Royal Jelly Pretreatment Can Either Protect or Aggravate Brain Damage Induced by Hypoxia-Ischemia in Mice, Depending on its Dose
Keywords:
Royal jelly, brain hypoxia, brain ischemia, sodium dinitrate, mice.Abstract
Royal jelly is a bee-derived product with potent antioxidative and many other biological properties. The present study was designed to examine the effect of Royal jelly (RJ) on brain damage induced by hypoxia-ischemia in mice. Mice were given RJ orally one dose / day (0-300 mg/kg body wt./ day for 13 consecutive days, survival time of mice were recorded following decapitation (Total brain ischemia model; model-1) and i. p. injection of NaNO2 to induce brain hypoxia (model-2).
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