Seroprevalence of Toxoplasma gondii Infection in Diabetic Patients at Kirkuk province

Sarah Farhad Nihad, Sadia Shahab Hamad

Abstract


Toxoplasma gondii is an important opportunistic parasite in immunocompromised people .On other hand , diabetes is the disease affecting in immune system and minimizes cellular and humoral immunity. Both toxoplasmosis and diabetes are very common in Iraq and other countries. The main aim of the current study was investigated the seroprevalence of anti-Toxoplasma gondii antibodies IgG and IgM in the blood of diabetic patients attending Azadi Teaching Hospital, Kirkuk General Hospital within Kirkuk province for the period of January 2016-February 2017 , with a group of non diabetic patients to serve as a control group . The Enzyme Linked Immuno Sorbent Assay ( ELISA) technique was implemented to detect the antibodies for Toxoplasma gondii in the sera of 100 patient with diabetic and 45 non diabetic apparently healthy control. A total of 100 sample obtained from diabetic patients (44 male and 54 female with age range (20-60 years) were examined for the presence of toxoplasma antibodies the results showed , 31 cases (31%) were positive included 10%  for IgM and 21% for IgG , None of the apparently healthy controls showed seopositivity for T. gondii IgM antibodies but seopositivity for T. gondii IgG antibodies were in 5 cases(11.11 %). The relationship between diabetes and T. gondii was evaluated using chi-square test ( P< 0.05) and ( P< 0.01).  As long as the diabetes lowers the immune response, it may pave the way to toxoplasmosis so our hypothesis is that toxoplasmosis paves the way for diabetes and diabetes paves the way for diabetes but this depends on which one establishes first.


Keywords


Toxoplasma gondii ; Diabetes Mellitus; ELISA.

Full Text:

PDF

References


. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet.2004; 363 ]9425 [:1965-1976.

. Jones JL, Dubey JP. Foodborne toxoplasmosis. Clin Infect Dis. 2012;55]6[:845-851.

. Saadatnia G, Golkar M. A review on human toxoplasmosis.Scand J Infect Dis. 2012;44] 11[:805-814.

. Pradhan S, Yadav R, Mishra VN. Toxoplasma meningoencephalitis in HIV seronegative patients: clinical patterns,imaging features and treatment outcome. Trans R Soc Trop Med Hyg. 2007;101]1[:25-33.

. Harker KS, Ueno N, Lodoen MB. Toxoplasma gondii dissemination:a parasite's journey through the infected host.Parasite Immunol. 2015;37]3[:141-149.

. Hofman P, Michiels JF, Mondain V, Saint-Paul MC, Rampal A, Loubiere R. [Acute toxoplasmic pancreatitis. An unusual cause of death in AIDS. Gastroenterol Clin Biol. 1994;18]10[:895-897.

. J P. Dubey ., O. Hedstrom , R. Craig, G. Machado and O . Kent. Journal of Zoo and Wildlife Medicine ., 1991, 22]3[ , 348-350.

. Y. Sukthana , P. Waaree , E. Pongponratn , U . Chaisri , M. Riganti. Southeast Asian J. Trop Med Public Health. 2003; 34] 1[ : 16-21.

. DG. Mordue, F . Monroy , ML. Regina, CA. Dinarello, LD. Sibley. Acute Toxoplasmosis lead to leathal over J. production of Th1 cytokines Immunol , 2001, 74: 45-84.

. Sharad, N.A. and AL-Hamairy, A.K. Seroepidemiological study for patients with diabetes that infected with Toxoplasma gondii in the Babylon province. International Journal of Innovation and Applied Studies, 2015; 12: 183-189.

. A. Karadag , O. Erdeve , B. Atasay , S .Arsan , G.Deda , E. Ince , O. G cal , M. Berberoglu . J Pediatr Endocrinol Metab .2006 ; 19] 2[ :173-5.

. Siyadatpanah, A., Tabatabaie, F., Oormazdi, H., Reza, A., Meamar, E.R., Hadighi, R., et al. Comparison of anti-toxoplasma IgG and IgM antibodies determined by ELISA method in diabetic and non-diabetic individuals in west Mazandaran province, Iran, 2011-2012. Annals of Biological Research Journal, 2013; 4] 6[: 281-285.

. IDF Diabetes. International diabetes federation. Lancet, 2014; 200: 143-150.

. Wilson M, Remington JS, Clavet C, Varney G, Press C, Ware D. Evaluation of six commercial kits for detection of human immunoglobulin M antibodies to Toxoplasma gondii. The FDA Toxoplasmosis Ad Hoc Working Group. J Clin Microbiol. 1997;35] 12 [:3112-5.

. Oz, H.S. Toxoplasmosis, Pancreatitis, Obesity and Drug Discovery. Pancreatic Disorders and Therapy, 2014; 4]2[: 138.

. Modrek, M.J., Saravani, R., Mousavi, M., Khorashad, A.S. and Piri, M. Investigation of IgG and IgM antibodies against Toxoplasma gondii among diabetic patients. International Journal of Infection, 2015; 2]3[: 1-5.

. Sharad, N.A. and AL-Hamairy, A.K. Seroepidemiological study for patients with diabetes that infected with Toxoplasma gondii in the Babylon province. International Journal of Innovation and Applied Studies, 2015; 12: 183-189.

. Dubey JP. Infectivity and pathogenicity of Toxoplasma gondii oocysts for cats. J Parasitol. 1996;8]6 [ :957-61.


Refbacks

  • There are currently no refbacks.


 

 
  
 

 

  


About IJSBAR | Privacy PolicyTerms & Conditions | Contact Us | DisclaimerFAQs 

IJSBAR is published by (GSSRR).