The Relationship between Epicardial Adipose Tissue Thickness with Severity of Coronary Artery Disease in Indonesia

Abdul Hakim Alkatiri, Syakib Bakri, Ilhamjaya Patellongi, Mirnawati Mappiare

Abstract


Epicardial adipose tissue (EAT), which is thought to be a componentof visceral adiposity, is associated with the metabolic syndrome and considered as an indicator of cardiovascular risk.Correlation of EAT with coronary artery disease (CAD) in Indonesia is unknown. To address this issue, we examined the relationship between EAT thickness with severity of coronary lesion in Indonesian patients with CAD. Results revealed that one hundred and thirty one consecutive patients who underwent transthoracic echocardiography (TTE) anddiagnostic coronary angiography were studied. The EAT thickness on the free wall of the right ventriclewas measured at end-diastole from the parasternal long-axis views. Coronary angiogramswere analyzed for severity of coronary artery disease using modified Gensini score. Accordingly, we classified the study population into two angiographic groups: patients with non-severe CAD (Gensini score ?13) and patients with severe CAD (Genisini score >13). There were no significant differences between the groups with respect to anthropometric measurements, including body mass index and waist circumference (p=0.473 and 0.947, respectively).

The patients in severe CAD group had greater EAT thickness compared with non-severe CAD group (mean EAT thickness was 8.52.4 mm and 6.12.5 mm, respectively with p<0.001).EAT thickness of >7.0 mm had an 78.2 % sensitivity and an 71.7% specificity (ROC area of 0.800, p<0.001, 95% CI [0.72-0.88] for predicting severe CAD. In conclusions EAT thickness was significantly correlated with the severity of CADin Indonesian patients with stable CAD.


Keywords


epicardial adipose tissue; coronary artery disease; echocardiography; Indonesia.

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References


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