Endurance of Endometriosis Patients after Surgery Using Survival Analysis

  • Citra Komang Sari Department of Statistics, Faculty of Mathematics and Natural Science, IPB University, Raya Dramaga street, 16680 Bogor, Indonesia
  • Hari Wijayanto Department of Statistics, Faculty of Mathematics and Natural Science, IPB University, Raya Dramaga street, 16680 Bogor, Indonesia
  • I Made Sumertajaya Department of Statistics, Faculty of Mathematics and Natural Science, IPB University, Raya Dramaga street, 16680 Bogor, Indonesia
Keywords: Deep Infiltrating Endometriosis, Endometriosis, Extended Cox Model

Abstract

Endometriosis is a disease that affects reproductive-aged women. Endometriosis is not a deadly disease but can cause severe pain and infertility. The delay in diagnosis caused the lesion was already quite large by the time it was discovered. One of reasons for the delay in diagnosis is assumption that pain during menstruation is normal. Nowadays, solution for this disease is surgery because cure has not been found yet. However, it does not guarantee recurrence of endometriosis. Therefore, this study aims to look for factors that affect the resilience of endometriosis patients since surgery using extended cox models. Results showed that age, surgical history, die, the largest lesion, endometriosis type, and type of surgery significantly affect on recurrence. Patients who have history of surgery, will have a risk of relapse 2.45 times compared to not have surgical history. Someone who has grade III or IV is 2.34 times as likely to relapse as someone who has grade I or II. Laparoscopic patients have 2.27 times more likely to experience recurrence than laparotomy. Someone who has higher age has lower risk of recurrence assuming other covariates are constant.

References

A. Elnouri. (2016, May). “Endometriosis and Fertility.” European Journal & Gynecology and Reproductive Biology. [On-line]. 206, pp. 251. Available: https://doi.org/10.1016/j.ejogrb.2016.07.005. [Jan. 20, 2020]

. H. Hendarto. Endometriosis dari Aspek Teori sampai Penanganan Klinis. Surabaya, Indonesia: Airlangga University Press, 2015.

. T.W. Belnap, A.P. Brown, M.K. Dodson, J. Frandsen, D.K. Gaffney, M.M. Lum, et al. (2015, Jun.). “Survival Analysis of Cancer Patients with FIGO Stage IIIA Endometrial Cancer.” American Journal of Clinical Oncology. [On-line]. 38 (3), pp. 283-288. Available: https://doi.org/10.1097/coc.0b013e31829c12be [Jan. 17, 2020].

. M. Klein, D.G. Kleinbaum. Survival Analysis: A self-Learning Text. New York, US: Springer, 2012.

. Nurfain, S.W. Purnami. (2017, Mar.). “Analisis Regresi Cox Extended pada Pasien Kusta di Kecamatan Brondong Kabupaten Lamongan.” Jurnal Sains dan Seni ITS. [On-line]. 6(1), pp. 94-100. Available: http://dx.doi.org/10.12962/j23373520.v6i1.22440 [Nov. 22, 2020].

. A. Mathew, J. Krishna, P.S. George. (2017, Jun) “Cancer Survival Estimates Due to Non-Uniform Loss to Follow-Up and Non-proportional Hazards. Asian Pacific Journal of Cancer Prevention. [On-line]. 18(6), pp. 1493-1497. Available: https://dx.doi.org/10.22034/APJCP.2017.18.6.1493 [Jun. 25, 2021]

. N. Lasmini. “Model Regresi Cox dengan Hazard Tak Proporsional dan Aplikasinya pada Waktu Ketahanan Pengguna Narkoba.” B.S. Thesis, IPB University, Indonesia, 2013.

. E. Suparman, E. Suparman. (2012, July). “Penatalaksanaan Endometriosis.” Jurnal Biomedik. [On-line]. 4 (2), pp. 69-78. Available: https://doi.org/10.35790/jbm.4.2.2012.754 [Jan. 20, 2020].

. L. Kiesel, M. Langhardt, F. Petraglia, T. Rabe, K.W Schweppe, J. Woziwodzki. (2013). “Endometriosis-Pathogenesis, Diagnosis and Therapeutic Options for Clinical and Ambulatory Care.” Journal of Reproductive Medicine and Endocrinology. [On-line]. 10(1), pp. 102-119. Available: https://www.kup.at/kup/pdf/11285.pdf [Feb. 9, 2020].

. M.R. Akhoond, M. Ashrafi, S.J. Sadatmahalleh, M. Talebi. (2016, April). “Evaluation of Risk Factor Associated with Endometriosis in Infertile Women.” International Journal of Fertility and sterility. [On-line]. 10(1), pp. 11-21. Available: https://dx.doi.org/10.22074%2Fijfs.2016.4763 [Jan. 17, 2020].

. J. Harlan. Analisis Survival. Depok, Indonesia: Gunadarma, 2017.

. A. Kazemnejad, A. Mottagi, Sj. Sadatmahalleh, S. Youseflue. (2019, Sep). “The Association of Food Intake with Endometriosis Risk in Iranian Woman: A case-control study.” International Journal of Reproductive Biomedicine. [On-line]. 17(9), pp 661-670. Available: https://doi.org/10.18502/ijrm.v17i9.5102 [Jun, 25. 2021].

. N. Eliyati, S.I. Maiyanti, O. Dwipurwani, S.W. Hamidah. (2021, March). “Model Regresi Cox untuk Menganalisis Pengaruh Faktor Asupan Makanan terhadap Risiko Kekambuhan Endometriosis. Barekeng: Jurnal Imu Matematika dan Terapan. [On-line]. 15(1), pp 103-114. Available: https://doi.org/10.30598/barekengvol15iss1pp103-114 [Jun. 3, 2021].

. A. Ribeiro-Silva, C.M. Bonocher, J. Moela, J.C. Rosa-e-Silva, M.L. Montenegro, M.O. Brunaldi, R.A. Ferriani, R.L. Portella. (2019, Jun). “Efect of Physical Exercise on Endometriosis Experimentallly Induce in Rats.” Reproductive Sciences. [On-line]. 26(6), pp 785-793. Available: https://doi.org/10.1177/1933719118799205 [Jun. 25, 2021].

Published
2021-07-12
Section
Articles