Serum Cytokines Profiles and Some Salivary Parameters in Chronic Periodontitis Patients in Mosul - Iraq
Keywords:
Periodontitis, pocket depth, cytokines, and sIgA.Abstract
The aim of study is to measure serum IL-1 ?, IL-6, IL-8, IFN-? and TNF-? levels, and some of salivary parameters like sIgA, total protein and peroxidase specific activity in patients with chronic periodontitis in Mosul and compared them with control group. The study population consisted of 91 patients suffering from chronic periodontitis, aging between ?18-73 years old and 18 control samples collected from healthy individuals ranged between 23-35 years old. Blood and saliva samples were collected from patients and control groups to measure serum IL-1?, IL-6, IL-8, IFN-? and TNF-? ,and salivary sIgA , total protein levels and peroxidase specific activity . In the present study most of patients were showed localized chronic periodontitis, ranging from severe 57% to moderate infection 43%.Salivary sIgA level showed significant increase in chronic periodontitis comparing with control group.Patients group showed significance correlation between serum TNF-? with serum IL-1?, IL-6 and IFN-? levels. Also serum IL-1? level showed significant correlation with salivary sIgA and total protein levels. Furthermore negative correlations were detected between salivary sIgA and serum IL-8, as well asbetween salivary total protein and peroxides specific activity.
According to periodontal pocket depth, serum IL-1?, IFN-?, salivary sIgA levels and salivary peroxidase specific activity showed significance increase in patients with 7mm pocket depth. In the present study, most of patients showed localized chronic periodontitis. Salivary sIgA level showed significant increase in chronic periodontitis comparing with control group. Serum IL-1?, IFN-?, salivary sIgA levels and salivary peroxidase specific activitywere linked with 7mm periodontal pocket depth.
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