Synthesis of 5-chloro-thiosulfadiazine Compounds Using Two-Phase Systems of Organic Solvents
Keywords:
Sulfadiazine, Thiophene, Na2CO3, NaOAc, H2OAbstract
We report a direct and simple protocol for the synthesis of 5-chloro-thiosulfadiazine compounds. This reaction has been achieved using two-phase systems of organic solvents (NaOAc/ H2O and Na2CO3/ H2O. The use of NaOAc or Na2CO3 for the preparation of chloro compounds provided all the advantages of cost, safety, and environmental concerns; thus, this method will give broad utility to the organic/medicinal chemist that is pursuing the synthesis of sulfonamides derivatives.
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