Study the Therapeutic Effect of Camal Milk on Liver Toxicity Experimentally Developed in White Mice Mus musculus

Asst. Teacher Zinah I. Khaleel, Ahmed H. Ahmed, Reham H. Thamer


This study aimed to investigate the effect of Carbon tetrachloride CCl4 and Camel Milk on histological changes of liver. It was used only (16) mouse . to study the effect of Carbon tetrachloride CCl4 and Camel Milk on changes. The mouse were randomly divided into equal groups as follows. First group was It was narrated orally with 0.1 ml, normal saline. This group was considered as control group .The second group was It was narrated orally with( 0.1 ml) Carbon tetrachloride CCl4 of body weight for . The third group and fourth group It was orally given (0.5 , 1) ml dose respectively of Camel milk for (3 weeks), After treatment with Carbon tetrachloride CCl4 For five days. There was clear effect for Carbon tetrachloride CCl4 on liver, it was caused infiltrative cells presented by lymphocytes and phagocyte, liver cells defect; like edema, necrosis and haemolysis in liver cells, it was found catalytic effect in treated group with Carbon tetrachloride CCl4 and Camel milk liver, It appeared in normal appearance and like the control group. It showed catalytic effect in treated groups with Carbon tetrachloride CCl4 and Camel milk , and little negative in the liver .


Carbon tetrachloride; Camel Milk; histological changes; liver cells.

Full Text:



. ???????? ????? ????? ???????? ???? ????. (1990). ????? ??????? ????????. ????? ??????? ?????? ????? ?????

. Morton, R.H. (1984). Camels for meat and milk production in Sub-Sahara Africa. J. Dairy Sci., 67: 1548-1553.

. Magdi , A.O. Ibrahim , E.A. and Hamid , A.D. (2010) Bio-chemical Changes occurring during fermentation of camel milk by selected bacterial starter cultures. African. J. Bio-tech.9 (43) : 7331-7336.

. - Farah , Z. Rettenmaier , R. and Atkins , D. (1992) Vitamin content of camel milk . Internat. J. Vit. Nutr. Res. 62 :30-33

. Zagorski, O. ; Maman, A. ; Yafee, A. ; Meisles, A. ; Van creveld, C. and C. and Yagil, R. (1998). Insulin in milk a comparative study. International . J. Animal science., 13: 241-244 .

. Agrawal, R.p ; Beniwal , R.; Sharma, S.; Kochar, D.k., Tuteja, F.C. ;Ghorui, S.K. and Sahani, M.S. (2005a). Effect of raw camal milk in type l diabetic patients : 1 year randomized study. J. camel Practics and Research., 12(1) : 27-35 .

. El-Agmay, E.l. Ruppannes , R., Ismail, A. (1992). Antibacterial and antiviral activity of camel milk protective proteins . J.Dairy Res.,59:169-175 .

. Rhoads, C.S. and Elmor, J.G. (2000). Early detection of breast cancer. A review of screening modalities primary care and cancer., 20 : 11-14 .

. Latteef , R.H. ;The effects of ethyl alcohol on implantation and fecunding in mice , university of Tikrit , (2001), Tikrit, Iraq.

. Humason,G.L.(1978).Animal tissue techniques , W.H. freeman Company,San Francisco .

. Mion, F.; Geloen, A. ; Agosto, E. and Minaire, Y.(1996).Carbon tetrachloride-induced cirrhosis in rats influence of the acute effects of the toxin on glucose metabolism .Hepatology,23(3):582-588.

. Megli, F. M. and Sabatini, K. (2004).Mitochondrial phospholipides bilayer structure is ruined after livre oxydative injure in vivo FEBS lettres.573(1-3):68-72.

. Hassan-Khabbar, S. ; Cottart, C. H. ; Wendum, D. ; Vibert, F. ; Clot,J. P. ; Savouret, J. F. ; Conti, M. ; Nivet-Antoine, V. (2008) .Postischemic treatment by trans-resveratrol in rat liver ischemiareperfusion:a possible strategy in liver surgery. LiverTranspl; 14: 451-459.

. Muriel, P. ; Alba, N. ; Perez-Alvarez, V. M. ; Shibayama, M. and Tsutsumi, V. (2001).Kupffer cell inhibition prevents hepatic lipi peroxidation and damage induced by carbon tetrachloride. Comp . Biochem, and Physiology. 130:219-226.

. Yong Diao; Xiao-Feng Zhao; Jun-Sheng Lin; Qi-Zhao Wang and Rui-An Xu. (2011). Protection of the liver against CCl4-induced injury by intramuscular electrotransfer of a kallistatin-encoding plasmid World J Gastroenterol ; 17(1): 111-117.

. Al-Ghamdi ,M. S. (2003). Protective effect of Nigella sativa seeds against carbon tetrachloride- induced liver damage. Am J. Chin Med;31(5):721-8.

. Hamers-Casterman, C. ; Atarouch, T.; Muyldermans, S.; Bendolman, N. and Hamers , R. (1993). Naturally occurring antibodies devoid of light chains. Nature. 363 - .446- 448 .

. Jassim, S.A.A. and Naji, M.A.(2001). Camel immune system and activity of milk . Biologist 48:26872.

. Kappeler, S. (1998) Compositional and structural analysis of camel milk proteins with emphasis on protective proteins. Ph.D. Diss. ETH No. 12947, Zurich.

. Al-Mahdy , O. El-Fakharany , E. El-Dabba , E. and Red-wan , E. (2011) Examination of the activity of camel milk casein against Hepatitis C virus (Genotype-4 a) and its apoptotic potential in Hepatoma and Hela cell line . Hepat. Mon. 11 (9):724-730.


  • There are currently no refbacks.





About IJSBAR | Privacy PolicyTerms & Conditions | Contact Us | DisclaimerFAQs 

IJSBAR is published by (GSSRR).