The kinetics of IgG Antibodies in Critically Ill Patients

  • mona Jabrane Departement of microbiolgy, Mohammed VIth University Hospital of Marrakech, Marrakech, Morocco.
  • Asmaa Lamrani Hanchi Departement of microbiolgy, Mohammed VIth University Hospital of Marrakech, Marrakech, Morocco.
  • Nabila Soraa Departement of microbiolgy, Mohammed VIth University Hospital of Marrakech, Marrakech, Morocco.
  • Rabab Bellaka Department of Anesthesia and Intensive Care Medicine, Mohammed VIth University Hospital of Marrakech, Marrakech, Morocco.
  • Abdelhamid Hachimi Department of Anesthesia and Intensive Care Medicine, Mohammed VIth University Hospital of Marrakech, Marrakech, Morocco.
Keywords: COVID-19, antibody, illness severity, immunoglobulin G, SARS-CoV-2

Abstract

the kinetics of SARS-CoV-2 antibodies response and factors predicting igG levels are still limited. We report a prospective analytical study of patients admitted for SARS-cov-2 in the medical intensive care unit of the Mohammed VIth University Hospital of Marrakech for three months.We measured the level of igG antibodies to SARS-Cov-2 on plasma blood samples from all patients collected on admission  and then every seven days respectively until discharge or death. The kinetics of antibodies with disease progress were analyzed. The mean igG levels increased between ICU admission till day 21, then they dropped on day 28. Critical patients had higher igG levels than severe ones with no statistically significant difference. Between day one and day 14, males had higher igG levels than females; however, females had higher levels on days 21 and 28 with a statistically significant difference on day 28. On the chest CT scan, patients with ground-glass opacities and/or crazy paving distribution of 75% or more had higher igg levels with a statistically significant difference on day 7. In terms of mortality, deceased patients had higher igG levels with no statistically significant difference than survivors. Our results may suggest the incrimination of SARS-cov-2 igg antibody high level as a prognostic factor for disease severity.

References

Coronavirus Disease (COVID-19) Situation Reports n.d. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (accessed November 23, 2021).

Maladie à coronavirus (COVID-19) | UNICEF n.d. https://www.unicef.org/morocco/recits/maladie-%C3%A0-coronavirus-covid-19 (accessed November 23, 2021).

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med 2020;382:929–36. https://doi.org/10.1056/NEJMoa2001191.

Tyrrell DAJ, Myint SH. Coronaviruses. In: Baron S, editor. Medical Microbiology. 4th ed., Galveston (TX): University of Texas Medical Branch at Galveston; 1996.

van Dorp L, Acman M, Richard D, Shaw LP, Ford CE, Ormond L, et al. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. Infection, Genetics and Evolution 2020;83:104351. https://doi.org/10.1016/j.meegid.2020.104351.

Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, et al. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clinical Infectious Diseases 2020;71:778–85. https://doi.org/10.1093/cid/ciaa310.

Long Q-X, Liu B-Z, Deng H-J, Wu G-C, Deng K, Chen Y-K, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med 2020;26:845–8. https://doi.org/10.1038/s41591-020-0897-1.

Li G, Chen X, Xu A. Profile of Specific Antibodies to the SARS-Associated Coronavirus. New England Journal of Medicine 2003;349:508–9. https://doi.org/10.1056/NEJM200307313490520.

Covid-19 : bientôt des tests pour vérifier l’efficacité de votre vaccin ? n.d. https://www.futura-sciences.com/sante/actualites/coronavirus-covid-19-bientot-tests-verifier-efficacite-votre-vaccin-86884/ (accessed November 23, 2021).

Xiao AT, Gao C, Zhang S. Profile of specific antibodies to SARS-CoV-2: The first report. Journal of Infection 2020;81:147–78. https://doi.org/10.1016/j.jinf.2020.03.012.

Sun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, et al. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerging Microbes & Infections 2020;9:940–8. https://doi.org/10.1080/22221751.2020.1762515.

Wang X, Guo X, Xin Q, Pan Y, Hu Y, Li J, et al. Neutralizing Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in Coronavirus Disease 2019 Inpatients and Convalescent Patients. Clinical Infectious Diseases 2020;71:2688–94. https://doi.org/10.1093/cid/ciaa721.

download.pdf n.d.

Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, et al. Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019. Clin Infect Dis 2020;71:2027–34. https://doi.org/10.1093/cid/ciaa344.

Hotez PJ, Corry DB, Bottazzi ME. COVID-19 vaccine design: the Janus face of immune enhancement. Nat Rev Immunol 2020;20:347–8. https://doi.org/10.1038/s41577-020-0323-4.

Perera RA, Mok CK, Tsang OT, Lv H, Ko RL, Wu NC, et al. Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020. Eurosurveillance 2020;25:2000421. https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000421.

Wolfe J, Safdar B, Madsen TE, Sethuraman KN, Becker B, Greenberg MR, et al. sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-CoV-2. Clinical Therapeutics 2021;43:557-571.e1. https://doi.org/10.1016/j.clinthera.2021.01.015.

Majdoub Fehri S, Abdelmouleh K, Ghorbel H, Khrouf M, Fezai N, Kwas H. Infection COVID-19 selon le sexe : quelle relation ? Revue des Maladies Respiratoires Actualités 2021;13:113–4. https://doi.org/10.1016/j.rmra.2020.11.235.

Ko J-H, Joo E-J, Park S-J, Baek JY, Kim WD, Jee J, et al. Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients. Journal of Clinical Medicine 2020;9. https://doi.org/10.3390/jcm9072268.

Zhang X, Lu S, Li H, Wang Y, Lu Z, Liu Z, et al. Viral and Antibody Kinetics of COVID-19 Patients with Different Disease Severities in Acute and Convalescent Phases: A 6-Month Follow-Up Study. Virol Sin 2020;35:820–9. https://doi.org/10.1007/s12250-020-00329-9.

Bai Z, Li Q, Chen Q, Niu C, Wei Y, Huang H, et al. Clinical significance of serum IgM and IgG levels in COVID-19 patients in Hubei Province, China. Journal of Intensive Medicine 2021:S2667100X21000311. https://doi.org/10.1016/j.jointm.2021.09.001.

To KK-W, Tsang OT-Y, Leung W-S, Tam AR, Wu T-C, Lung DC, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. The Lancet Infectious Diseases 2020;20:565–74. https://doi.org/10.1016/S1473-3099(20)30196-1.

Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol 2020;20:269–70. https://doi.org/10.1038/s41577-020-0308-3.

Iwasaki A, Yang Y. The potential danger of suboptimal antibody responses in COVID-19. Nat Rev Immunol 2020;20:339–41. https://doi.org/10.1038/s41577-020-0321-6.

Is COVID-19 receiving ADE from other coronaviruses? | Elsevier Enhanced Reader n.d. https://doi.org/10.1016/j.micinf.2020.02.006.

Yoshikawa T, Hill T, Li K, Peters CJ, Tseng C-TK. Severe Acute Respiratory Syndrome (SARS) Coronavirus-Induced Lung Epithelial Cytokines Exacerbate SARS Pathogenesis by Modulating Intrinsic Functions of Monocyte-Derived Macrophages and Dendritic Cells. Journal of Virology 2009;83:3039–48. https://doi.org/10.1128/JVI.01792-08.

Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK, et al. Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe 2016;19:181–93. https://doi.org/10.1016/j.chom.2016.01.007.

Published
2022-06-09
How to Cite
Jabrane, mona, Asmaa Lamrani Hanchi, Nabila Soraa, Rabab Bellaka, & Abdelhamid Hachimi. (2022). The kinetics of IgG Antibodies in Critically Ill Patients. International Journal of Sciences: Basic and Applied Research (IJSBAR), 62(2), 347-356. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14082
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Articles