Expression of PD-L1 and Relationship with Tumor-Infiltrating Lymphocytes and Metastatais in Serous Ovarian Carcinoma

  • Riadi Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Rina Masadah Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Berti J. Nelwan Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Keywords: PD-L1, Ovarian Cancer, LGSC, HGSC, Metastasis, TILs

Abstract

Ovarian serous carcinoma is the most common ovarian malignancy in women, and most of them are diagnosed at an advanced stage and have metastasis. With current therapy, the 5-year mean survival rate is still not satisfying and opening a new approach. Immunotherapy using anti-PD-L1 is widely used in various types of malignancies. The use of PD-L1 in serous ovarian carcinoma is still quite limited. This study aimed to explore the potential of immunotherapy by assessing the expression of PD-L1 in serous ovarian carcinoma. Immunohistochemical performed to analyze PD-L1 dan compared with metastases incidence and tumor immune response. PD-L1 expression appeared to be stronger in high-grade serous carcinoma than low-grade serous carcinoma, but there was no statistical difference (p 0.539). There was a correlation between PD-L1 and metastasis incident (p 0.015) in high-grade serous ovarian carcinoma. There was a significant correlation between PD-L1 and tumor-infiltrating lymphocytes. PD-L1 in serous carcinoma has a strong relationship with TILs, opens up the possibilities of using anti-PD-L1 on serous carcinoma. PD-L1 expression in high-grade serous carcinoma has a relationship with the incidence of metastases.

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Published
2021-05-01
Section
Articles