Transgenesis as a Tool to Reduce Parasite -Vector Interaction: a Review on the Progress for the Use of Genetically Manipulated Anopheles Mosquitoes to Control Malaria
Keywords:Transgenic mosquitoes, vector competence, Anopheles, Plasmodium, symbiotic bacteria
Malaria kills millions of people every year, imposing major economic and social burdens. Despite many efforts the classical control interventions which focus mainly on vector management and treatment of affected individuals with drugs. These interventions have proven inadequate to stop the transmission of Plasmodium parasites, subsequently the spread of malaria by Anopheles mosquitoes. The progressive numbers of insecticide-resistant insects and drug-resistant parasites have led to the search for a novel arsenal of strategies for inhibiting Plasmodium infection of mosquitoes. This work reviews current knowledge on genetic manipulation in mosquitoes that holds promise for development of transgenic mosquito refractory to malaria parasites transmission.
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