Wound Healing, Antioxidants and Toxicological Properties of Root Extracts of Kigelia africana (Lam.) Benth

Authors

  • Hassan S. W. Department of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria
  • Mshelia P. Y.
  • Abubakar M. G.
  • Adamu Y. A.
  • Yakubu A. S.

Keywords:

Kigelia africana, wound healing, antioxidants, antibacterial activity, toxicity

Abstract

The root extracts of Kigelia africana were screened for antibacterial and wound healing properties, using hole-plate bioassay and excision wound model on rats, respectively. Catalase activity, glutathione level and lipid peroxidation were assayed in the granulated tissues and liver homogenates. Chemical compositions of the root were determined using standard methods. Complete wound healing was observed on day 16 in group administered with 120mg/ml and on the 19th day in groups administered 90 and 60mg/ml of the extract. Clinical features indicate redness, scab formation, exudations and some other typical changes. The control and antibiotic treated groups show more redness compared to third day. The hydrolytic and organic solvent fractions show significant (p< 0.05) inhibitory activities on wound

Author Biography

Hassan S. W., Department of Biochemistry, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria

Biochemistry, Associate Professor

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2015-01-01

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W., H. S., Y., M. P., G., A. M., A., A. Y., & S., Y. A. (2015). Wound Healing, Antioxidants and Toxicological Properties of Root Extracts of Kigelia africana (Lam.) Benth. International Journal of Sciences: Basic and Applied Research (IJSBAR), 19(1), 251–268. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/2137

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Vol. 19 No. 1 (2015)

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