Synthesis of 5-chloro-thiosulfadiazine Compounds Using Two-Phase Systems of Organic Solvents

  • Sarah M. Maashi Department of Chemistry & Biochemistry, University of the Sciences in Philadelphia, Philadelphia, PA, 19104, United States,Department of Chemistry, Jazan University, Jazan, 82817, Saudi Arabia.
  • James R. McKee Department of Chemistry & Biochemistry, University of the Sciences in Philadelphia, Philadelphia, PA, 19104, United States.
Keywords: Sulfadiazine, Thiophene, Na2CO3, NaOAc, H2O

Abstract

We report a direct and simple protocol for the synthesis of 5-chloro-thiosulfadiazine compounds. This reaction has been achieved using two-phase systems of organic solvents (NaOAc/ H2O and Na2CO3/ H2O. The use of NaOAc or Na2CO3 for the preparation of chloro compounds provided all the advantages of cost, safety, and environmental concerns; thus, this method will give broad utility to the organic/medicinal chemist that is pursuing the synthesis of sulfonamides derivatives.

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Published
2021-11-20
Section
Articles