Synthesis and Evaluation of New Series of 1,4-Dihydropyridine Derivatives as Anticancer Agents

Anil Kumar Garige, Achaiah Garlapati

Abstract


1,4-dihydropyridine derivatives represent one of the important classes of compounds possessing a wide variety of biological activities including anticancer activity. In the present study, (4-Alkyl/Aryl-1-substituted 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxilicacid, 3,5-bis [2(aminothioxomethyl)hydrazides]) (6 a-l) were synthesized by the reaction of 4-alkyl/aryl-3,5-dicarboalkoxy-2,6-dimethyl-1,4-dihydropyridines (4 a-l) with thisemicarbazide and evaluated for their anti-cancer properties.

All the synthesized compounds were characterized by IR, NMR and Mass spectra and were screened to evaluating for anticancer activity against three cell lines (MCF-7, HeLa and Hep G2) by using MTT assay method. The results showed that compounds 6j and 6l showed significant cytotoxicity with IC50 values ranging from 56M - 74M.


Keywords


Cancer; 1,4-Dihydropyridines; MTT assay; Thiosemicarbazide.

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References


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