Medicinal Uses of Cassia Sieberiana; A Review


  • Mary-Ann Archer Department of Pharmaceutics, Centre for Plant Medicine Research, P.O. Box 73, Akuapem-Mampong, Ghana
  • Tonny Asafo Agyei Department of Pharmaceutics, Centre for Plant Medicine Research, P.O. Box 73, Akuapem-Mampong, Ghana
  • Susana Oteng Mintah Department of Microbiology, Centre for Plant Medicine Research, P.O. Box 73, Akuapem-Mampong, Ghana
  • Peter Atta-Adjei Junior Department of Pharmacology and toxicology, Centre for Plant Medicine Research, P.O. Box 73, Akuapem-Mampong, Ghana
  • Doris Kumadoh
  • Jerry Asiedu-Larbi


Cassia sieberiana, botanical description, pharmacology, toxicity, phytochemical constituents, Review


Ethnomedicinal importance: Cassia sieberiana, mostly found in Africa has been used in traditional medicine as purgative, diuretic, analgesic, antibiotic, anti-inflammatory agent and many others for decades. This review focusses on discussions about its traditional therapeutic benefits, Ethnopharmacological studies, pharmacological, toxicological and phytochemical relevance. Materials and Methods: Electronic database such as PubMed, SciFinder, Science Direct, Google Scholar, Excerpta database and Springer were used in the search for filtered investigations on Cassia sieberiana. Results: The results from the various studies on Cassia sieberiana gave a detailed understanding of its constituents which serves as evidence for its therapeutic and safety importance as well as a source of novel compounds with therapeutic effects. Conclusion: This review on Cassia sieberiana is significant not only in providing a comprehensive data for continuous research but also will show untapped areas in the research on Cassia sieberiana.


D. S. Fabricant and N. R. Farnsworth, “The value of plants used in traditional medicine for drug discovery.,” Environ. Health Perspect., vol. 109, no. suppl 1, pp. 69–75, 2001.

S. Sasidharan, Y. Chen, D. Saravanan, K. M. Sundram, and L. Y. Latha, “Extraction, isolation and characterization of bioactive compounds from plants’ extracts,” African J. Tradit. Complement. Altern. Med., vol. 8, no. 1, 2011.

H.-J. von Maydell, Trees and shrubs of the Sahel, their characteristics and uses., no. 196. 1986.

N. R. Mshana, Traditional medicine and pharmacopoeia: contribution to the revision of ethnobotanical and floristic studies in Ghana. Organization of African Unity/Scientific, Technical & Research Commission, 2000.

L. J. G. Van der Maesen, “Cassia sieberiana DC,” Rec. from PROTA4U. Schmelzer, GH Gurib-Fakim, A.(Editors). PROTA (Plant Resour. Trop. Africa/Ressources végétales l’Afrique Trop. Wageningen, Netherlands, 2007.

J. P. Hans, “Trees and Shrubs of the Sahel: Their characteristic and uses Print by Typo-druck,” Hans-Jurgen Von Maydell, Ger., 1990.

T. K. Lim, “Garcinia macrophylla,” in Edible Medicinal And Non-Medicinal Plants, Springer, 2012, pp. 71–75.

A. A. Olapade, O. A. Ajayi, and I. A. Ajayi, “Physical and chemical properties of Cassia sieberiana seeds.,” Int. Food Res. J., vol. 21, no. 2, 2014.

I. Toma, Y. Karumi, and M. A. Geidam, “Phytochemical screening and toxicity studies of the aqueous extract of the pods pulp of Cassia sieberiana DC.(Cassia Kotchiyana Oliv.),” African J. Pure Appl. Chem., vol. 3, no. 2, pp. 26–30, 2009.

G. H. Sam, M. L. K. Mensah, and N. Nyakoa-Ofori, “Pharmacognostic studies and standardization of Cassia sieberiana roots,” Pharmacogn. J., vol. 3, no. 21, pp. 12–17, 2011.

L. Traore, Y.-A. Bekro, J.-L. Pirat, and J. A. Mamybeva-Bekro, “Study of crude extracts from Cassia sieberiana root bark and Khaya grandifoliola trunk bark: phytochemical screening, quantitative analysis and radical scavenging activity,” Int. J. Curr. Pharm. Res., vol. 7, no. 3, pp. 22–26, 2015.

K. Donkor, L. N. K. Okine, W. K. M. Abotsi, and E. Woode, “Antiinflammatory and anti-nociceptive effects of ethyl acetate fraction of root bark of cassia sieberiana dc in murine models,” Pharmacologia, vol. 4, no. 4, pp. 301–310, 2013.

A. Traore, S. Ouedraogo, M. B. Belemlilga, A. Kabore, and I. P. Guissou, “Phytochemical analysis and ovicidal activity of Cassia sieberiana, Guiera senegalensis and Excoecaria grahamii extracts,” African J. Pharm. Pharmacol., vol. 11, no. 44, pp. 554–560, 2017.

E. T. Nartey, M. Ofosuhene, W. Kudzi, and C. M. Agbale, “Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent,” BMC Complement. Altern. Med., vol. 12, no. 1, p. 65, 2012.

H. Bello, Z. Mohammed, and U. A. Katsayal, “Pharmacognostic evaluation of the root Cassia sieberiana DC: A promising ethnomedicinal plant,” J. Pharmacogn. Phytochem., vol. 5, no. 3, p. 270, 2016.

D. A. Awomukwu, B. L. Nyananyo, A. I. Ikpeama, and C. U. Adieze, “Comparative chemical constituents of some Cassia species and their pharmacognistic importance in South Eastern Nigeria,” Sci. J. Chem., vol. 3, no. 3, pp. 40–49, 2015.

S. Jibril, H. M. Sirat, and N. Basar, “Bioassay-Guided Isolation of Antioxidants and α-Glucosidase Inhibitors from the Root of Cassia sieberiana DC (Fabaceae),” Rec. Nat. Prod, vol. 11, pp. 406–410, 2017.

K. Kpegba et al., “Epiafzelechin from the root bark of Cassia sieberiana: Detection by DART mass spectrometry, spectroscopic characterization, and antioxidant properties,” J. Nat. Prod., vol. 74, no. 3, pp. 455–459, 2010.

H. M. Manga, D. Brkic, D. E. P. Marie, and J. Quetin-Leclercq, “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg.(Euphorbiaceae),” J. Ethnopharmacol., vol. 92, no. 2–3, pp. 209–214, 2004.

H. Mavar-Manga, D. Chapon, S. Hoet, S. Block, D. Pauw-Gillet, and J. Quetin-Leclercq, “N1, N2, N3-trisisopentenyl guanidine and N1, N2-diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg.(Euphorbiaceae) root barks,” Nat. Prod. Commun. an Int. J. Commun. Rev., vol. 1, no. 12, p. 1097, 2006.

G. Y. Sy et al., “Analgesic and anti-inflammatory activity of aqueous root extract of Cassia sieberiana DC (Caesalpiniaceae),” African J. Pharm. Pharmacol., vol. 3, no. 12, pp. 651–653, 2009.

E. Sabina, S. Chandel, and M. K. Rasool, “Evaluation of analgesic, antipyretic and ulcerogenic effect of Withaferin A,” Int J Integr Biol, vol. 6, no. 2, pp. 52–56, 2009.

O. Silva, E. Ferreira, M. Vaz Pato, and E. Gomes, “Guinea-Bissau’s plants: in vitro susceptibility studies on Neisseria gonorrhoeae,” Int. J. Pharmacogn., vol. 35, no. 5, pp. 323–328, 1997.

S. M. Thomazzi et al., “Antinociceptive and anti-inflammatory activities of Bowdichia virgilioides (sucupira),” J. Ethnopharmacol., vol. 127, no. 2, pp. 451–456, 2010.

E. W. C. Trease G.E, A Textbook of Pharmacognosy, 13th Editi. London: Bailliere Tindall Ltd., 1989.

E. Woode, E. Boakye-Gyasi, G. K. Ainooson, C. Ansah, and M. Duwiejua, “Anti-Nociceptive Effects and the Mechanism of Palisota hirsuta,” Int. J. Pharmacol., vol. 5, no. 2, pp. 101–113, 2009.

C. J. Woolf, “Pain: moving from symptom control toward mechanism-specific pharmacologic management,” Ann. Intern. Med., vol. 140, no. 6, pp. 441–451, 2004.

W.-P. Wu et al., “Increased nociceptive response in mice lacking the adenosine A1 receptor,” Pain, vol. 113, no. 3, pp. 395–404, 2005.

N. J. Talley, “Novel mechanisms in functional dyspepsia,” World J. Gastroenterol. WJG, vol. 12, no. 5, p. 673, 2006.

A. D. Fall, W. Diatta, G. Sy, M. Lo, E. Bassene, and B. Faye, “Myorelaxant and antispasmodic activity of ethanolic total extract’s fractions of roots of Cassia sieberiana DC (Caesalpiniaceae) on isolated wistar rat ileum,” Dakar Med., vol. 50, no. 3, pp. 132–135, 2005.

I. M. Siregar and I. Miladiyah, “Protective effects of Cyclea barbata Miers leaves against aspirin-induced gastric ulcer in mice,” Universa Med., vol. 30, no. 2, pp. 88–94, 2016.

M. Elliott and K. Chithan, “The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer,” in The flavonoids advances in research since 1986, Routledge, 2017, pp. 619–652.

P. P. Rai and N. Abdullahi, “Occurrence of anthraquinone in Cassia species,” Niger. J. Pharm., vol. 9, pp. 160–165, 1978.

A. A. Elujoba and G. O. Iweibo, “Cassia podocarpa as substitute for official senna,” Planta Med., vol. 54, no. 04, p. 372, 1988.

T. C. Lou, “The Biological Assay Of Vegetable Purgatives: Part I.–Senna Leaf and Fruit and Their Preparations,” J. Pharm. Pharmacol., vol. 1, no. 1, pp. 673–682, 1949.

A. R. Latven, A. B. Sloane, and J. C. Munch, “Bioassay of cathartics. I. Emodin type,” J. Am. Pharm. Assoc., vol. 41, no. 10, pp. 548–552, 1952.

C. O. Ajayi, F. Funso-Babarimisa, and A. A. Elujoba, “Laxative activities of Cassia sieberiana and Senna obtusifolia,” African J. Tradit. Complement. Altern. Med., vol. 11, no. 4, pp. 44–47, 2014.

D. D. Richman, D. M. Margolis, M. Delaney, W. C. Greene, D. Hazuda, and R. J. Pomerantz, “The challenge of finding a cure for HIV infection,” Science (80-. )., vol. 323, no. 5919, pp. 1304–1307, 2009.

K. Peltzer, N. Friend-du Preez, S. Ramlagan, and H. Fomundam, “Use of traditional complementary and alternative medicine for HIV patients in KwaZulu-Natal, South Africa,” BMC Public Health, vol. 8, no. 1, p. 255, 2008.

D. A. Babb, L. Pemba, P. Seatlanyane, S. Charalambous, G. J. Churchyard, and A. D. Grant, “Use of traditional medicine by HIV-infected individuals in South Africa in the era of antiretroviral therapy,” Psychol. Health Med., vol. 12, no. 3, pp. 314–320, 2007.

J. L. Weaver, P. S. Pine, G. Dutschman, Y.-C. Cheng, K.-H. Lee, and A. Aszalos, “Prevention of binding of rgp120 by anti-HIV active tannins,” Biochem. Pharmacol., vol. 43, no. 11, pp. 2479–2480, 1992.

G. Nonaka et al., “Anti-AIDS agents, 2: inhibitory effect of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells,” J. Nat. Prod., vol. 53, no. 3, pp. 587–595, 1990.

R. E. Kilkuskie et al., “HIV and reverse transcriptase inhibition by tannins,” Bioorg. Med. Chem. Lett., vol. 2, no. 12, pp. 1529–1534, 1992.

M. M. Leteane et al., “Old plants newly discovered: Cassia sieberiana DC and Cassia abbreviata Oliv. Oliv. root extracts inhibit in vitro HIV-1c replication in peripheral blood mononuclear cells (PBMCs) by different modes of action,” J. Ethnopharmacol., vol. 141, no. 1, pp. 48–56, 2012.

A. Lozniewski and C. Rabaud, “Résistance Bactérienne aux Infections,” pp. 1–4, 2010.

M.-B. J. and B. Y. Traoré L, Boua BB, Guessennd NK, Kadja BA, “In vitro antibacterial potential of glycosidic and aglyconic crude extracts of Cassia sieberiana DC.(Cesalpiniaceae) and Khaya grandifoliola C. DC.(Meliaceae): A comparative survey,” 2015.

A. A. Marmonier, “Introduction aux techniques d’étude des antibiotiques,” Bactériologie Médicale, Tech. usuelles, pp. 227–236, 1990.

Z. Aliyu, M. Yusha’u, and B. S. Aliyu, “Anti malarial activity of Cassia sieberiana leaf extracts,” in Open Conference Proceedings Journal, 2013, vol. 4, pp. 72–76.

S. A. Ojokuku, W. O. Okunowo, and A. Apena, “Evaluation of the chemical composition of Khaya grandifoliola and Ficus capensis,” J. Med. Plants Res., vol. 4, no. 12, pp. 1126–1129, 2010.

S. Hassan and U. Mathesius, “The role of flavonoids in root–rhizosphere signalling: opportunities and challenges for improving plant–microbe interactions,” J. Exp. Bot., vol. 63, no. 9, pp. 3429–3444, 2012.

H. E. Mshelia, J. Sani, S. Abdullahi, M. L. Umaru, and D. J. Abiodun, “Phytochemical screening, free radical scavenging and antibacterial activity of Cassia sieberiana root bark extracts,” J. Pharm. Bioresour., vol. 14, no. 1, pp. 75–82, 2017.

A. M. Halilu ME, Obtober N, Balogun M, Namrita L, “Studies of in vitro antioxidant and cytotoxic activities of extracts and isolated compounds from Parinari curatellifolia (Chrysobalanaceae),” J. Nat. Sci. Res., vol. 3, no. 13, pp. 149–154, 2013.

K. Ulanowska, A. Tkaczyk, G. Konopa, and G. Węgrzyn, “Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains,” Arch. Microbiol., vol. 184, no. 5, pp. 271–278, 2006.

WHO, “World Malaria Report 2018. 4.,” Who, p. ISBN 978-92-4-156565-3, 2018.

A. Asase et al., “Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia sieberiana, Haematostaphis barteri, Mitragyna inermis and Pseudocedrela kotschyi,” Phyther. Res., vol. 22, no. 8, pp. 1013–1016, 2008.

N. Abdulrazak, U. I. Asiya, N. S. Usman, I. M. Unata, and A. Farida, “Anti-plasmodial activity of ethanolic extract of root and stem back of Cassia sieberiana DC on mice,” J. Intercult. Ethnopharmacol., vol. 4, no. 2, p. 96, 2015.

R. E. Phillips, D. A. Warrell, N. J. White, S. Looareesuwan, and J. Karbwang, “Intravenous quinidine for the treatment of severe falciparum malaria: clinical and pharmacokinetic studies,” N. Engl. J. Med., vol. 312, no. 20, pp. 1273–1278, 1985.

A. Haidet, “The medicinal value of the rainforest,” Final Pap. Trop. F. courses Submitt. to Dep. Interdiscip. Stud. Miami Univ. USA, 2003.

A. A. Jigam, H. O. Akanya, and D. J. Adeyemi, “Antimicrobial and antiplasmodial effects of Momordica balsamina,” Niger. J. Nat. Prod. Med., vol. 8, no. 1, pp. 11–12, 2004.

A. D. Fall et al., “Anticoccidian activity of ethanol roots extract of Cassia sieberiana DC in chickens,” Eur. J Med Plants, vol. 11, pp. 1–7, 2016.

J. Kerharo and L. G. Adam, “Traditional Senegalese pharmacopoeia,” Med. poisonous plants. Ed Vigot Brother. Paris, 1974.

W. Diatta et al., “Popular traditional herbal medicines from the Jóolas of Essyl in the rural community of Enampor (Ziguinchor, Sénégal): An ethnographic survey,” in ACS symposium series, 2009, vol. 1021, pp. 111–133.

A. D. Dossou, O. B. Gbati, N. Ayessou, S. B. Ayssiwede, and A. Missohou, “Effets du tourteau de Neem (Azadirachta indica) sur les coccidioses aviaires,” Rev. Afr Santé Prod Anim, vol. 7, pp. 15–20, 2009.

D. P. Anton R., “The use of cassia in tropical and subtropical countries examined under a few chemical constituents of these medicinal plants.,” Med Plants. Phytother., vol. 12, no. 4, pp. 225–268, 1968.

R. Paris and S. Etchepare, “On the polyphenols of Cassia sieberiana DC. Isolation of l-epicatechol and leucopelargonidol,” in Annales pharmaceutiques francaises, 1967, vol. 25, no. 5, pp. 343–346.

M. Wink, “Medicinal plants: a source of anti-parasitic secondary metabolites,” Molecules, vol. 17, no. 11, pp. 12771–12791, 2012.

G. D. Kolovou, K. K. Anagnostopoulou, K. D. Salpea, and D. P. Mikhailidis, “The prevalence of metabolic syndrome in various populations,” Am. J. Med. Sci., vol. 333, no. 6, pp. 362–371, 2007.

P. C. Nweje-Anyalowu, M.-M. Agatemor Uzuazokaro, Idakwoji Precious Adejoh, and L. O. Iserhienrhien, “Protective Effects of Methanolic Extract of Cassia Sieberena Leaves Against High-Fat Diet-Induced Metabolic Syndrome in Rats,” World J. Pharm. Life Sci., vol. 4, no. September, pp. 41–47, 2018.

O. O.B., “Carbohydrates ‘All for the love of nutrients.,’” Seventy-Eight Inaug. Lect. Univ. Ilorin, vol. 14, no. 31, 2005.

S. Gorinstein et al., “Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans,” J. Agric. Food Chem., vol. 54, no. 5, pp. 1887–1892, 2006.

E. B. Oyewo and M. A. Akanji, “Immune modulation potentials of aqueous extract of Andrographis paniculata leaves in male rat,” Researcher, vol. 3, no. 1, pp. 48–57, 2011.

M. D. Tracey Kevin J and P. D. Cerami Anthony, “Tumor necrosis factor: A pleiotropic cytokine and therapuetic target,” Annu. Rev. Med., vol. 45, no. 1, pp. 491–503, 1994.

S. C. Renaud, R. Guéguen, G. Siest, and R. Salamon, “Wine, beer, and mortality in middle-aged men from eastern France,” Arch. Intern. Med., vol. 159, no. 16, pp. 1865–1870, 1999.

N. D. Turner et al., “Grapefruit and its isolated bioactive compounds act as colon cancer chemoprotectants in rats,” in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, vol. 228, pp. U70–U71.

J. E. Gerich, “Physiology of glucose homeostasis,” Diabetes, Obes. Metab., vol. 2, no. 6, pp. 345–350, 2000.

W. Obidah, U. A. Sarsquo, and A. U. Wurochekke, “Toxic effects of aqueous stem bark extract of Cassia sieberiana on some biochemical parameters in rats,” African J. Biochem. Res., vol. 3, no. 5, pp. 229–231, 2009.

K. Donkor, L. N. K. Okine, W. K. M. Abotsi, and E. Woode, “Acute and Sub-Chronic Toxicity Studies of aqueous extract of root bark of Cassia sieberiana DC in Rodents,” J. Appl. Pharm. Sci., vol. 4, no. 4, pp. 084–089, 2014.

O. A. E. Ajayi, Clement Olusoji, Elujoba, Anthony A., Beijide, Ronald A., Akinloye Johnson A., “Toxicity and Pharmacognostic Standards for Laxative Properties of Nigerian Cassia sieberiana and Senna obtusifolia Roots,” European J. Med. Plants, vol. 6, no. 2, pp. 110–123, 2015.

F. Bah et al., “Acute , Sub-Chronic Toxicity in Wistar Rats and Cytotoxicity Studies of Hydroethanolic Root Extract of Cassia Sieberiana DC,” J. Toxicol. Pharmacol. Res., vol. 1, no. 3, pp. 1–5, 2017.

H. H. Tamboura, B. Bayala, M. Lompo, I. P. Guissoe, and L. Sawadogo, “Ecological Distribution, Morphological Characteristics and Acute Toxicity Of Aqueous Extracts Of Holarrhena Floribunda (G. Don) Durand & Schinz, Leptadenia Hastata (Pers.) Decne And Cassia Sieberiana (Dc) Used By Veterinary Healers In Burkina Faso.,” African J. Tradit. Complement. Altern. Med., vol. 2, no. 1, pp. 13–24, 2005.

Y. and B. L. B. (2014) Khala, H. M., Karumi, “Studies on the hepatotoxic effects of Cassia sieberiana DC stem bark aqueous extract in rats. Academia,” J. Med. Plants 2(3), 049-056., vol. 2, no. 3, pp. 49–56, 2014.

A. A. Biu, L. B. Buratai, M. Konto, J. Luka, and M. M. Hauwa, “Acute toxicity study on aqueous extract of the leaf of Cassia sieberiana DC (Caesalpiniaceae) in albino rats,” 2013.




How to Cite

Archer, M.-A. ., Asafo Agyei, T. ., Oteng Mintah, S. ., Atta-Adjei Junior, P. ., Kumadoh, D. ., & Asiedu-Larbi, J. . (2019). Medicinal Uses of Cassia Sieberiana; A Review. International Journal of Sciences: Basic and Applied Research (IJSBAR), 48(2), 161–180. Retrieved from