The Relationship Between the Body Mass Index and the Controlled Ovarian Stimulation Outcomes
Keywords:
BMI, IVF, controlled ovarian stimulationAbstract
When assessing the impact of body mass index (BMI) values on controlled ovarian outcomes, high BMI tips the balance regarding negative impact. Although not all studies agree, it seems that both intermediary and definite endpoints are offset, and the effect is progressively more significant with increasing BMI. In addition, evidence suggests that oocyte quality and endometrial receptivity are lower in overweight and obese patients. Perfecting how increased weight is quantified and unifying definitions of parameters assessed emerge as ways in which a more concise view of the impact of BMI on in vitro fertilization (IVF) procedures could be achieved. The unifying viewpoint is that weight interventions could improve natural and assisted conception results and assure a safer pregnancy for both mother and child. Still, how weight loss could be achieved, especially in these women to whom time pressure is added, remain to be refined.
References
Catalano PM and Shankar K, "Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child.," BMJ, vol. 356, no. j1, 2017.
Pandey S, Maheshwari A and Bhattacharya S, "Should access to fertility treatment be determined by female body mass index?," Hum Reprod, vol. 25, no. 4, pp. 815-20, 2010.
Sermondade N, Huberlant S, Bourhis-Lefebvre V, Arbo E, Gallot V, Colombani M and Fréour T, "Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis," Hum Reprod Update, vol. 25, no. 4, pp. 439-451, 2019.
Broughton DE and Moley KH, "Obesity and female infertility: potential mediators of obesity's impact," Fertil Steril, vol. 107, no. 4, pp. 840-847, 2017.
Wise LA, Rothman KJ, Mikkelsen EM, Sørensen HT, Riis A and Hatch EE, "An internet-based prospective study of body size and time-to-pregnancy," Hum Reprod, vol. 25, no. 1, pp. 253-64, 2010.
Friedler S, Cohen O, Liberty G, Saar-Ryss B, Meltzer S and Lazer T, "Should high BMI be a reason for IVF treatment denial?," Gynecol Endocrinol, vol. 33, no. 11, pp. 853-856, 2017.
Provost MP, Acharya KS, Acharya CR, Yeh JS, Steward RG, Eaton JL, Goldfarb JM and Muasher SJ, "Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008-2010 Society for Assisted Reproductive Technology registry," Fertil Steril, vol. 105, no. 3, pp. 663-669, 2016.
Maheshwari A, Stofberg L and Bhattacharya S, "Effect of overweight and obesity on assisted reproductive technology--a systematic review," Hum Reprod Update, vol. 13, no. 5, pp. 433-44, 2007.
Setti AS, Braga DP, Figueira Rde C, Vingris L, Iaconelli A and Borges E Jr, "Body mass index is negatively correlated with the response to controlled ovarian stimulation but does not influence oocyte morphology in ICSI cycles," Eur J Obstet Gynecol Reprod Biol, vol. 163, no. 2, pp. 175-9, 2012.
Brunet C, Aouinti S, Huguet F, Macioce V, Ranisavljevic N, Gala A, Avignon A, Mura T and Sultan A , "Impact of Women Obesity and Obesity Severity on Live Birth Rate after In Vitro Fertilization," J Clin Med, vol. 9, no. 8, p. 2414, 2020.
Martinuzzi K, Ryan S, Luna M and Copperman AB, "Elevated body mass index (BMI) does not adversely affect in vitro fertilization outcome in young women," J Assist Reprod Genet, vol. 25, no. 5, pp. 169-75, 2008.
Bellver J, Ayllón Y, Ferrando M, Melo M, Goyri E, Pellicer A, Remohí J and Meseguer M, "Female obesity impairs in vitro fertilization outcome without affecting embryo quality," Fertil Steril, vol. 93, no. 2, pp. 447-54, 2010.
Bellver J, Pellicer A, García-Velasco JA, Ballesteros A, Remohí J and Meseguer M, "Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors," Fertil Steril, vol. 100, no. 4, pp. 1050-8, 2013.
Bellver J, Melo MA, Bosch E, Serra V, Remohí J and Pellicer A, "Obesity and poor reproductive outcome: the potential role of the endometrium," Fertil Steril, vol. 88, no. 2, pp. 446-51, 2007.
Bellver J, Martínez-Conejero JA, Labarta E, Alamá P, Melo MA, Remohí J, Pellicer A and Horcajadas JA, "Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome," Fertil Steril, vol. 2341, pp. 2335-41, 2011.
Coyne K, Whigham LD, O'Leary K, Yaklic JK, Maxwell RA and Lindheim SR, "Gestational carrier BMI and reproductive, fetal and neonatal outcomes: are the risks the same with increasing obesity?," Int J Obes (Lond), vol. 40, no. 1, pp. 171-5, 2016.
Comstock IA, Kim S, Behr B and Lathi RB, "Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization," J Assist Reprod Genet, vol. 32, no. 9, pp. 1299-304, 2015.
Valckx SD, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, Bols PE and Leroy JL, "BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality.," Hum Reprod, vol. 27, no. 12, pp. 3531-9, 2012.
Jungheim ES, Schon SB, Schulte MB, DeUgarte DA, Fowler SA and Tuuli MG, "IVF outcomes in obese donor oocyte recipients: a systematic review and meta-analysis," Hum Reprod, vol. 28, no. 10, pp. 2720-7, 2013.
Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto V and Leach R, "Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates," Hum Reprod, vol. 26, no. 1, pp. 245-52, 2011.
Vural F, Vural B and Çakıroğlu Y, "The Role of Overweight and Obesity in In Vitro Fertilization Outcomes of Poor Ovarian Responders," Biomed Res Int, vol. 2015, p. 781543, 2015.
Rabinson J, Meltcer S, Zohav E, Gemer O, Anteby EY and Orvieto R, "GnRH agonist versus GnRH antagonist in ovarian stimulation: the influence of body mass index on in vitro fertilization outcome," Fertil Steril, vol. 89, no. 2, pp. 472-4, 2008.
Li Y, Duan Y, Yuan X, Cai B, Xu Y and Yuan Y, "A Novel Nomogram for Individualized Gonadotropin Starting Dose in GnRH Antagonist Protocol," Front Endocrinol (Lausanne), vol. 12, p. 688654, 2021.
Kalliala I, Markozannes G, Gunter MJ , Paraskevaidis E, Gabra H, Mitra A, Terzidou V, Bennett P , Martin-Hirsch PT, Tsilidis KK and Kyrgiou M, "Obesity and gynaecological and obstetric conditions : umbrella review of the literature," BMJ, vol. 359, no. 4511, 2017.
Metwally M, Ong KJ, Ledger WL and Li TC, "Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence.," Fertil Steril, vol. 90, no. 3, pp. 714-26, 2008.
Goldman KN, Hodes-Wertz B, McCulloh DH, Flom JD and Grifo JA, "Association of body mass index with embryonic aneuploidy," Fertil Steril, vol. 103, no. 3, pp. 744-8, 2015.
Boots CE, Bernardi LA and Stephenson MD, "Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss," Fertil Steril, vol. 102, no. 2, pp. 455-9, 2014.
Bellver J, Rossal LP, Bosch E, Zúñiga A, Corona JT, Meléndez F, Gómez E, Simón C, Remohí J and Pellicer A, "Obesity and the risk of spontaneous abortion after oocyte donation," Fertil Steril, vol. 79, no. 5, pp. 1136-40, 2003.
Christofolini J, Maria Christofolini D, Zaia V, Bianco B and Barbosa CP, "Body fat distribution influences ART outcomes," Gynecol Endocrinol, vol. 36, no. 1, pp. 40-43, 2020.
Oliva M, Nazem TG, Lee JA and Copperman AB., "Evaluating in vitro fertilization outcomes of patients with low body mass index following frozen-thawed embryo transfer," Int J Gynaecol Obstet, vol. 155, no. 1, pp. 132-137, 2021.
Rothberg A, Lanham M, Randolph J, Fowler C, Miller N and Smith Y, "Feasibility of a brief, intensive weight loss intervention to improve reproductive outcomes in obese, subfertile women: a pilot study," Fertil Steril, vol. 106, no. 5, pp. 1212-1220, 2016.
Best D, Avenell A and Bhattacharya S, "How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese? A systematic review and meta-analysis of the evidence," Hum Reprod Update, vol. 23, no. 6, pp. 681-705, 2017.
Sim KA, Partridge SR and Sainsbury A, "Does weight loss in overweight or obese women improve fertility treatment outcomes? A systematic review," Obes Rev, vol. 15, no. 10, p. 2014, 839-50.
Einarsson S, Bergh C, Friberg B, Pinborg A, Klajnbard A, Karlström PO, Kluge L, Larsson I, Loft A, Mikkelsen-Englund AL, Stenlöf K, Wistrand A and Thurin-Kjellberg A, "Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial," Hum Reprod, vol. 32, no. 8, pp. 1621-1630, 2017.
Kluge L, Bergh C, Einarsson S, Pinborg A, Mikkelsen Englund AL and Thurin-Kjellberg A, "Cumulative live birth rates after weight reduction in obese women scheduled for IVF: follow-up of a randomized controlled trial," Hum Reprod Open, vol. 2019, no. 4, p. hoz030, 2019.
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