Estimation of TNF- α and LDH in Chronic Periodontitis Patients in Mosul

  • Mahmoud Y. M. Taha Professor, Department of Dental Basic Sciences, College of Dentistry, Mosul University, Mosul, Iraq
  • Heba F. Hamodat Assist. lecturer, Department of Dental Basic Sciences, College of Dentistry, Mosul University
Keywords: Chronic periodontitis, TNF-α, LDH, periodontal parameters


The objective of the study is to estimate salivary concentration of TNF-α and LDH level in chronic periodontitis and control group, and correlate them with periodontal parameters. The study group consisted of 44 patients suffering from chronic periodontitis, aging between ≤16-45 years old and 40 control samples collected from healthy individuals ranged between 16-40 years old .Chronic periodontitis was assessed on the basis of several periodontal parameters, including probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing  (BOP) and plaque index (PI). 5ml of unstimulated saliva was collected from patients and control groups to measure salivary biomarkers by ELISA technique. the mean concentrations of TNF-α in the study and control groups were (6.9pg/ml) and (5.6 pg/ml) respectively, data analysis showed no significant difference between the two groups (P< 0.05), and the mean LDH level in chronic periodontitis was (7.7855) and in control group the mean was (0.5555)   and the difference was highly significant )p≤ 0.000). Salivary TNF-α and LDH showed positive correlation with clinical periodontal parameters.


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