Anti-Arrhythmic Effect of Amiodarone Against Salbutamol and Aminophylline

Abstract

Tachycardia refers to an abnormally fast resting heart rate. The higher-than-normal heartbeat means there is an increase in demand for oxygen by the myocardium (heart muscle) - if this persists it can lead to myocardial infarction. There are many causes to tachycardia, and one of them is the using of ant- asthmatic drugs like salbutamol and aminophylline which are well defined to cause tachycardia. This study Used the amiodaron to overcome tachycardia that associated with use of salbutamol and aminophylline. A group of 18 New Zealand rabbits were subdivided into 3 groups; first group (G1) was control, second group (G2) was salbutamol group, and the third group (G3) was aminophylline group. G2 and G3 received salbutamol and aminophylline respectively for one day, and then administered salbutamol plus amiodaron and aminophylline plus amiodaron respectively at another day, all the drugs were administered intravenously at dose (1mg\kg). The parameters are heart rate, respiratory rate and arterial oxygen tension which were measured in each group and after 15,30,60,90,120 minutes of administration. The results shows that when salbutamol and aminophylline used alone they caused increasing in heart rate and there was a highly significant difference (P<0.01) than normal. While the mixing of amiodarone with them, the heart rate was near to normal and there was non significant difference (P>0.05).