass index (BMI) and reproductive hormones with polycystic ovary syndrome in Iraqi patients. International Journal of Advanced Research. 2014; 2 (11): 788-791.

Rabbani F, Cordon-Cardo C. Mutation of cell cycle regulators and their impact on superficial bladder cancer. Urol. Clin. North. Am. 2000; 27: 83-102.

Lucie C, Lurkin CI, Madelon NM, Van der A, Bas WG, Ellen C, et al. FGFR3, H-ras, K-ras, N-ras and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS ONE. 2010; 5 (11): 1-13.

Platt FM, Hurst CD, Taylor CF, Gregory WM, Harnden P, et al. Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer. Clin Cancer Res. 2009; 15: 6008-6017.

Meteab SB. Detection of Genetic Alterations of FGFR3 Gene in Iraqi patients with bladder cancer. 2015; M.Sc. Thesis. Institute of Genetic Engineering and Biotechnology for Postgraduate Studies. University of Baghdad. Iraq.

American Cancer Society. Cancer Facts and Figures 2015. Atlanta. Ga.

Zeegers MP, Tan FE, Dorant E, and Van den Brandt PA. The impact of characteristics of cigarette smoking on urinary tract cancer risk: A meta-analysis of epidemiologic studies. Cancer. 2000; 89: 630-639.

Kune GA, Kune S, Vietta L, and Watson LF. Smoking and colorectal cancer risk: Data from the Melbourne colorectal cancer study and brief review of literature. Int J Cancer. 1992; 50: 369-72.

Slattery ML, Potter JD, Friedman GD, Ma KN, and Edwards S. Tobacco use and colon cancer. Int J Cancer. 1997; 70: 259-64.

Doll R, Peto R, Wheatley K, Gray R, and Sutherland I. Mortality in relation to smoking: 40 years

Carbone D. Smoking and cancer. Am J Med.1992; 93: 1A-13S-17S.

Spruck CH III, Rideout WM III, Olumi AF, Ohneseit PF, Yang AS, Tsai YC, et al. Distinct pattern of p53 mutations in bladder cancer: Relationship to tobacco usage. Cancer Res. 1993; 53: 1162-6.

Suzuki H, Takahashi T, Kuroishi T, Suyama M, Ariyoshi Y, Takahashi T, et al. P53 mutations in non-small lung cancer in Japan: Association between mutations and smoking. Cancer Res. 1992; 52: 734-6.

Garrett B, Dube S, Trosclair A, et al. Centers for disease control and prevention. M.M.W.R. Surveill Summ. 2011; 60: 109-113.

Hartge P, Harvey E, Linehan W, et al. Unexplained excess risk of bladder cancer in men. J. Natl. Cancer Inst. 1990; 82 (20): 1636-1640.

Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette. Chem. Res. Toxicol. 2001; 14 (7): 767-790.

Puente D, Hartge P, Greiser E, et al. A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women. Cancer Causes Control. 2006; 17 (1): 71-79.

Cogliano V, Baan R, Straif K, et al. Preventable exposures associated with human cancers. J. Natl. Cancer Inst. 2011; 103 (24): 1827-39.

Neal D, Freedman P, Debra T, et al. Association between smoking and risk of bladder cancer among men and women. OR. CO. 2011; 306 (7): 737-745.

Negri E, and Vecchia C. Epidemiology and prevention of bladder cancer. European Journal of Cancer Prevention. 2001; 10: 7-14.

Semenza J, Ziogas A, Largent J, et al. Gene environment interactions in renal cell carcinoma. Am. J. Epidemiol. 2001; 153: 851-859.

Zeegers M, Goldbohm R, Brandt P. A prospective study on active and enviromental tobacco smoking and bladder cancer risk. Cancer Causes and Control. 2002; 13: 83-90.

Pelucchi C, Vecchia C, Negri E, et al. Smoking and other risk factors for bladder cancer in women. Preventive Medicine. 2002; 35: 114-120.

Christmann M, Tomicic M, Roos W, Kaina B. Mechanisms of human DNA repair an update. Toxicology. 2003; 193: 3-34.

Mao Z, Bozzella M, Seluanov A, Gorbunova V. DNA repair by non-homologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle. 2008; 7: 2902-2906.

Ouerhani S, Rouissi K, Kourda N, et al. Combined analysis of smoking, TP53, and FGFR3 mutations in Tunisian patients with invasive and superficial high-grade bladder tumors. Cancer Invest. 2009; 27 (10): 998-1007.

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Published

2015-11-05

How to Cite

AlFaisal, A. H., & Nafeh, M. A. (2015). Detection of Five Novel Mutations in K-ras Gene for Iraqi Patients with Bladder Cancer. International Journal of Sciences: Basic and Applied Research (IJSBAR), 24(5), 76–86. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/4816

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