Influence of Zinc and Molybdenum Contents in Soil and Drinking Water for the Development of Esophageal Cancer: A Cross Continental Study

S. S. Ray, D. Das, T. Ghosh, S. S. Ray, A. K. Ghosh


There are several endemic areas (hot spot) of esophageal cancer (EC) around the world and the geochemical structure of that area has a vital role for the endemicity. Different elements in soil are lixiviated in water which is the major source of different elements needed for the living system. Thus, the elemental status of soil and drinking water of a particular area influences the elemental status ofliving system. In human system, the deficiencies of Zn and Mo have got an important role for the development of esophageal cancer. So, Zn and Mo contents of soil and drinking water of an endemic area of esophageal cancer may be related to the development of deficiencies of these elements in human system.

In the present investigation, a comparative evaluation of Zn and Mo contents in soil and drinking water of a hot spot and a cold spot of EC was carried out. The samples of soil and drinking water (underground water) were taken from Eastern Cape, South Africa (RSA) (a hot spot) and West Bengal, India (INDIA) (a cold spot). The soil and drinking water were analyzed for Zn and Mo contents using Atomic Absorption Spectrophotometer (AAS). The results showed that both soil and drinking water of Eastern Cape, South Africa was significantly deficient in Zn and Mo contents as compared to West Bengal, India. Apart from other environmental risk factors the deficiencies of Zn and Mo in both soil and drinking water of Eastern Cape, South Africa are the major contributors for the development of an endemic area of esophageal cancer.



Esophageal Cancer; Trace elements; Zinc; Molybdenum; Soil; Water; Eastern Cape; South Africa; West Bengal; India.


P. M. Sagar. (1989) “Aetiology of cancer of the oesophagus: geographical studies in the footsteps of Marco Polo and beyond.” Gut, vol. 30, pp. 561–4, 1989. doi:10.1136/gut.30.5.561.

N. I. M. Somdyala, D. Bradshaw, B. Curtis, W. C. A. Gelderblom. “Cancer incidence in selected municipalities of the Eastern Cape Province,” in PROMEC Cancer Registry Technical Report 1998-2002. South African Medical Research Council, Cape Town, 2007.

N. Mqoqi, P. Kellet, F. Sitas, M. Jula. “Incidence of histologically diagnosed cancer in South Africa, 1998-1999. National Cancer Registry of South Africa. Johannesburg: National Health Laboratory Service, 2004.

Indian Council of Medical Research, New Delhi, India “National Cancer Registry.” 2000.

D. L. Shu. “Drinking water and liver cancer.” J Chin Prev, vol. 14, pp. 65–73, 1980.

N. F. Lin.Medical Environmental Geochemistry. Changchun City of China: Jilin Science and Technology Publishing House, 1991, pp. 125–256.

J. Tang. Study on Medical Geography in China: Formulation of Local Standards and Comprehensive Evaluation of Water Quality in Epidemic Areas of Jiashi Disease in Xinjiang. Beijing: China Medico-Pharmaceutical Science and Technology Publishing, 1994, pp. 225–231.

N.F. Lin, J. Tang, J. M. Bian (2004) “Geochemical environment and health problems in China.” Environ Geochem Health, vol. 26, pp. 81–88, 2004. doi:10.1023/B:EGAH.0000020987.74065.1d.

W. O. Mwanda, J. Orem, S. C. Remick, et al. (2005) “Clinical characteristics of Burkitt's lymphoma from three regions in Kenya.” East Afr Med, vol. 82, pp. 135-43, 2005.

O. Selinus, J. Centeno, R. Finkelman., R. Fuge., U. Lindh, P. Smedley.Essentials of medical geology: impacts of the natural environment on public health. Amsterdam: Elsevier Academic Press, 2005, pp.1-14.

J. A. Centeno, R. B. Finkelman, O. Selinus (2016) “Medical Geology: Impacts of the Natural Environment on Public Health.” Geosciences, vol. 6, pp. 8. doi:10.3390/geosciences6010008.

J. E. Bunnell. "Medical Geology: Emerging Discipline on the Ecosystem–Human Health Interface." EcoHealth, vol. 1, pp. 15-18, 2004.

O. Selinus. “Medical geology: An emerging speciality.” Terrae, vol. 1, pp. A1–A8, 2004.

C. A. Bowman, P. T. Bobrowsky, O. Selinus. “Medical geology: New relevance in the earth sciences.” Episodes, vol. 26, pp. 270–277, 2003.

O Selinus. “Medical geology. Method, theory and practice,” in Geoenvironmental mapping, : P. T. Bobrowsky, Ed. Rotterdam: Balkema Press, 2002.

R. B. Finkelman, H. C. W. Skinner, G. S. Plumlee, J. E. Bunnell. “Medical geology.” Geotimes, vol. 46, pp. 20–23, 2001.

J. P. Rheeder, W. F. Marasas, M. P. Farina, G. R. Thompson, P. E. Nelson. “Soil fertility factors in relation to oesophageal cancer risk areas in Transkei, southern Africa.” Eur J Cancer Prev, vol. 3, pp. 49-56, 1994.

J. D. Appleton, Q. Zhang, K. A. Green, G. Zhang, X. Ge, X. Liu, J. X. Li “Selenium in soil, grain, human hair and drinking water in relation to oesophageal cancer in the Cixian area, Hebei Province, People’s Republic of China”. Applied Geochemistry 21(4): 684-700, 2006.

S. Semnani, G. Roshandel, A. Zendehbad, A. Keshtkar, H. Rahimzadeh, N. Abdolahi, S. Besharat, A. Moradi, H. Mirkarimi, S. Hasheminasab. “Soils selenium level and esophageal cancer: An ecological study in a high risk area for esophageal cancer.” Journal of Trace Elements in Medicine and Biology, vol. 24, pp. 174–177, 2010.

B. Keshavarzi, F. Moore, A. Najmeddin, F. Rahmani, A. Malekzadeh “Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link.” Environ Geochem Health, vol. 34, pp. 15-26, 2012. doi: 10.1007/s10653-011-9377-3.

M. H. Mellow, E. A. Layne, T. O. Lipman, M. Kaushik, C. Hostetler, J. C. Smith. Jr. “Plasma zinc and vitamin A in human squamous carcinoma of the esophagus.” Cancer, vol. 51, pp. 1615–20, 1983.

D. H. Barch, P. M. Iannaccone. “Role of zinc deficiency in carcinogenesis”. AdvExp Med Biol, vol. 206, pp. 517–27, 1986.

C. S. Yang. “Research on esophageal cancer in china: a review.” Cancer Res, vol. 40, pp. 2633-44, 1980.

M. A. Rogers, D. B. Thomas, S. Davis, T. L. Vaughan, A. E. Nevissi “A case-control study of elements levels and cancer of the upper aerodigistive tract cancer.” Epidemiol Biomarkers Prev, vol. 2, pp. 305–12, 1993.

X. Luo, H. J. Wei, G. Hu, A. L. Shang, Y. Y. Liu, S. M. Lu. “Molybdenum and Esophageal Cancer in China.” Fed Proc, vol. 46, 1981.

J. Chen, C. Geissler, B. Parpia, J. Li, T. C. Campbell. “Antioxidant status and cancer mortality in China” Int. J. Epidemiol, vol. 21, pp. 625–635, 1992. doi: 10.1093/ije/21.4.625.

K. Jaskiewicz, W. F. Marasas, J. E. Rossouw, F. E. Van Niekerk, E. W. Heine Tech. “Selenium and other mineral elements in populations at risk for esophageal cancer.” Cancer, vol. 62, pp. 2635–2639, 1988.

S. S. Ray, D. Das, T. Ghosh, and A. K. Ghosh (2012) “The levels of zinc and molybdenum in hair and food grain in areas of high and low incidence of esophageal cancer: a comparative study.” Glob J Health Sci, vol. 4, pp. 168-75, 2012. doi: 10.5539/gjhs.v4n4p168.

American public health association, "Standard methods for the examination of water and wastewater", 20th ed. Washington, D.C., 1998.

M. G. Kibblewhite, S. J. van Rensburg, M. C. Laker, E. F. Rose. “Evidence for an intimate geochemical factor in the etiology of esophageal cancer.” Environ Res, vol. 33, pp. 370 – 378, 1984. doi:10.1016/0013-9351(84)90035-5.

Gerald, F., Combs (2005) Geological Impacts on Nutrition. In: O. Selinus, B. Alloway, J.A. Centeno, R.B Finkelman, R. Fuge, U. Lindh and P. Smedley (Eds.) Essentials of Medical Geology: Impacts of the Natural Environment on Public Health, Elsevier, London, Paris, p 161-178.

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