@article{Lidya Mamonto_Muh. Husni Cangara_Ni Ketut Sungowati_Upik A Miskad_Juniarsih Tande Padang_Andi Alfian Zainuddin_2022, title={The Relationship of CXC Chemokine Receptor 4 (CXCR4) Expression with Histopathological Grading of Invasive Breast Cancer}, volume={64}, url={https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14555}, abstractNote={<p><strong>Introduction:</strong> The histological grade of the tumor influences the prognosis of breast cancer. In metastatic breast cancer, the stromal cells produce a chemokine (C-X-C motif chemokine 12/CXCL12) or the so-called stromal-derived factor-1 (SDF-1) as a chemoattractant, which binds to the chemokine receptor (C-X-C chemokine receptor type 4/CXCR4) which is expressed by breast cancer cells. This study aimed to determine the expression of CXCR4 in invasive breast cancer associated with histopathological grading of invasive breast cancer.</p> <p><strong>Methods:</strong> This study is observational with a retrospective approach using a paraffin block archive sample diagnosed with Invasive Breast Cancer. Immunohistochemical staining using CXCR4 antibody and expression analysis was performed by light microscopy. The data were statistically analyzed by the Chi-Square test and presented in the table. The statistical test results were significant if the p-value was <0.05.</p> <p><strong>Results:</strong> Showed no significant relationship between CXCR4 expression and histopathological grading in invasive breast cancer with a p-value = 0.467.</p> <p><strong>Conclusion:</strong> The data of this study showed that the expression of CXCR4 in Invasive Breast Cancer varied and did not support its role in determining histopathological grading.</p>}, number={1}, journal={International Journal of Sciences: Basic and Applied Research (IJSBAR)}, author={Lidya Mamonto and Muh. Husni Cangara and Ni Ketut Sungowati and Upik A Miskad and Juniarsih Tande Padang and Andi Alfian Zainuddin}, year={2022}, month={Sep.}, pages={41–49} }