Tartaric Acid Synthetic Derivatives for Multi-Drug Resistant Phytopathogen Pseudomonas and Xanthomonas Combating

  • Bella Babayan National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia, National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia, ‘’Armbiotechnology” Scientific And Production center (SPC), National Academy of Sciences (NAS), Republic of Armenia (RA) ), Yerevan, 0019, Republic of Armenia
  • Aram Mikaelyan National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia
  • Nona Asatryan National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia
  • Tigran Soghomonyan National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia
  • Allen Baghdasaryan National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia
  • Marina Melkumyan ’’Armbiotechnology” Scientific And Production center (SPC), National Academy of Sciences (NAS), Republic of Armenia (RA) ), Yerevan, 0019, Republic of Armenia
  • Samvel Bagdasaryan ’’Armbiotechnology” Scientific And Production center (SPC), National Academy of Sciences (NAS), Republic of Armenia (RA) ), Yerevan, 0019, Republic of Armenia
  • Anna Grigoryan Russian-Armenian University (RAU) ), Yerevan 0051, Republic of Armenia, National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia, National Polytechnic University of Armenia (NPUA), Yerevan 0009, Republic of Armenia
Keywords: phytopathogen, tartaric acid complex salts, tartaric acid imides, Pseudomonas, Xanthomonas, multi-drug resistance

Abstract

The resistance to antimicrobial preparations, according the WHO reports of recent years, is becoming the one of the most actual healthcare problems of this century. Nevertheless, the key role of antibiotics diversity increase, as well as the increase of their application scopes, the initial origin of antimicrobial resistance problem is the versatility of adaptation mechanisms potential of all microorganisms, including intraspecific gene horizontal transfer and quorum sensing. Thus, the actuality of search of new, ecologically safe and harmless for human health antimicrobial agents, among the natural and semisynthetic compounds, is being significantly increased. One of the prospective directions in these research is the derivatization of aldaric acids, isolated from plants different species, as the native antibacterial active substances, such as like: citric, acetic, tartaric, lactic.   In current research, 7 new derivatives of natural tartaric acid (TA): cyclohexylimide, benzylimide, phenylimide, benzyl mono amino salt, cyclohexyl mono amino salt, phenyl amino salt and mono ethanol amino salt of TA were tested on different strains from 6 subtypes of 3 species of phytopathogenic multi-drug resistant Xanthomonas and Pseudomonas. During the research it was detected the significant antimicrobial effect of studied compounds against the range of phytopathogens which are resistant to antibiotics from different classes and generations (ciprofloxacin, chloramphenicol, ceftriaxone, azithromycin, etc.). It was detected the higher efficiency of cyclohexyl- derivatives in comparison with mono ethanol-, phenyl- and benzyl- derivatives.

References

. A.T. Adesoji. Ogunjobi A.A., Olatoye I.O. “Molecular characterization of selected multidrug resistant Pseudomonas from water distribution systems in southwestern Nigeria”, Ann Clin Microbiol Antimicrob., 14, pp. 39, 2015.

. N.G.E. Chakhtoura. Therapies for multidrug resistant and extensively drug-resistant non-fermenting gram-negative bacteria causing nosocomial infections: a perilous journey toward “molecularly targeted” therapy, Expert Rev Anti Infect Ther., 16(2), pp. 89–110, 2018.

. R.-D. Jeong, E.-H. Chu, G.W. Lee, J.M. Park, H.-J. Park. "Effect of gamma irradiation on Pseudomonas syringae pv. tomato DC3000 – short communication", Plant Protection Science. 52 (2), pp. 107–112, 2016.

. M.P. Castañeda-Ojeda, A. Moreno-Pérez, C. Ramos, E. López-Solanilla. Suppression of Plant Immune Responses by the P. savastanoi pv. savastanoi NCPPB 3335 Type III Effector Tyr Phosphatases HopAO1 and HopAO2, Front. Plant Sci., 8(680), 1-15, 2017.

. J.M. Young, JP. Wilkie, DS. Park, DR. Watson. "New Zealand strains of plant pathogenic bacteria classified by multi-locus sequence analysis; proposal of X. dyei sp. nov". Plant Pathol., 59 (2): 270–281, 2010.

. N. Ah-You, L. Gagnevin, PA. Grimont, S. Brisse, X. Nesme, F. Chiroleu, et al. "Polyphasic characterization of xanthomonads pathogenic to members of the Anacardiaceae and their relatedness to species of Xanthomonas". Int. J. of Syst. & Evol. Microbiol. 59 (Pt 2): 306-18, 2009.

. J.L. Rademaker, FJ. Louws, MH. Schultz, U. Rossbach, L. Vauterin, J. Swings, et al. "A comprehensive species to strain taxonomic framework for Xanthomonas". Phytopathology. 95 (9): 1098–111. Sep. 2005.

. Xu Ying, Luo Qing-quan, Zh. Ming-Guo. Identification and Characterization of Integron-Mediated Antibiotic Resistance in the Phytopathogen X. oryzae pv. oryzae, PLoS One.; 8(2): e55962, 2013.

. G.B. Martin. "Suppression and Activation of the Plant Immune System by P. syringae Effectors AvrPto and AvrPtoB". Effectors in Plant–Microbe Interactions. pp. 123–154, 2011.

. G.G. De Araujo, F. Rodrigues, F.L.T. Gonçalves, D. Galante. ''Survival and ice nucleation activity of P. syringae strains exposed to simulated high-altitude atmospheric conditions'', Scientific Reports, vol. 9:7768, pp. 1-11, 2019.

. G.W. Sundin, N. Wang. Antibiotic Resistance in Plant-Pathogenic Bacteria, Annu Rev Phytopathol, vol. 25;56, pp. 161-180, 2018.

. C. Cholet, S. Claverol, O. Claisse, A. Rabot, A. Osowsky, V. Dumot, G. Ferrari, L. Gény. “Tartaric acid pathways in Vitis vinifera L. (cv. Ugni blanc): a comparative study of two vintages with contrasted climatic conditions”, BMC Plant Biol. vol. 16 pp. 144, 2016.

. WHO: “Ten Threats to global health in 2019” (https://www.who.int/emergencies/ten-threats-to-global-health-in-2019), 2019.

. SQ. An, N. Potnis, M. Dow, FJ. Vorhölter, YQ. He, A. Becker, et al. "Mechanistic insights into host adaptation, virulence and epidemiology of the phytopathogen Xanthomonas". FEMS Microbiology Reviews: fuz 024, Oct. 2019.

. S. DeBolt, D.R. Cook, C.M. Ford. ”L-Tartaric acid synthesis from vitamin C in higher plants”, Proc Natl Acad Sci U S A., vol.103(14) pp. 5608–5613, 2006.

. C. Nunes, A. Duarte, D. Caixeirinho. “Organic Acids Concentration in Citrus Juice from Conventional versus Organic Farming”, Acta Hort. (ISHS), 933, pp. 601-606, 2012.

. R.G. Maroun, H.N. Rajha, E. Vorobiev and N. Louka. 7 - Emerging Technologies for the Recovery of Valuable Compounds From Grape Processing By-Products, Handbook of Grape Processing By-Products Sustainable Solutions, pp. 155-181, 2017.

. M. Malik, Sh. W. Khan, M. Arfan, J. H. Zaidi, A. Bano, F. Ullah. “Biological Evaluation of Chiral Amides Synthesized from Diacetyl-L-tartaric Acid and Aromatic Amines”, Asian Journal of Chemistry, 25(2) pp. 745-748, 2013.

. Sh.W. Khan, S. Naz, J.H. Zaidi, N. Ambreen, K.M. Khan, Sh. Perveen, GH.A. Miana. “Synthesis and Antimicrobial Activity of Chiral Imides from Diacetyl-L-Tartaric Acid Anhydride and Different Amino Acids”, Journal of Pharmacy Research, 5(1), pp. 646-650, 2012.

. A.R. Mikaelyan, N.L. Asatryan, S.A. Bagdasaryan, B.G. Babayan. “Antimicrobial Activity of Newly Synthesized Derivatives of Tartaric Acid Against the Multidrug Resistant Soil Strains of Pseudomonas and Stenotrophomonas”, ARICBE/ARICPAS-2019, Cambridge Univ., Abstract Book, Cambridge, UK, 1-2. 2019.

. B.G. Babayan, A.R. Mikaelyan, S.M. Shahinyan. S.A. Bagdasaryan. “Tartaric Acid New Derivatives Effect Against the Soil Pseudomonas and Stenotrophomonas as A Model for Research of Cave Infection Bacteria Antibiotic Resistance Combating, the book of Abstracts of "Int. Conf. ''Caves as Natural & Cultural Monuments'', Yerevan, RA, pp. 22 -23, 2019.

. N.A. Dashchyan, N.L. Asatryan, G.F. Galstyan, A.R. Mikaelyan. “Obtaining Bioactive Additives of Cyclic Structure on the Basis of Optically Active Tartaric Acid”, Bulletin of NPUA, Coll. of Sci. papers, 2, pp. 682-683, 2014

. B. Babayan. “The Plasmid Differences In Multi-Drug Resistant Opportunistic Pathogenic Soil Strains of Pseudomonas and Stenotrophomonas,” EJMN, 3(1), pp. 23-28, 2019.

. M.O. Birger. “Handbook of microbial.l & virology. methods of research”, pp.303-310, 354. 1982

. K.D. Chaudhary, A. Khulan, J. Kim."Development of a novel cultivation technique for uncultured soil bacteria", Scientific Reports, vol.9 (6666), pp. 10 11, 2019.

. S.D. Ellis, MJ. Boehm, D. Coplin. "Bacterial Diseases of Plants". Ohio St. Univ. Fact Sheet, 2008.

Published
2020-05-20
Section
Articles