Relationship of Survivin Expression with Histopathological Grade and Events of Metastasis to Omentum in Serous Carcinoma of Ovary
Keywords:
survivin, serous carcinoma, ovary, metastasisAbstract
Ovarian cancer is the third most common cancer in Indonesia after cervical and breast cancer with the increasing incidence and mortality. The purpose of this study was to determine the relationship of survivin expression with the degree of histopathology and the incidence of metastasis to the omentum using immunohistochemical examinations. This is a cross-sectional study using 72 paraffine blocks of serous carcinoma of ovary without and with metastasis to omentum in Makassar, Indonesia during 2015-2018. Survivin was positive in tumor cells with a different degree based on the grade of histopathology and the incidence of metastases to the omentum. There was a significant difference between survivin expression with the degree of histopathology and the incidence of metastases to the omentum in serous carcinoma of ovary (p = 0.000).
References
. Siegel, R., Naishadham, D. & Jemal,A. 2013. Cancer Statistics, 2013. CA Cancer J Clin, 63, 11-30.
. Siegel, R.L.,Miller, K.D. & Jemal, A.2015. Cancer Statistics, 2015. CA Cancer J Clin, 65, 5-29
. Bartlett, J.M. S.2000. Ovarian cancer methods and protocols. In Bartlett, J.m.S.(ed). Ovarian Cancer : Methods and protocols. Humana press.
. Ana Noviani. 2014. Yayasan Kanker Indonesia berikan tes pap smear dan IVA gratis. Lifestyle Bisnis com.
. Koshiyama,M., Matsumura,N. & Konishi, I. 2014. Recent concepts of ovarian carcinogenesis : type I and type II. BioMed research international, 2014.
. Christie, M. & Oehler, M. K. 2006. Molekular pathology of epithelial ovarian cancer. British Menopause Society Journal, 12, 57-63.
. Altieri, Dario C.2015.”Survivin – The Inconvenient IAP.” Seminars in Cell and Developmental Biology 39. Elsevier Ltd : 91-96. doi : 10.1016/j. semcdb. 2014. 12.007
. Wiredu EK, Armah BH. Cancer mortality pattern in Ghana : a 10-year review of autopsies and hospital mortality. BMC Public Health. 2006; 6:159
. Wilian WH, Lawrence SA & John F : Menopause, Novoks, Gynecology : Jonathan SB : Lippincott Williams and Wilkins, Philadelphia. Thirteenth Edition. 1109-1139, 2002.
. RK Pathak & Purnima Parasha, Age at Menopause and associated BIoSocial factors of helath in Punjabi women. The open anthropology journal. 2013;3: 172-180.
. Colnaghi, Rita, Claire M.Connel, R M A Barret, and Sally P.Wheatley. 2006. “ Separating the Anti Apoptotic and Mitotic Roles of Survivin .” Journal of Biological Chemistry 281 ( 44 ): 33450-56. Doi:10.1074/jbc.C600164200
. Hirotomi Yamamoto, Chew Yee Ngano, Morito Mondeu.” Cancer Cells Survive with Survivin.” Japanese cancer Association (2008).doi : 10.1111/j.1349-7006.2008.00870.
. Vang R, Shih I, Kurman RJ, Ovarian Low Grade and High Grade Serous Carcinoma : Pathogenesis, Clonopathologic and Molekular Biologic Features,and Diagnostic Problems. 2009. NIH Public Access. Adv anat pathol. 2009 September; 16(5) : 267-282.
. Lv, Yong-Gang, Fang Yu, Qing Yao, Jiang-Hao Chen, and Ling Wang. 2010. “ The Role of Survivin in Diagnosis, Prognosis and Treatment of Breast Cancer (2):100-110.
. Sanhueza, C., S. Wehinger, J. Castillo Bennett, M. Valenzuela, G. I. Owen, and A.F.G. Quest. 2015. “The Twisted Survivin Connection to Angiogenesis.” Molekular Cancer 14 (1). MolekularCancer :198.doi: 10.1186/s12943-015-0467-1.
. Zaloudek, C. F. 2007. Ovary, fallopian tube, and broad and round ligaments. In : Fletcher, C. D.M. (ed.). Diagnostik histopathology of tumors. 3rd ed. Edinburgh : Churchill Livingstone Elsevier.
. Jaiswal, Praveen Kumar,Apul goel, and Rama Devi Mittal. 2015.” Survivin: A Molekular Biomarker in Cancer.” Indian Journal of Medical Research 141(april) : 389-97.doi : 10.4103/0971-5916.159250.
. Di Palma, T.,Filippone,M.G., Pierantoni, G.M., Fusco,A.,Soddu,S. & Zannini, M.2013. Survivin has a critical role in epithelial cell survival and proliferation. Cell Death Dis, 4, e729
. Mita, Alain C.,Monica M.Mita, Steffan T.Nawrocki, and Francis J.Giles. 2008. “Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics.” Clinical Cancer Research 14 (16): 5000-5005. doi:10.1158/1078-0432. CCR-08-0746.
. Ambrosini, G, C Adida, G Sirugo, and D C Altieri. 1998. “Induction of Apoptosis and Inhibition of Cell Proliferation by Survivin Gene targeting”. J. Biol. Chem. 273 (18): 11177 - 82. http://www.ncbi.nlm. nih. Gov / pubmed / 0009556606.
. Di Palma, T.,Lucci, V., De Cristofaro, T., Filippone, M.G. & Zannini, M. 2014. A Role for Survivin in the tumorigenic phenotype of ovarian cancer cells. BMC Cancer, 14,292
. Danuta Plewka, Beata J, Michal M, Edyta B. “Survivin in Ovary Tumor”.Prace Oryginalne Ginekologia (2015).Ginekol Pol.2015,86,525-530. doi : 10.17772/gp/57855.
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