The Relationship of CXC Chemokine Receptor 4 (CXCR4) Expression with Histopathological Grading of Invasive Breast Cancer

Authors

  • Lidya Mamonto Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Muh. Husni Cangara Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Ni Ketut Sungowati Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Upik A Miskad Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Juniarsih Tande Padang Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Andi Alfian Zainuddin Department of Public Health and Community Medicine Science, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Keywords:

CXCR4, Invasive Breast Cancer, histopathological grading

Abstract

Introduction: The histological grade of the tumor influences the prognosis of breast cancer. In metastatic breast cancer, the stromal cells produce a chemokine (C-X-C motif chemokine 12/CXCL12) or the so-called stromal-derived factor-1 (SDF-1) as a chemoattractant, which binds to the chemokine receptor (C-X-C chemokine receptor type 4/CXCR4) which is expressed by breast cancer cells. This study aimed to determine the expression of CXCR4 in invasive breast cancer associated with histopathological grading of invasive breast cancer.

Methods: This study is observational with a retrospective approach using a paraffin block archive sample diagnosed with Invasive Breast Cancer. Immunohistochemical staining using CXCR4 antibody and expression analysis was performed by light microscopy. The data were statistically analyzed by the Chi-Square test and presented in the table. The statistical test results were significant if the p-value was <0.05.

Results: Showed no significant relationship between CXCR4 expression and histopathological grading in invasive breast cancer with a p-value = 0.467.

Conclusion: The data of this study showed that the expression of CXCR4 in Invasive Breast Cancer varied and did not support its role in determining histopathological grading.

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Published

2022-09-23

How to Cite

Lidya Mamonto, Muh. Husni Cangara, Ni Ketut Sungowati, Upik A Miskad, Juniarsih Tande Padang, & Andi Alfian Zainuddin. (2022). The Relationship of CXC Chemokine Receptor 4 (CXCR4) Expression with Histopathological Grading of Invasive Breast Cancer. International Journal of Sciences: Basic and Applied Research (IJSBAR), 64(1), 41–49. Retrieved from https://gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14555

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Vol. 64 No. 1 (2022)

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