Microvascular Changes in Patients with Psoriatic Arthritis as Shown in Nail Fold Capillaroscopy

Alireza Rajaei, Pooneh Dehghan

Abstract


P-value less than 0.05 was considered statistically significant.Participants had a mean age of 44.2512.20; 34 patients (62.9%) were female and 20 (37.03%) were male. Tortuosity of capillaries was observed in 54 cases and angiogenesis in 40 patients. Early scleroderma pattern was observed in 15 cases (27.77 %) and 39 patients fell into the normal category(72.22%). The morphological abnormalities, except angiogenesis and avascular area, was significantly more frequent in patients with scleroderma pattern, compared with patients with normal pattern (P<0.05).

As a conclusion we can say that Nail fold capillaroscopy, considered by many expert the gold standard method of microvascular investigation play an important role in evaluation and follow up of patients with psoriasis and the results potentially affect prognosis.

Microvascular changes play an important role in the pathogenesis of many manifestations and complications of psoriatic arthropathy. Early diagnosis play an important role in the management of the disorder and probable long term complications. Nail fold Video Capillaroscopy (NVC) is an effective, non-invasive, easily accessible and cheap method of microvascular investigation. The aim of this study was to evaluate nail fold capillaroscopic findings in patients with psoriatic arthritis. This cross-sectional study was conducted in Ressalat Hospital Nail Fold Capillaroscopic Center and capillaroscopic findings of 54 patients referred to the center between 2011 and 2014were reviewed. Nail fold capillaroscopy was performed on all fingers (10 fingers for each patient). Microvascular architecture; capillary distribution, morphology and density; efferent/afferent limb ratio, sub-papillary venular plexus and morphological abnormalities were recorded and reviewed. Results were reported as scleroderma pattern, nonspecific morphological abnormalities and normal. Results were analyzed qualitatively and quantitatively using SPSS 21 software. "Chi square" test was used to analyze the relationships between variables.


Keywords


Psoriasis; Nail fold Video Capillaroscopy (NVC); Scleroderma pattern.

Full Text:

PDF

References


. J.M.H Moll, V.Wright. Psoriatic arthritis. Semin Arthritis Rheum 1973; 3: 55-78.

. D.Veale , S.Rogers, O.Fitzgerald. Classification of clinical subsets in psoriatic arthritis. Br J Rheumatol 1994; 33: 133-8.

. G.M. Klammer, N.A. Soter, D.J.Gibson, P.H.Schur. Psoriatic arthritis clinical, immunologic and HLA study of 100 patients. Semin Arthritis Rheum 1979; 9: 75-97.

. I.M. Braverman, A.Yen. Ultrastructure of the capillary loops in the dermal papillae of psoriasis. J Invest Dermatol 1977; 68: 53-60.

. S.P.Barton, M.S. Abdullah, R.Marks. Quantification of micro- vascular changes in the skin in patients with psoriasis. Br J Dermatol 1992; 126: 569-74.

. D. Creamer, M.Allen, A.Souza, J.N.W.N.Barker. Localization of endothelial proliferation and microvasculature expansion in active plaque psoriasis. Br J Dermatol 1997; 136: 859-65.

. LR.Espinoza, FB.Vasey, CG. Espinoza et al. Vascular changes in psoriatic synovium. A light and electron microscopic study. Arthritis Rheum 1982; 25: 677-84.

. HR. Maricq, EC. LeRoy, WA. D'Angelo et al. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 1980; 23: 183-9.

. D. Blockmans, G. Beyens, R.Verhaeghe. Predictive value ofnailfold capillaroscopy in the diagnosis of connective tissue disease. Clin Rheum 1996; 15: 148-53.

. Y. Kabaskal, DM. Elvins, EFJ. Ring, NJ. McHugh. Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann Rheum Dis 1996; 55: 507-12.

. M. Bukhari, AL. Herrick, T. Moore et al. Increased nailfold capillary dimensions in primary Raynaud's phenomenon and systemic sclerosis. Br J Rheumatol 1996; 35: 1127-31.

. W.Redisch, EJ. Messina, G.Hughes, C.McEwen. Capillaroscopic observations in rheumatic diseases. Ann Rheum Dis 1970; 29: 244-53.

. D.Zaric, OJ.Clemmensen, AM.Worm, D.Stahl. Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis. Dermatologica 1982; 164: 10-14.

. T.Ohtsuka, A.Yamakage, Y.Miyachi. Statistical definition of nailfold capillary pattern in patients with psoriasis. Int J Dermatol 1994; 33: 779-82.

. D.Zaric D, AM.Worm, D.Stahl, OJ. Clemmensen. Capillary micro-scopy of the nailfold in psoriatic and rheumatoid arthritis. Scand J Rheumatol 1981; 10: 249-52.

. W.Grassi, P.Core, G.Carlino, C.Cervini. Nailfold capillary permeability in psoriatic arthritis. Scand J Rheumatol 1992; 21: 226-30.

. BN.Statham, NR.Rowell. Quantification of the nailfold capillary abnormalities in systemic sclerosis and Raynaud's syndrome. Acta Derm Venereol (Stockh) 1986; 66: 139-43.

. P.Zufferey, M.Depairon, AM.Chamot, M.Monti. Prognostic significance of nailfold capillary microscopy in patients with Raynaud's phenomenon and scleroderma pattern abnormalities. A six year follow-up study. Clin Rheum 1992; 11: 536-41.

. T.Ohtsuka, T.Tamura, A.Yamakage, S.Yamazaki. The predictive value of quantitative nailfold capillary microscopy in patients with undifferentiated connective disease. Br J Dermatol 1998; 139: 622-9.

. N.Zaias. Psoriasis of the nail. A clinical-pathologic study. Arch Dermatol 1969; 99: 567-79.

. M.Bhushan, T.Moore, A.L.Herrick, C.E.M.Griffiths. Nailfold video capillaroscopy in psoriasis. British Association of Dermatologists, 2000; 142, 1171-1176.


Refbacks

  • There are currently no refbacks.


 

 
  
 

 

  


About IJSBAR | Privacy PolicyTerms & Conditions | Contact Us | DisclaimerFAQs 

IJSBAR is published by (GSSRR).