Literature Review: Cranberry as Prophylaxis for Dapagliflozin-Induced Urinary Tract Infections

Authors

  • Fahad AlSubaie Pharmacist, Saudi Arabia, King Abdulaziz Hospital of National Guard in AlAhsa
  • Hassan Salami Pharmacist, Saudi Arabia, King Abdulaziz Hospital of National Guard in AlAhsa
  • Ahmed Alsalman Pharmacist, Saudi Arabia, King Abdulaziz Hospital of National Guard in AlAhsa
  • Muath Alduhailan Pharmacist, Saudi Arabia, King Abdulaziz Hospital of National Guard in AlAhsa

Keywords:

Sodium-glucose cotransporter-2, dapagliflozin, glucose absorption, Urinary tract infections, glucosuria, cranberry

Abstract

Urinary tract infections [UTIs] are a common occurrence among type 2 diabetic patients using sodium-glucose cotransporter-2 [SGLT2] inhibitors to manage their diabetes. Dapagliflozin is among the most widely prescribed SGLT2i’s, and it achieves the desired effect by inhibiting the reabsorption of glucose in the kidney's proximal tubule, thereby increasing the excretion of glucose via the urinary tract. However, this mechanism of action of SGLT2i's leads to glucosuria, which increases the risk of UTIs. Since cranberries contain many beneficial medicinal compounds, including proanthocyanidins, this literature review study sought to establish the potential of using cranberries as a prophylaxis for dapagliflozin-induced UTI.    

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Published

2024-06-17

How to Cite

Fahad AlSubaie, Hassan Salami, Ahmed Alsalman, & Muath Alduhailan. (2024). Literature Review: Cranberry as Prophylaxis for Dapagliflozin-Induced Urinary Tract Infections. International Journal of Sciences: Basic and Applied Research (IJSBAR), 73(1), 124–129. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/16723

Issue

Vol. 73 No. 1 (2024)

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Articles

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