Leptin is Not Associate with Maternal Fat Mass on the Third Trimester of Pregnancy


Leptin was initial known as adipocyte product link to the obese gene. Pregnancy is a physiologic leptin resistance state. The placenta is reported to synthesize and release leptin too. This study is to observe the association between maternal serum leptin with maternal body fat mass on the third trimester of pregnancy. Leptin was measured by ELISA from the serum of maternal on median pregnancy age 30 weeks. Maternal body fat mass was measured by bioelectrical impedance analyzing (BIA) methods.

The mean of maternal fat mass is, M= 20,1 kg, SD= 5,2, minimum 10,6 kg and maximum 35,3 kg. Leptin, M= 46,9 gr/L, SD= 32,6, minimum 5,8 gr/L and maximum 146,7 gr/L. Univariate analysis showed, in third trimester of pregnancy, maternal serum leptin could not predict the maternal fat mass appropriately, SS 14,007, MS 4,67, F (3, 66) = 0,17, p 0,92, partial ?2 0,01. This current study shows, leptin level is higher during the third trimester of pregnancy and not associate with maternal fat mass. In the third trimester of pregnancy, maternal serum leptin could not predict the maternal fat mass precisely.


pregnancy; leptin; fat mass; placenta.

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Lewandowski K, Horn R, OCallaghan CJ, et al., 1999. Free leptin, bound leptin, and soluble leptin receptor in normal an diabetic pregnancies. J Clin Endocrinol Metab, Volume 84, pp. 300-306.

Augustine RA, Grattan DR. 2008. Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology; 149: 1049-1055.

Herrera E, Lasuncion MA, Palacin M, Zorzano A, Bonet B. 1991. Intermediary metabolism in pregnancy. Diabetes; 40: 83-88.

Ladyman SR, Augustine RA, Grattan DR. 2010. Hormone interactions regulating energy balance during pregnancy. J Neuroendocrinol 22 : 805-817.

Faas MM, Melgert BN, de Vos P. 2010. A Brief Review on How Pregnancy and Sex Hormones Interfere with Taste and Food Intake. Chem. Percept. ; 3:5156.

Trujillo ML, Spuch C, Carro E, Senaris R., 2011. Hyperphagia and central mechanisms for leptin resistance during pregnancy. Endocrinology, Volume 152, pp. 1355-1365.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM.1994 Positional cloning of the mouse obese gene and its human homologue. Nature; 372: 425-432.

Friedman JM. 2011. Leptin and regulation of body weight. Keio J Med ; 60: 1-9.

Knight ZA, Hannan KS, Greenberg ML, Friedman JM, 2010. Hyperleptinemia is required for the development of leptin resistance. PLoS ONE, 5(6), p. e11376.

Remmers F, van der Waal-Delemare HA. Developmental programming of energy balance and its hypothalamic regulation. Endocrine Reviews 2011; 32: 272-311.

Ladyman SR, Fieldwick DM, Grattan DR. 2012. Suppression of leptin-induced hypothalamic JAK/STAT signaling and feeding response during pregnancy in the mouse. Reproduction 144: 83-90.

Margetic S, Gazzola C, Pegg GG, Hill RA. 2002. Leptin: a review of its peripheral actions and interactions. International Journal of Obesity; 26: 1407-1433.

Mantzoros CS, Mgkos F, Brinkoetter M, et al. 2011. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab;301 : E 567-E584.

Van der Wijden CL, van der Waal- Delemare HA, van Mechelen W, van Poppel MNM. 2013. The concurrent validity between leptin, BMI, and akin folds during pregnancy and the year after. Nutrition & Diabetes ;3 : e86 ( 6 pages).

Ajala OM, Ogunro PS, Elusanmi GF, Ogunyemi OE, Bolarinde AA.2013 Changes in serum leptin during phases of menstrual cycle of fertile women: relationship to age groups and fertility. Int J Endocrinol Metab.; 11(1): 27-33.

Friedman JM, Halaas JL. 1998. Leptin and the regulation of body weight in mammals. Nature ; 395 : 763 770.

Farooqi IS, Wangensteen T, Collins S, et al. Clinical and Molecular Genetic Spectrum of Congenital Deficiency of the Leptin Receptor. N Engl J Med 2007;356:237-47.

McCartney CR, Marshall JC. Neuroendocrinology of reproduction. In: Straus III JF, Barbieri RL (Eds). Yen & Jaffes reproductive endocrinology: physiology, pathophysiology, and clinical management. 7th ed. Elsevier Saunders. Philadelphia. 2014.pp 3 26.

Mantzoros CS, Mgkos F, Brinkoetter M, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab 2011;301 : E 567-E584.

Guo X, Roberts MR, Becker SM, et al. Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. MucosalImmunology 2011 ; 4(3) :294-303.

Gainsford T, Willson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc. Natl. Acad. Sci. USA 1996; 93:1456414568.

Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W. A role for leptin and its cognate receptor in hematopoiesis. Current Biology 1996; 6 (9):11701180.

Laharrague P, Larrouy D, Fontanilles AM, et al. High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J. 1998; 12: 747-752.


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