Comparative Study: PRP Enhanced Fat Graft Versus Fat Graft Alone in Treatment of Postacne Scars with Clinical and Histopathological Eyes

Authors

  • Omar Ahmed Azzam Faculty of Medicine, Cairo University
  • Maamoun Ismail
  • Laila Rashed
  • Ahmed Tarek Atta
  • Naglaa Sameh Zaki
  • Hamed M. Kadry
  • Pakinam Ibrahim Nabil Mostafa

Keywords:

Fat graft, PRP, Acne scars

Abstract

Fat grafting has a role in rejuvenation owing to its mesenchymal cell precursor content especially with growth factors added. Platelet Rich Plasma (PRP) is known for its high growth factor content. The objective of this study is to compare the effect of PRP when added to fat graft in acne scars. 28 patients were randomly divided into 2 groups. Group A was treated with fat grafting while group B was treated with PRP enhanced fat grafting. All patients received a single treatment session. Assessment was conducted by comparing digital photos and biopsies before and after 6 months of treatment. The results shows that acne scars improved with PRP enhanced fat graft (93%) more than fat graft (64%). The biopsy results also confirmed the significantly better improvement for PRP group (85.7%) than the fat graft group (58%) (p=0.042).

PRP has provided an enhancement of fat grafting in treatment of post acne scars. Icepick scars were better treated by fat grafting alone, while rolling and boxcars showed better results with the addition of PRP.

References

D. Fife.

E.P. Tierney.

G.J. Goodman.

O.A. Azzam, A.T. Atta, R.M. Sobhi, P.I.N. Mostafa.

N. Rongsaard and P. Rummaneethorn.

A. Mojallal, C. Lequeux, C. Shipkov, et al.

B. Cousin, V. Planat, G. Charriere l., et al.

A. Mojallal and J.L. Foyatier.

D.H. Kim, Y.J. Je and Y. Lee.

A.S. Wasterlain, H.J. Braun and J.L. Dragoo.

D. Dionyssiou, E. Demiri, P. Foroglou, et al.

S.B. Cho, S.J. Lee, S. cho, et al.

L. Formigli , S. Benvenuti , R. Mercatelli , et al.

J. Textor.

E. Anitua, M.M. Zalduendo, MH Alkhraisat and G.Oriv. Release kinetics of platelet-derived and plasma-derived growth factors from autologous plasma rich in growth factors. Annals of Anatomy,195: 461

H.B. Park, J.H. Yang and K.H. Chung.

C.E. Sommeling, A Heyneman, H. Hoeksema, et al.

X. Xie, S. Zhao, H. Wu, et al.

M.R. Kaufman, J.P. Bradley, B. Dickinson, et al.

S.O. Keyhan, S. Hemmat, A.A. Badri, et al.

R.J. Rohrich, E.S. Sorokin and S.A. Brown.

A.V. Padoin, J. Braga-Silva, P. Martins , et al.

A. Wilson, P.E. Butler and A.M. Seifalian.

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Published

2015-08-04

How to Cite

Azzam, O. A., Ismail, M., Rashed, L., Atta, A. T., Zaki, N. S., Kadry, H. M., & Mostafa, P. I. N. (2015). Comparative Study: PRP Enhanced Fat Graft Versus Fat Graft Alone in Treatment of Postacne Scars with Clinical and Histopathological Eyes. International Journal of Sciences: Basic and Applied Research (IJSBAR), 24(1), 165–178. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/4446

Issue

Vol. 24 No. 1 (2015)

Section

Articles

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