ATP-Induced Nuclear and Cytosolic Ca2+ Signal in Various Stages of Interphase HeLa/Fucci2 Cell
Keywords:
cell cycle, interphase HeLa/Fucci2 cell, intracellular calcium ion, dynamicsAbstract
Cell cycle progression involves the coordination of growth, DNA replication and division in proliferating cells. These intracellular activities are linked with calcium signaling in which calcium ion (Ca2+) act as a second messenger or as an agent for phosphorylation processes. Previous studies have examined the Ca2+ in the dividing cells; however, none of these gave the detailed explanation on Ca2+ dynamics in an interphase cell. This study addresses here the issue of whether the nuclear and cytosolic Ca2+ concentrations ([Ca2+]n and [Ca2+]c) changes are
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