The Association Between Saturated Fatty Acids (SFAs) Level in Dietary and Blood During Pregnancy and SFAs Level in Breast Milk of Postpartum Mothers
Keywords:
Saturated Fatty Acids, Pregnancy, Blood, Dietary, Breast MilkAbstract
Saturated fatty acids (SFAs) in breast milk are essential for infant’s metabolism as a major metabolic fuel and a low level of SFAs in breast milk might be detrimental for infants’ growth. SFAs in breast milk is determined by maternal SFAs intake and blood levels. Several studies on maternal SFAs have been conducted on breastfeeding mothers but rarely conducted in pregnant women, meanwhile there is an increased SFAs in intake and blood levels in pregnant women on their third trimester due to fat mobilization. This study aims to analyze the relationship between SFAs level in dietary and blood during pregnancy to their levels in breast milk. This research was a longitudinal study and some research data were derived from the BSEA and IPB main research in May-December 2018 at two Bogor City Health Centers, Indonesia. Ninety-eight pregnant women were selected through consecutive sampling method. The data analysis was using Spearman test and Multiple logistic regression. There is no significant relation between SFAs level in dietary with SFAs level in blood. However, dietary intake of lauric acid and total SFAs were significantly associated with lauric acid and total SFAs in breast milk (p<0.05), but not significantly correlated with other types of SFAs (p>0.05). The level of capric, myristate, palmitic, behenic, and lignoceric acids in blood is associated with corresponding SFAs (p<0.05). As a conclusion, SFAs intake in third semester of pregnancy is allowed since increased SFAs in breast milk is important for infants’ early growth.
References
Andreas N, Kampmann B, Mehring L. "Human breast milk: A review on its composition and bioactivity". Earl Hum Dev. vol. 91, no. 11, pp. 629-635, 2015.
Calder PC. "Functional roles of fatty acids and their effects on human health". J Parenter Enteral Nutr. vol. 20, no. 10, pp. 1-15, 2015.
Yustiyani. "Asupan Dan Status Asam Lemak Tak Jenuh Ganda Pada Ibu Hamil Kaitannya Dengan Status Gizi Bayi Baru Lahir dan ASI Di Kota Bogor". M.Gz. thesis. IPB University, Indonesia, 2018.
Syahadah, Muti'ah Mustaqimatusy. "Asupan Asam Lemak Ibu saat Hamil dan Menyusui serta Hubungannya dengan Kandungan Asam Lemak ASI dan Lingkar Kepala Bayi". M.Gz. thesis. IPB University, Indonesia, 2018.
Innis SM. "Palmitic Acid in Early Human Development". Crit Rev Food Sci Nutr. vol. 56, no. 12. pp. 1952-1959, 2016.
Koletzko B, Rodriguez-Palmero M. "Polyunsaturated fatty acids in human milk and their role in early infant development". J Mammary Gland Biol Neoplasia. vol. 4, no. 3, pp. 269-284, 1994.
Francois C, Connor S, Wander R, Connor E. "Acute effects of dietary fatty acids on the fatty acids of human milk". Am J Clin Nutr. vol. 67, no. 2, pp. 301–308, 1998.
Geraghty A, Alberdi G, O'Sullivan E, O'Brien E, Crosbie, Twomey P, McAuliffe F. "Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study". PLoS One. vol. 11, no. 8. pp. e0161206, 2016.
Siziba L, Chimhashu T, Siro S, Ngounda J, Jacobs A, Malan L, Baumgartner J. "Breast milk and erythrocyte fatty acid composition of lactating women residing in a peri‐urban South African township". Prostaglandins, Leukot Essent Fatty Acids. vol. 156, pp. 102027, 2020.
Wardana, Ruliansyah K , Nurmasari W dan Adriyan P. "Hubungan Asupan Zat Gizi Makro dan Status Gizi Ibu Menyusui dengan Kandungan Zat Gizi Makro pada Air Susu Ibu (ASI) Di Kelurahan Bandarharjo Semarang". Journal of Nutrition College. vol. 7, no. 3, pp. 107-113, 2018.
Herrera E. "Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development a review". Placenta. vol. Suppl A, pp. S9-19, 2002.
Kawabata T, Kagawa Y, Kimura F, Miyazawa T, Saito S, Arima T, Nakai K, Yaegashi, N. "Polyunsaturated fatty acid levels in maternal erythrocytes of Japanese women during pregnancy and after childbirth". Nutrients. vol. 9, No. 3. pp. 245, 2015.
Folch J, Lees M, Sloane Stanley. "A simple method for the isolation and purification of total lipides from animal tissues". The Journal of Biological Chemistry. vol. 26, no. 1, pp. 497–509, 1957.
Sulaeman A, Hardinsyah, Setiawan B, Mulyani RI. "Kandungan Asam Lemak Pangan Indonesia". Bogor: Departemen Gizi Masyarakat FEMA IPB, PERGIZI PANGAN Indonesia, Global Alliance Improved Nutrition, dan Unilever Research and Development Center, 2015, pp. 45-63.
Food Standard Australia and New Zealand. "AUSNUT 2011-13: Food Nutrient". Internet: https://www.foodstandards.gov.au/science/monitoringnutrients/ausnut/Pages/about.aspx, August 2013 [Nov. 11, 2021]
Ministry of Education, Culture, Sports, Science and Technology-Japan. "Standar Tables of Food Compisition in Japan (Seventh Revised Version)". Internet: https://www.mext.go.jp/en/policy/science_technology/policy/title01/detail01/1374030.html, June 2015 [Nov.11, 2021]
Bachour P, Yafawi R, Jaber F, Choueiri E dan Abdel-Razzak Z. “Effects Smoking, Mother’s Age, Body Mass Index, and Parity Number on Lipid, Protein, and Secretory Immunoglobulin A Concentrations of Human Milk”. Breastfeeding Medicine. vol. 7, no. 3, pp. 179–188, 2012.
Stråvik M, Jonsson K, Hartvigsson O, Sandin A, Wold A, Sandberg A, Barman M. “Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden”. Nutrients. vol. 11, no. 7, pp. 1680, 2019.
Scifres C, Catov J, Simhan H. “The impact of maternal obesity and gestational weight gain on early and mid-pregnancy lipid profiles”. Obesity. vol. 22, no. 3, pp. 932–938, 2014.
Shrestha R, Hui SP, Imai H, Hashimoto S, Uemura N, Takeda S, Fuda H, Suzuki A, Yamaguchi S, Hirano K, Chiba H. “Plasma capric acid concentrations in healthy subjects determined by high-performance liquid chromatography”. Ann Clin Biochem. vol. 52, no. 5, pp. 588-596, 2015.
Donabedian R and Karmen A. “Fatty Acid Transport and Incorporation into Human Erythrocytes In Vitro”. J Clin Invest. vol. 46, no. 6, pp. 1017-1027, 1967.
Kim H, Sujeong K, Byung-Moon J, Hyunju Yi, Ji A. Jung, dan Namsoo. Breast milk fatty acid composition and fatty acid intake of lactating mothers in South. British Journal of Nutrition. vol. 117, no.4, pp. 556-561, 2017.
Scopesi F, Ciangherotti S, Lantieri P, Risso D, Bertini I, Campone F, Serra G. 2001. "Maternal dietary PUFAs intake and human milk content relationships during the first month of lactation". Clinical Nutrition. vol. 20, no. 5, pp. 393–397, 2001.
Johny A, Baskaran S, Charles A, Amalaradjou M, Darre M, Khan MI, Hoagland TA, Schreiber DT, Donoghue AM, Donoghue DJ. "Prophylactic supplementation of caprylic acid in feed reduces Salmonella enteritidis colonization in commercial broiler chicks". J Food Prot. vol. 72, no. 1, pp. 722–727, 2009.
Muelbert, M., Galante, L., Alexander, T. "Odor-active volatile compounds in preterm breastmilk". Pediatr Res. vol. xxx, 2021.
Spear M, Hamosh M, Bitman J, Spear M dan Wood L. "Milk and blood fatty acid composition during two lactations in the same woman". Am J Clin Nutr. vol. 1, no. 56, pp. 65-70, 1992.
NCBI. "PubChem Compound Summary for CID 3893, Lauric acid" Internet: https://pubchem.ncbi.nlm.nih.gov/compound/Lauric-acid#section=Information-Sources], 2021 [Nov.11, 2021]
Donabedian R and Karmen A. 1967. "Fatty Acid Transport and Incorporation into Human Erythrocytes In Vitro". J Clin Invest. vol. 46, no. 6, pp. 1017-1027, 1967.
Hornung B, Amtmann E, Sauer G. "Lauric acid inhibits the maturation of vesicular stomatitis virus". J Gen Virol. vol. 75 pp. 353–361, 1994.
Batovska D, Todorova I, Tsvetkova I, Najdenski H. "Antibacterial study of the medium chain fatty acids and their 1-monoglycerides: individual effects and synergistic relationships". Pol J Microbiol. vol. 58, pp. 43–47, 2009.
Reiner DS, Wang CS, Gillin FD. "Human milk kills Giardia lamblia by generating toxic lipolytic products". J Infect Dis. vol. 154, pp. 825–832, 1986.
Nasser R, Stephen A, Goh Y, Clandinin M. "The effect of a controlled manipulation of maternal dietary fat intake on medium and long chain fatty acids in human breast milk in Saskatoon, Canada". Int Breastfeed J. vol. 5, no. 1, pp. 3, 2010.
Mohammad MA, Sunehag AL, Haymond MW. "De novo synthesis of milk triglycerides in humans". Am J Physiol Endocrinol Metab. vol. 306. no. 7. pp. E838-E847, 2014.
Dabadie H, Peuchant E, Bernard M, LeRuyet P, Mendy F. "Moderate intake of myristic acid in sn-2 position has beneficial lipidic effects and enhances DHA of cholesteryl esters in an interventional study". J Nutr Biochem. vol. 16, pp. 375–382, 2005.
Ramírez M, Amate L, Gil A. "Absorption and distribution of dietary fatty acids from different sources" Early Hum Dev. vol. 65 (Suppl), pp. S95-S101, 2001.
Guyton G dan Hall J. Textbook of Medical Physiology 11th Edition. Philadelphia (US): Elsevier Saunders, 2006.
Barber M, Clegg R, Travers M, Vernon R. "Lipid metabolism in the lactating mammary gland". Biochim Biophys Acta. vol. 1347, no. 2-3, pp. 101-126, 1997.
Freitas F, Macedo M, Lessa A, Pinto N, Teixeira R. "Relationship between the Diet Quality Index in Nursing Mothers and The Fatty Acid Profile of Mature Breast Milk". Rev Paul Pediatr. vol. 39. no. e2019089, 2019.
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. "Hyperlipidemic effects of dietary saturated fats mediated through PGC-1 beta coactivation of SREBP". Cell. vol. 120, pp. 261–273, 2005.
Geraghty A, Alberdi G, O'Sullivan E, O'Brien E, Crosbie, Twomey P, McAuliffe F. “Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study”. PLoS One. vol. 11, no. 8, pp. e0161206, 2016.
Luoto R, Kinnunen T, Aittasalo M, Kolu P, Raitanen J. “Primary prevention of gestational diabetes mellitus and large-for-gestational-age newborns by lifestyle counseling: a cluster-randomized controlled Trial”. PLoS Medicine. vol. 8, no. 5, pp. e1001036, 2011.
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