FTIR Combined with Chemometrics for Fast Simultaneous Determination of Penicillin and Cephalexin in Pharmaceutical Tablets

Xuân Thanh Bui, Thi Kim Thuong Nguyen, Thi Huyen Doan, Si Hung Le, Thi Thao Ta

Abstract


In this research, the potential of combining chemometrics with FTIR techniques to provide a rapid and simultaneous quantitative analyses method for determination penicillin, cephalexin is studied. Unlike other methods, FTIR is considered as a time saving method due to its non-destructive and simple sample preparation. Due to the similarity of infrared spectral, PLS and PCR couples with spectral treatment techniques are applied to make the calibration model for penicillin and cephalexin determination at the same time. The result is also validated in term of RMSEP and R2 value using validation set. The FTIR combined with PLS method shows the best results.


Keywords


Chemometrics; FTIR method; penicillin; cephalexin.

Full Text:

PDF

References


M. Alcalà, M. Blanco, D. Moyano, N. Broad, N. O’Brien, D. Friedrich, F. Pfeifer, H. Siesler, “Qualitative and quantitative pharmaceutical analysis with a novel handheld miniature near-infrared spectrometer”, J. Near Infrared Spectrosc. 21 (6), pp. 445, 2013,

World Health Organization, “Counterfeit and Substandard Drugs in Myanmar and Viet Nam”. Essential Drugs and Other Medicines , Geneva, 1999

J. D. Campagna, M. C. Bond, E. Schabelman, B.D. Hayes, “The use of cephalosporins in penicillin-allergic patients: a literature review”. J Emerg Med, vol. 42(5), pp. 612-20, 2012.

Vietnamese Pharmacopeia. Edition 2010

B. Simon, G. Hancu, A. Gyéresi, “Application of capillary electrophoresis to the simultaneous determination and stability study of four extensively used penicillin derivatives”. Brazilian Journal of Pharmaceutical Sciences, vol. 50, n. 3, pp. 521-527, 2014.

S. M. Ali , A. A. Elbashir, H. Y. Aboul-Enein, “Spectrocopic methods for analysis of cephalosporins in pharmaceutical formulations,” World Journal of Analytical Chemistry. Vol. 3, No. 1A, pp. 21-32, 2015.

Y. Roggo, P. Chalus, L. Maurer, C. Lema-Martinez, A. Edmond, N. Jent, “A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies”, Journal of Pharmaceutical and Biomedical Analysis, 44, pp. 683-700, 2007.

D. Pavia, “Introduction to spectroscopy : a guide for students of organic chemistry”, Brooks Cole: South Melburne, 2001.

D. Ami, P. Mereghetti, S. M. Doglia, “Multivariate Analysis for Fourier Transform Infrared Spectra of Complex Biological Systems and Processes”. Multivar. Anal. Manag. Eng. Sci. pp.189-220, 2012.

A. Rohman, D. L. Setyaningrum, S. Riyanto, “FTIR spectroscopy combined with partial least square for analysis of red fruit oil in ternary mixture system”, Int. J. Spectrosc., pp.1-5, 2014.

Y. Roggo, P. Chalus, L. Maurer, C. Lema-Martinez, A. Edmond, N. Jent, “A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies”, J. Pharm. Biomed. Anal., 44, pp. 683-700, 2007.

M. J. Lerma-García, G. Ramis-Ramos, J. M. Herrero-Martínez, E. F. Simó-Alfonso, “Authentication of extra virgin olive oils by Fourier-transform infrared spectroscopy”, Food Chem. 118 (1), pp. 78-83, 2010.

A. Rohman, Y. B. Che Man, A. Ismail, H. Puziah, FTIR spectroscopy combined with multivariate calibration for analysis of cod liver oil in binary mixture with corn oil. Int. Food Res. J. 18 (2), 757-761, 2011.


Refbacks

  • There are currently no refbacks.


 
 
  
 

 

  


About IJSBAR | Privacy PolicyTerms & Conditions | Contact Us | DisclaimerFAQs 

IJSBAR is published by (GSSRR).