Relation Expression of Eestrogen Reseptor and Ki67 in Invasive Ductal Carcinoma Breast Cancer

Christian B, Daniel Sampepajung, Prihantono Prihantono, Berti Nelwan, Burhanuddin Bahar


Estrogen are potent mitogenic stimuli that share important properties in the control of cellular proliferation. Increased expression and/or activity of estrogen reseptor (ER) result in aberrant activation of downstream signaling pathways including cAMP/PKA, MAPK/ERK and PI3K/AKT. The importance of estrogen and as a signaling axis in cancer development, progression and metastasis is highlighted by its effects on cancer cells, notably proliferation.  But, all mechanism of this proliferation action ER and Ki67 not complete clear yet. The study aims to explore the coupling between the signaling cascades of estrogen receptors  to celular proliferation (Ki67). This research used an exploration analitik with  cross sectional design, 59 specimen pathologi were explore with Immunohistochemia (IHC) examine to asses expression of Estrogen reseptor and Ki67 in invasif ductal breast cancer. To asses corelation beetwen ER and  Ki67 with Chi-Square Test. Result found that the IHC examation show that propotion   ER. : 35/ 55 (63 %), Ki67 :32/55 ( 58 %) in invasive ductal breast cancer. Correlated beetwen ER  and  Ki67 expression  no significant   p>0.05 in invasif ductal breast cancer. In conclution, ER does not play a significant role in celluler proliferation in Invasive breast cancer.



Expression ER and Ki67; Carcinoma breast cancer.


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