Minimization of Side Effects of Anti-Tuberculosis Drugs by Using Supplements Honey in the Region of Gorontalo City Health Center in 2016

Wenny Ischak, Imelda Appulembang, La banudi


The world Health Organization (World Health Organization) recommends programs to cope with TB disease is by the method Strategy Directly Observed Therapy (DOT'S). Incidence of Adverse effects of Anti-Tuberculosis Drugs (OAT) is a problem that many complained of tuberculosis. The purpose of this study see the effect of using honey supplement to the reduction of side effects of the drug on patients with tuberculosis in Puskesmas. The research type experimental study Randomized Clinical Trial (RCT) design with Randomized Pre-Post Test Control Group Design. Total sample used by 60 divided into intervention group 30 samples are given 30 ml Honey + OAT and a control group of 30 samples only OAT. Data were analyzed by paired t test and unpaired t test. The results showed there was a difference a reduction in the average value of the side effects significantly in the intervention group compared to the group that is 14.1 dick that is only reduced 2.5 mean a side effect of the previous amount. Supplementation of honey can be influential in the reduction of side effects in patients tuberculosis OAT.


Tuberculosis; honey; side effects.

Full Text:



Erawatyningsih P. & Heru S. E. (2012). Faktor-Faktor yang Mempengaruhi Ketidakpatuhan Berobat pada Penderita Tuberkulosis Paru. Jurnal Berita Kedokteran Masyarakat(BKM), 25, 117.

Hermayanti D. (2010). Studi Kaus Drop Out Pengobatan Tubekulosa di Puskesmas KodyaMalang. Jurnal universitas Muhammadiyah Malang

WHO.(2011). WHO Report 2011 global Tuberculosis Control.ional Guide for National Tuberculosis Programmes. WHO repport, Geneva

Kementerian Kesehatan. (2013). Riset Kesehatan Dasar 2013. jakarta: kementerian kesehatan RI.

Kurniati L. (2010). Angka Konversi Penderita Tuberkulosis Paru yang Diobati dengan ObatAntituberkulosis (OAT) Paket Kategori Satu di BP4 Garut. MKB Vol. 42 No.1, 2010

Marx F. M. et al. (2012). The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting: a retrospective cohort study.

Cavalcante S. et al. (2010). Community-randomized trial of enhanced DOTS for tuberculosiscontrol in Rio de Janeiro, Brazil. The international journal of tuberculosis and lungdisease: the official journal of the International Union against Tuberculosis and LungDisease, 14, 203.

Sharma et al. (2008). Influence of honey on adverse reactions due to anti-tuberculosis drugsin pulmonary tuberculosis patients. Cont. J. Pharm. Tox. Res, 2, 6-11

Sinha et al. (2013). Adverse drug reactions in tuberculosis patients due to directly observedtreatment strategy therapy: Experience at an outpatient clinic of a teaching hospital inthe city of Imphal, Manipur, India. The Journal of Association of Chest Physicians,1(2), 50.

Sari dkk. (2014). Studi Monitoring Efek Samping Obat Antituberkulosis Fdc Kategori 1 DiProvinsi Banten Dan Provinsi Jawa Barat. Media Litbangkes Vol. 24 No. 1, Mar 2014,28-35

Rian. (2010). Pengaruh Efek Samping Obat Anti Tuberkulosis Terhadap Kejadian Default DiRumah Sakit Islam Pondok Kopi Jakarta Timur Januari 2008Mei 2010. TesisUniversitas Indonesia diakses pada tanggal 19 oktober 2014

Depkes RI. (2010). Lembar Fakta Tuberkulosis. Jakarta

George S. & Benny P. (2010). A Review on the Medicinal Significance of Common Fruits .International Journal Of Biomedical Research And Analysis 2010; 1 (2): 60 -64

Bogdanov S. (2010). Honey as Nutrient and Functional Food. Book of Honey, Chapter 7: 1-28

Rahmayuni, Faizah H., & Fifin N. 2013. Penambahan Madu dan Lama Fermentasi Susu Fermentasi Kacang Merah. SAGU Vol. 12 No.1, Maret 2013, 25-33

Suranto A. (2004). Khasiat dan Manfaat Madu Herbal. PT AgroMedia Pustaka: Depok

Gay and Diehl. (1996) Research Methods for Business and Management

Robbins, S L, Contran, R S, & Kumar (2003), Dasar Patologi penyakit, edisi 8, ECG, Jakarta


  • There are currently no refbacks.





About IJSBAR | Privacy PolicyTerms & Conditions | Contact Us | DisclaimerFAQs 

IJSBAR is published by (GSSRR).