Sub-chronic Toxicity of Anti-ectoparasitic Formulation Comprising Cymbopogon Citrates Essential Oil and Jatropha Curcas Fixed Oil in Swiss Albino Mice
AbstractEctoparasites are found widely distributed in all agro-ecological zones of Ethiopia. The problems they cause can be alleviated through the use of traditional medicinal plants. Cymbopogon citratus is one of the traditional herbs commonly used for such purpose. This study was conducted to profile safety of the C. citratus based anti ectoparasitic formulation. The toxicity study had shown significant weight change in animal group that received 3.75% of the formulation. There were also significant changes in serum lipid profiles of treated group animals compared with the control. The level of uric acid in animals treated with 3.75% of the formulation showed significant increase compared with the control. Liver and kidney histopathology of both treatment group animals revealed few mononuclear leucocytic infiltrations. The blood cell parameters and different biochemical findings had revealed no sign of toxicity. However; other measured parameters like the body weight, histological and some biochemical findings had shown both significant and insignificant sign of toxicities. Therefore; it is important to consider the effect of the formulation in prolonged treatment on body weight, uric acid excretion and lipid metabolism.
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