Delivery of Analeptics via Painless Transdermal Patches

Fazeeha Amjad, Kainaat Fareed, Zainab Rafique, Faryal Arshad, Mubeen Dilawar, Nawal Arooj, Romasa Naz, Pervez Anwar


Putting into service a preliminary transdermal patch on the skin, an appropriate dosage of drug can be delivered to the site of therapeutic effect within the body. This supreme delivery system is painless and more efficacious. These patches are designed by adhering analeptic compounds over them. In conjugation to these therapeutic compounds essential oils having anti-inflammatory, anticancer, antioxidant and healing properties are also used, increasing the durability of drug. Natural and synthetic polymers comprising cellulose derivatives and polyvinyl chloride respectively are significant in their designing. There are assorted categories of transdermal drugs, depending on the layers of therapeutic compounds, inclusive of single layer, bi-layer, multilayer, matrix and reservoir. Transdermal delivery has its own wondrous aptness. It enhances bioavailability of drugs eliminating the first pass effect in gastrointestinal tract. It is efficient in treating not only extraneous skin infection, but it also holds a strong curable impact on internal disorders extending from hormonal imbalance to either neurodegenerative diseases or cardiovascular diseases. Nicotine patches are prodigiously practiced treating nicotine addicts.  


Drug delivery; transdermal patches; types of transdermal drugs; applications of TDD.

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H. Marwah, T. Garg, A. K. Goyal, and G. Rath, "Permeation enhancer strategies in transdermal drug delivery," Drug delivery, vol. 23, pp. 564-578, 2016.

K. Priyanka, R. Pentewar, O. Bhusnure, S. Thonte, M. Supriya, and R. Sarda, "USE OF NOVEL PENETRATION ENHANCERS AND TECHNIQUES IN TDDS," American Journal of Pharmaceutical Research, vol. 5, 2015.

A. Herman and A. P. Herman, "Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review," Journal of Pharmacy and Pharmacology, vol. 67, pp. 473-485, 2015.

E. Zecca, A. Manzoni, F. Centurioni, A. Farina, E. Bonizzoni, D. Seiler, et al., "Pharmacokinetic study between a bilayer matrix fentalyl patch and a monolayer matrix fentanyl patch: single dose administration in healthy volunteers," British journal of clinical pharmacology, vol. 80, pp. 110-115, 2015.

K. Mojsiewicz-Pieńkowska, M. Jamrógiewicz, M. Żebrowska, B. Mikolaszek, and M. Sznitowska, "Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment," International journal of pharmaceutics, vol. 481, pp. 18-26, 2015.

O. Kerımoğlu, S. Şahbaz, Ö. Şehırlı, Z. Ozdemır, Ş. Çetınel, B. Dortunc, et al., "PHARMACODYNAMICAL EVALUATION OF MATRIX TYPE TRANSDERMAL THERAPEUTIC SYSTEMS CONTAINING CAPTOPRIL," Acta poloniae pharmaceutica, vol. 72, pp. 799-806, 2014.

S. Jeon, C. Y. Yoo, and S. N. Park, "Improved stability and skin permeability of sodium hyaluronate-chitosan multilayered liposomes by Layer-by-Layer electrostatic deposition for quercetin delivery," Colloids and Surfaces B: Biointerfaces, vol. 129, pp. 7-14, 2015.

R. Parhi, P. Suresh, and S. Patnaik, "Application of Response Surface Methodology for Design and Optimization of Reservoir-type Transdermal Patch of Simvastatin," Current drug delivery, vol. 13, pp. 742-753, 2016.

X. Zhan, Z. Mao, S. Chen, S. Chen, and L. Wang, "Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate," Brazilian Journal of Pharmaceutical Sciences, vol. 51, pp. 373-382, 2015.

C. Durand, A. Alhammad, and K. C. Willett, "Practical considerations for optimal transdermal drug delivery," American Journal of Health-System Pharmacy, vol. 69, 2012.

S. Premjeet, A. Bilandi, K. Sahil, and M. Akanksha, "Transdermal drug delivery system (patches), Application in present scenario," International Journal of Research in Pharmacy and Chemistry, vol. 1, pp. 1139-1151, 2011.

A. C. Krakowski, S. Stendardo, and L. F. Eichenfield, "Practical considerations in acne treatment and the clinical impact of topical combination therapy," Pediatric dermatology, vol. 25, pp. 1-14, 2008.

J. Yu, K. Wan, and X. Sun, "Improved transdermal delivery of morin efficiently inhibits allergic contact dermatitis," International Journal of Pharmaceutics, 2017.

P. González-Vázquez, E. Larrañeta, M. T. McCrudden, C. Jarrahian, A. Rein-Weston, M. Quintanar-Solares, et al., "Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis," Journal of Controlled Release, 2017.

J. R. Stevens, M. J. Coffey, M. Fojtik, K. Kurtz, and T. A. Stern, "The use of transdermal therapeutic systems in psychiatric care: a primer on patches," Psychosomatics, vol. 56, pp. 423-444, 2015.

D. Ameen and B. Michniak-Kohn, "Transdermal delivery of dimethyl fumarate for Alzheimer’s disease: Effect of penetration enhancers," International Journal of Pharmaceutics, 2017.

M. B. Delgado-Charro and R. H. Guy, "Effective use of transdermal drug delivery in children," Advanced drug delivery reviews, vol. 73, pp. 63-82, 2014.

W. Yu, G. Jiang, D. Liu, L. Li, Z. Tong, J. Yao, et al., "Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite," Materials Science and Engineering: C, vol. 73, pp. 425-428, 2017.

W. Yu, G. Jiang, D. Liu, L. Li, H. Chen, Y. Liu, et al., "Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin," Materials Science and Engineering: C, vol. 71, pp. 725-734, 2017.

J. Hadgraft and M. E. Lane, "Transdermal delivery of testosterone," European Journal of Pharmaceutics and Biopharmaceutics, vol. 92, pp. 42-48, 2015.

R. M. Galzote, S. Rafie, R. Teal, and S. K. Mody, "Transdermal delivery of combined hormonal contraception: a review of the current literature," International journal of women's health, vol. 9, p. 315, 2017.

Y.-L. Lin, C.-H. Chen, H.-Y. Wu, N.-M. Tsai, T.-Y. Jian, Y.-C. Chang, et al., "Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex," Journal of nanobiotechnology, vol. 14, p. 11, 2016.

P. Bezwada, A. Shaikh, and D. Misra, "The Effect of Transdermal Estrogen Patch Use on Cardiovascular Outcomes: A Systematic Review," Journal of Women's Health.

S. Güngör and Y. Özsoy, "Systemic delivery of antihypertensive drugs via skin," Therapeutic delivery, vol. 3, pp. 1101-1116, 2012.

J. M. Ramon, S. Morchon, A. Baena, and C. Masuet-Aumatell, "Combining varenicline and nicotine patches: a randomized controlled trial study in smoking cessation," BMC medicine, vol. 12, p. 172, 2014.

P. Chauhan, A. Dev, S. Desai, and V. Andhale, "Nicotine replacement therapy for smoking cessation," Pharmaceutical and Biological Evaluations, vol. 3, pp. 305-312, 2016.


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