The Frequency of Dyslipidemia in Young Overweight and Obese Students (Age 10-16 Years) in Schools of Swat, Pakistan
AbstractObesity is a multifaceted disease caused by hormonal imbalance. There is a significant increase in the prevalence of childhood obesity across the globe. The study was conducted to estimate the frequency of Pediatric dyslipidemia. The Prevalence of obesity was determined by serum lipid concentrations of students in Private Schools of Swat. The cross-sectional analytical study enrolled 1374 Students, both boys (870) and girls (504). Detailed history of the students were recorded through a survey, which included student’s sociodemographic and clinical variables. BMI of students were calculated by the formula BMI=weight/height (kg/m2). The analysis of the data was done through SPSS Version 22. The students enrolled in this study were grouped on gender basis i.e, male (68) and female (31). The Prevalance of dyslipidemia was measured to be 42.4%. Significant association was found between the rate of dyslipidemia and BMI (59.5% in obese and 40.5% in overweight). No significant gender differences were found in serum lipid levels. The rate of dyslipidemia was measured to be a slightly increased in boys as compared to girls but not statistically significant.
. J. Baird, D. Fisher, P. Lucas, J. Kleijnen, H. Roberts, and C. Law, "Being big or growing fast: systematic review of size and growth in infancy and later obesity," Bmj, vol. 331, p. 929, 2005.
. D. C. Goff Jr, A. G. Bertoni, H. Kramer, D. Bonds, R. S. Blumenthal, M. Y. Tsai, et al., "Dyslipidemia prevalence, treatment, and control in the multi-ethnic study of atherosclerosis (MESA) gender, ethnicity, and coronary artery calcium," Circulation, vol. 113, pp. 647-656, 2006.
. U. Iqbal, B. J. Perumpail, D. Akhtar, D. Kim, and A. Ahmed, "The epidemiology, risk profiling and diagnostic challenges of nonalcoholic fatty liver disease," Medicines, vol. 6, p. 41, 2019.
. A. Misra, K. Luthra, and N. Vikram, "Dyslipidemia in Asian Indians: determinants and significance," Japi, vol. 52, pp. 137-142, 2004.
. K. K. Ong, "Early determinants of obesity," Adipose Tissue Development, vol. 19, pp. 53-61, 2010.
. M. Deurenberg-Yap, S. Chew, V. Lin, B. Tan, W. Van Staveren, and P. Deurenberg, "Relationships between indices of obesity and its co-morbidities in multi-ethnic Singapore," International Journal of Obesity, vol. 25, pp. 1554-1562, 2001.
. K. M. Flegal, J. A. Shepherd, A. C. Looker, B. I. Graubard, L. G. Borrud, C. L. Ogden, et al., "Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults," The American journal of clinical nutrition, vol. 89, pp. 500-508, 2009.
. Y. Chen, Y. Zhang, and L. Wang, "Low diagnostic accuracy of body mass index-based and waist circumference-based references of childhood overweight and obesity in identifying overfat among chinese children and adolescents," BioMed research international, vol. 2018, 2018.
. W. P. T. James, R. Jackson-Leach, C. N. Mhurchu, E. Kalamara, M. Shayeghi, N. J. Rigby, et al., "Overweight and obesity (high body mass index)," Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors, vol. 1, pp. 497-596, 2004.
. M. Ashwell and S. D. Hsieh, "Six reasons why the waist-to-height ratio is a rapid and effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity," International journal of food sciences and nutrition, vol. 56, pp. 303-307, 2005.
. A. Y. Shih, A. Arkhipov, P. L. Freddolino, S. G. Sligar, and K. Schulten, "Assembly of lipids and proteins into lipoprotein particles," ed: ACS Publications, 2007.
. J. D. Morrisett, R. L. Jackson, and A. M. Gotto Jr, "Lipoproteins: structure and function," Annual review of biochemistry, vol. 44, pp. 183-207, 1975.
. H. N. Ginsberg, "Lipoprotein physiology," Endocrinology and Metabolism Clinics, vol. 27, pp. 503-519, 1998.
. S. Eisenberg, D. W. Bilheimer, and R. I. Levy, "The metabolism of very low density lipoprotein proteins: II. Studies on the transfer of apoproteins between plasma lipoproteins," Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, vol. 280, pp. 94-104, 1972.
. M. Kumar, R. Nagpal, R. Kumar, R. Hemalatha, V. Verma, A. Kumar, et al., "Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases," Experimental diabetes research, vol. 2012, 2012.
. E. Ros, "Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk," Atherosclerosis, vol. 151, pp. 357-379, 2000.
. J. P. Segrest, L. Li, G. Anantharamaiah, S. C. Harvey, K. N. Liadaki, and V. Zannis, "Structure and function of apolipoprotein AI and high-density lipoprotein," Current opinion in lipidology, vol. 11, pp. 105-115, 2000.
. Y. Meng, S. Heybrock, D. Neculai, and P. Saftig, "Cholesterol handling in lysosomes and beyond," Trends in cell biology, vol. 30, pp. 452-466, 2020.
. P. Durrington and H. Soran, "Hyperlipidemia," in Metabolism of human diseases, ed: Springer, 2014, pp. 295-302.
. T. Skajaa, D. P. Cormode, E. Falk, W. J. Mulder, E. A. Fisher, and Z. A. Fayad, "High-density lipoprotein–based contrast agents for multimodal imaging of atherosclerosis," Arteriosclerosis, thrombosis, and vascular biology, vol. 30, pp. 169-176, 2010.
. K. Öörni, S. Lehti, P. Sjövall, and P. T. Kovanen, "Triglyceride-rich lipoproteins as a source of proinflammatory lipids in the arterial wall," Current medicinal chemistry, vol. 26, pp. 1701-1710, 2019.
. S. Rahmany and I. Jialal, "Biochemistry, Chylomicron," 2019.
. J. Shen, X. Tong, N. Sud, R. Khound, Y. Song, M. X. Maldonado-Gomez, et al., "Low-density lipoprotein receptor signaling mediates the triglyceride-lowering action of Akkermansia muciniphila in genetic-induced hyperlipidemia," Arteriosclerosis, thrombosis, and vascular biology, vol. 36, pp. 1448-1456, 2016.
. S. S. Carr, A. J. Hooper, D. R. Sullivan, and J. R. Burnett, "Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment," Pathology, vol. 51, pp. 148-154, 2019.
. F. Chiarelli and M. L. Marcovecchio, "Insulin resistance and obesity in childhood," European Journal of Endocrinology, vol. 159, pp. S67-S74, 2008.
. H. O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel, and A. D. Baron, "Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance," The Journal of clinical investigation, vol. 97, pp. 2601-2610, 1996.
. E. H. ElHabashi, S. Esmat, F. El-Aguizy, and E. F. Ataya, "Dietary Patterns, Prevalence and Predictors of Obesity among Medical Students in Cairo University," Egyptian Journal of Nutrition and Health, vol. 15, pp. 91-111, 2020.
. S. Elmaoğulları, D. Tepe, S. A. Uçaktürk, F. K. Kara, and F. Demirel, "Prevalence of dyslipidemia and associated factors in obese children and adolescents," Journal of clinical research in pediatric endocrinology, vol. 7, p. 228, 2015.
. F. M. Cizmecioglu, S. Hatun, and S. Kalaça, "Metabolic syndrome in obese Turkish children and adolescents: comparison of two diagnostic models," The Turkish journal of pediatrics, vol. 50, p. 359, 2008.
. E. d. Franca and J. G. B. Alves, "Dyslipidemia among adolescents and children from Pernambuco-Brazil," Arquivos brasileiros de cardiologia, vol. 87, pp. 722-727, 2006.
. R. Monge-Rojas, "Serum lipids and lipoprotein levels in Costa Rican 13-18 year-old teenagers," Archivos latinoamericanos de nutricion, vol. 51, pp. 236-243, 2001.
. S. Yang, J. S. Hwang, H. K. Park, H. S. Lee, H. S. Kim, E. Y. Kim, et al., "Serum lipid concentrations, prevalence of dyslipidemia, and percentage eligible for pharmacological treatment of Korean children and adolescents; data from the Korea National Health and Nutrition Examination Survey IV (2007–2009)," PloS one, vol. 7, p. e49253, 2012.
. F. Taheri, T. Chahkandi, T. Kazemi, B. Bijari, M. Zardast, and K. Namakin, "Lipid profiles and prevalence of dyslipidemia in Eastern Iranian adolescents, Birjand, 2012," Iranian journal of medical sciences, vol. 40, p. 341, 2015.
. S. Zhao, Y. Wang, Y. Mu, B. Yu, P. Ye, X. Yan, et al., "Prevalence of dyslipidaemia in patients treated with lipid-lowering agents in China: results of the DYSlipidemia International Study (DYSIS)," Atherosclerosis, vol. 235, pp. 463-469, 2014.
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