Literature Review: Cranberry as Prophylaxis for Dapagliflozin-Induced Urinary Tract Infections
Keywords:
Sodium-glucose cotransporter-2, dapagliflozin, glucose absorption, Urinary tract infections, glucosuria, cranberryAbstract
Urinary tract infections [UTIs] are a common occurrence among type 2 diabetic patients using sodium-glucose cotransporter-2 [SGLT2] inhibitors to manage their diabetes. Dapagliflozin is among the most widely prescribed SGLT2i’s, and it achieves the desired effect by inhibiting the reabsorption of glucose in the kidney's proximal tubule, thereby increasing the excretion of glucose via the urinary tract. However, this mechanism of action of SGLT2i's leads to glucosuria, which increases the risk of UTIs. Since cranberries contain many beneficial medicinal compounds, including proanthocyanidins, this literature review study sought to establish the potential of using cranberries as a prophylaxis for dapagliflozin-induced UTI.
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