Relationship of Survivin Expression with Histopathological Grade and Events of Metastasis to Omentum in Serous Carcinoma of Ovary

Authors

  • Upik Anderiani Miskad Faculty of Medicine, Muhammadiyah University, Makassar, Indonesia
  • Nurlinda Nurlinda Anatomical Pathology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Berti Julian Nelwan Nelwan Anatomical Pathology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Rina Masadah Masadah Anatomical Pathology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Mahmud Ghaznawie Ghaznawie Anatomical Pathology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Muh Husni Cangara Cangara Anatomical Pathology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Dasril Daud Daud Pediatric Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Keywords:

survivin, serous carcinoma, ovary, metastasis

Abstract

Ovarian cancer is the third most common cancer in Indonesia after cervical and breast cancer with the increasing incidence and mortality. The purpose of this study was to determine the relationship of survivin expression with the degree of histopathology and the incidence of metastasis to the omentum using immunohistochemical examinations. This is a cross-sectional study using 72 paraffine blocks of serous carcinoma of ovary without and with metastasis to omentum in Makassar, Indonesia during 2015-2018. Survivin was positive in tumor cells with a different degree based on the grade of histopathology and the incidence of metastases to the omentum. There was a significant difference between survivin expression with the degree of histopathology and the incidence of metastases to the omentum in serous carcinoma of ovary (p = 0.000).

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Published

2019-11-11

How to Cite

Miskad, U. A., Nurlinda, N., Nelwan, B. J. N., Masadah, R. M., Ghaznawie, M. G., Cangara, M. H. C., & Daud, D. D. (2019). Relationship of Survivin Expression with Histopathological Grade and Events of Metastasis to Omentum in Serous Carcinoma of Ovary. International Journal of Sciences: Basic and Applied Research (IJSBAR), 48(5), 107–113. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/10431

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