Correlation Between Histopathological Grading and Appearance of Obstruction With Level of Carsino-Embryonic Antigen (CEA) in Colorectal Carcinoma

Taufiq Ardianto, Warsinggih Warsinggih, Arifin Seweng

Abstract


CEA (Carcinoembryonic Antigen) is a blood colorectal tumor marker test that widely used in a clinical setting. The aim of this research is to assess the correlation between carcinoembryonic antigen (CEA) and the degree of tumor differentiation, and between obstruction and age of patients and colorectal adenocarcinoma. This research was a retrospective analytic observational study with a cross-sectional approach. This research used medical record of colorectal carcinoma patients without other malignancy obtained from Wahidin Sudirohusodo Hospital having complete medical records from 2015 to 2017. Initial anamnesis, the result of radiology, laboratory, and the result of pathology were obtained and analyzed using univariate and bivariate analyses with the value of CEA cutoff 5ng/ml. The result of 107 samples, most of the subjects examined is female (60.7%), between the ages of 41-60 years (48.6%) with the levels of CEA >= 5 (55.1%). Histopathology examination results showed most of the differentiate were moderate (68.2%). While the obstruction was found in 34 subjects (31.8%). We found a significant relationship between the presence of an obstruction with levels of CEA (p < 0.001), and degree of differentiating with the CEA levels also showed a significant relationship (p < 0.001). The result of the analysis indicates that there is a significant correlation between CEA level and the degree of differentiation and obstruction. Obstruction has a more significant correlation with high CEA level. There is no significant correlation between age group and CEA level.


Keywords


Carcinoembryonic antigen; colorectal adenocarcinoma; obstruction; the degree of differentiation; age.

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References


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