Literature Review: Role of Fibrinogen in Operations
Keywords:
Fibrinogen, OperationsAbstract
Fibrinogen, a plasma glycoprotein synthesized in the liver, plays a central role in hemostasis, primarily as a precursor to fibrin, a key structural protein in clot formation. Its importance is particularly highlighted in surgical settings where bleeding risks are elevated. Hypofibrinogenemia is a situation where the total fibrinogen level is very low, and its effects include an increased risk of hemorrhagic events, long surgical operations, and an increase in the frequency of blood product transfusions. Literature review will focus on the function of fibrinogen, its importance during surgery, and its treatment through the administration of fibrinogen derivatives. The findings of the study also support previous insights into the functionality of fibrinogen in coagulation and suggest the importance of early action when fibrinogen levels have been depleted during a major hemorrhage. Fibrinogen concentrate and cryoprecipitate are common supplementation strategies, but barriers such as cost, availability, and lack of standardized thresholds limit their widespread application.
References
J. J. Yang et al., “Preoperative Serum Fibrinogen is Associated With Acute Kidney Injury after Cardiac Valve Replacement Surgery,” Scientific Reports, vol. 10, no. 1, Apr. 2020, doi: https://doi.org/10.1038/s41598-020-63522-6.
M. Ranucci, E. Baryshnikova, G. B. Crapelli, N. Rahe?Meyer, L. Menicanti, and Alessandro Frigiola, “Randomized, Double?Blinded, Placebo?Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery,” Journal of the American Heart Association, vol. 4, no. 6, Jun. 2019, doi: https://doi.org/10.1161/jaha.115.002066.
T. Lissitchkov et al., “Fibrinogen concentrate for treatment of bleeding and surgical prophylaxis in congenital fibrinogen deficiency patients,” Journal of Thrombosis and Haemostasis, vol. 18, no. 4, pp. 815–824, Apr. 2020, doi: https://doi.org/10.1111/jth.14727.
R. Marchi et al., “Fibrin clot properties to assess the bleeding phenotype in unrelated patients with hypodysfibrinogenemia due to novel fibrinogen mutations,” Thrombosis Research, vol. 197, pp. 56–64, Jan. 2021, doi: https://doi.org/10.1016/j.thromres.2020.11.003.
R. Mai, T. Bai, X. Luo, and G. Wu, “Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with hepatocellular carcinoma subjected to hepatectomy,” BMC Gastroenterology, vol. 22, no. 1, May 2022, doi: https://doi.org/10.1186/s12876-022-02328-4.
N. B. Hensley and M. A. Mazzeffi, “Pro-Con Debate: Fibrinogen Concentrate or Cryoprecipitate for Treatment of Acquired Hypofibrinogenemia in Cardiac Surgical Patients,” Anesthesia & Analgesia, vol. 133, no. 1, pp. 19–28, Jun. 2021, doi: https://doi.org/10.1213/ane.0000000000005513.
A. Casini, M. Neerman-Arbez, and P. de Moerloose, “Heterogeneity of congenital afibrinogenemia, from epidemiology to clinical consequences and management,” Blood Reviews, vol. 48, p. 100793, Jul. 2021, doi: https://doi.org/10.1016/j.blre.2020.100793.
M. Gomes, M. Ângelo-Dias, G. S. Duarte, S. S. Dias, S. S. Serra, and J. Lima, “Safety of Fibrinogen Concentrate in Non-Trauma and Non-Obstetric Adult Patients during Perioperative Care: Systematic Review and Meta-Analysis,” Journal of Clinical Medicine, vol. 13, no. 12, pp. 3482–3482, Jun. 2024, doi: https://doi.org/10.3390/jcm13123482.
L. Abrahamyan et al., “Cost-effectiveness of Fibrinogen Concentrate vs Cryoprecipitate for Treating Acquired Hypofibrinogenemia in Bleeding Adult Cardiac Surgical Patients,” JAMA Surgery, Jan. 2023, doi: https://doi.org/10.1001/jamasurg.2022.6818.
O. Grottke, S. Mallaiah, K. Karkouti, F. Saner, and T. Haas, “Fibrinogen Supplementation and Its Indications,” Seminars in Thrombosis and Hemostasis, vol. 46, no. 01, pp. 038–049, Oct. 2019, doi: https://doi.org/10.1055/s-0039-1696946.
A. Honarmand, K. Bagheri, Alireza Hoghooghy, and K. Rezaei, “Evaluation of plasma fibrinogen levels before and after coronary artery bypass graft surgery and its association with the need for blood products,” Advanced Biomedical Research, vol. 11, no. 1, pp. 25–25, Jan. 2022, doi: https://doi.org/10.4103/abr.abr_22_21.
M. Postl et al., “The Predictive Value of the Fibrinogen–Albumin-Ratio Index on Surgical Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer,” Cancers, vol. 16, no. 19, pp. 3295–3295, Sep. 2024, doi: https://doi.org/10.3390/cancers16193295.
X. Cao, J. Cui, T. Yu, Z. Li, and G. Zhao, “Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors,” Frontiers in Oncology, vol. 10, Aug. 2020, doi: https://doi.org/10.3389/fonc.2020.01459.
A. Daud et al., “Fibrin and Thrombin Sealants in Vascular and Cardiac Surgery: A Systematic Review and Meta-analysis,” European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery, vol. 60, no. 3, pp. 469–478, Sep. 2020, doi: https://doi.org/10.1016/j.ejvs.2020.05.016.
H. Charbonneau, M. Pasquie, and N. Mayeur, “Preoperative plasma fibrinogen level and transfusion in cardiac surgery: a biphasic correlation,” Interactive CardioVascular and Thoracic Surgery, vol. 31, no. 5, pp. 622–625, Sep. 2020, doi: https://doi.org/10.1093/icvts/ivaa153.
P. Fricault et al., “Preoperative fibrinogen level and postcardiac surgery morbidity and mortality rates,” Annals of Cardiac Anaesthesia, vol. 25, no. 4, pp. 485–489, Oct. 2022, doi: https://doi.org/10.4103/aca.aca_103_21.
N. Dennhardt et al., “Prevention of postoperative bleeding after complex pediatric cardiac surgery by early administration of fibrinogen, prothrombin complex and platelets: a prospective observational study,” BMC Anesthesiology, vol. 20, no. 1, Dec. 2020, doi: https://doi.org/10.1186/s12871-020-01217-1.
G. Dumitrescu et al., “Fibrinogen and albumin synthesis rates in major upper abdominal surgery,” PLoS ONE, vol. 17, no. 10, pp. e0276775–e0276775, Oct. 2022, doi: https://doi.org/10.1371/journal.pone.0276775.
E. A. Vlot et al., “Association of Plasma Fibrinogen and Thromboelastography With Blood Loss in Complex Cardiac Surgery,” Clinical and Applied Thrombosis/Hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, vol. 27, p. 10760296211016541, 2021, doi: https://doi.org/10.1177/10760296211016541.
V. Iki?, “Fibrinogen and Bleeding in Adult Cardiac Surgery: A Review of the Literature,” Surgeries, vol. 2, no. 4, pp. 409–436, Nov. 2021, doi: https://doi.org/10.3390/surgeries2040041.
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