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High Density Lipoprotein Cholesterol Predicts Triglycerides Level in Three Distinct Phases of Blood Pressure

Wan Muhamad Amir, Mohd Shafiq


Atherosclerosis is also known as arteriosclerotic vascular disease. It is a condition when the arteries become narrowed and hardened due to the excessive of plaque which is made of fat, cholesterol, calcium and other substances. This study aims to examine the regulatory roles of triglycerides level in three distinct phases of blood pressure. One way ANOVA analysis is used to test the differences among the three distinct conditions, which is normal, borderline and hypertensive. The systolic blood pressure highly significant different (F (2, 997) = 3.595, p = 0.028) across the three distinct phases. We also applied multiple linear regression (MLR) method in order to assess the associated factor of triglycerides level according to the three distinct phases as discussed in ANOVA analysis. The statistical analyses revealed that there are partially significant differences due to the different distinct phases of blood pressure.  The associated factors of triglycerides were total of cholesterol, high density lipoprotein cholesterol and proconvertin. All the variables were statistically significant across the three main conditions. These initial findings from three distinct phases denote that there a negative association between triglycerides level and HDL cholesterol. This finding shows that the factor of triglycerides level might be a valuable marker of atherosclerosis in three distinct phases of blood pressure.



Triglycerides; ANOVA; Normal, Borderline and Hypertensive blood pressure; Multiple linear regression


R.W. Alexander, “Oxidative Stress and the Mediation of Arterial Inflammatory Response: A New Perspective,” Hypertension, 1995, vol. 25, pp.155-161.

E. Bøg-Hansen, U. Lindblad, J. Ranstam, A. Melander, and L. Råstam, “Impaired glucose metabolism and obesity in Swedish patients with borderline isolated systolic hypertension: Skaraborg Hypertension and Diabetes Project,” Diabetes Obesity Metabolism, 2001, vol. 3, no. 1, pp. 25-31.

E.J. Boyko, D.L. Leonetti, R.W. Bergstrom, L. Newell-Morris, and W.Y. Fujimoto, “Visceral Adiposity, Fasting Plasma Insulin, and Blood Pressure in Japanese Americans,” Diabetes care, 1995, vol. 18, no. 2.

B. Falkner, S. Hulman, and H. Kushner, “Insulin-Stimulated Glucose Utilization and Borderline Hypertension in Young Adult Blacks,” Hypertension, 1993, vol. 22, no. 1.

P. Henry, F. Thomas, A. Benetos, and L. Guiz, “Impaired Fasting Glucose, Blood Pressure and Cardiovascular Disease Mortality,” Hypertension, 2002, vol. 40, pp. 458-463.

M. Egger, G.D. Smith, D. Pfluger, E. Altpeter, and P.C. Elwood, “Triglyceride as a risk factor for ischemic heart disease in British men: effect of adjusting for measurement error,” Atherosclerosis, 1999, vol. 143, pp. 275-284.

K.H. Bonaa, and D.S. Thelle, “Association between Blood Pressure and Serum Lipids in a Population the Tromsa Study,” Circulation, 1991, vol. 83, pp.1305-1314.

S. Lindeberg, B. Ahren, A. Nilsson, L. Cordain, P. Nilsson-Ehle, and B. Vessby, “Determinants of serum triglycerides and high density lipoprotein cholesterol in traditional Trobriand Islanders: the Kitava Study,” Scand J Clin Lab Invest, 2003, vol. 63, pp. 175–180.

U.S. Department of Health and Human Services, JNC Express, “The Seventh Report on the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure Washington DC: National Institutes of Health,” Hypertension, 2003, vol. 42, pp. 1206-1252.

W.D. Dupont. and W.D. Plummer, “PS power and sample size program available for free on Internet,” Controlled Clinical Trials, 1997, vol. 18, pp. 274.

W.M.A.W. Ahmad, N.A. Aleng, N. Mohamed and Z. Ali, “Preliminary Estimation of Risk That Associated With the Prevalence of Tuberculosis,” International Journal of Advance in Engineering Science and Technology, 2012, vol. 2, no. 10, pp. 6-12.

R. Byori, M. Kobayashi, and S. Uesugi, “The role of hypertension as a risk factor of atherosclerosis,” The Japanese Journal of Clinical Pathology, 1995, vol. 43, no. 2, pp. 104-110.

W.M.A.W. Ahmad, N.A. Aleng and N.A. Halim, “Male and Female Differences in the High Density Lipoprotein (HDL) and Progression of Diabetic Disease in Coronary Heart Disease Patients,” Applied Mathematical Sciences, 2013,vol.7, no.37, pp. 1825-1838.

W.M.A.W. Ahmad, N. Mohamed, N. A. Aleng, and Z. Ali, “Influence of Hypertension and Diabetes Mellitus on Family History of Heart Attack in Male Patients,” Applied Mathematical Sciences, 2012,vol 6, no 66, pp. 3259-3266.

C.L. Hsu, Y.L. Liao, S.C. Lin, and P. Chou, “Adiponectin level predicts HDL-cholesterol level in type 2 diabetes,” The Open Atherosclerosis and Thrombosis Journal, 2012, vo. 5, pp. 1-5.

T.M. Maddox, “Atherosclerosis and High Blood Pressure,” In, 2012,

R. Sharma, S. Prudente, F. Andreozzi, C. Powers, G. Mannino, S. Bacci, E.V. Gervino, T.H. Hauser, E.

Succurro, L. Mercuri, E.H. Goheen, H. Shah, V. Trischitta, G. Sesti, and A. Doria, “The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects,” Atherosclerosis, 2011, vol. 216, pp.157–160.

J. Jeppesen, H.O. Hein, P. Suadicani, and F. Gyntelberg, “High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease,” Hypertension, 2000, vol.36, pp.226-232.

M. Miller, A. Seidler, A. Moalemi, and T.A. Pearson, “Normal Triglyceride Levels and Coronary Artery Disease Events: The Baltimore Coronary Observational Long-Term Study,” Am J Cardiol, 1998,vol. 31, pp. 1252–1257.

W.M.A.W. Ahmad, W.A.A.W. Amin, N.A. Aleng and N. Mohamed, “Some practical guidelines for effective sample-size determination in observational studies,” Aceh International Journal of Science and Technology, 2012, vol. 1, no. 2, pp. 51-53.

F. Tesfaye, N.G. Nawi, H.V. Minh, P. Byass, Y. Berhane, R. Bonita, and S. Wall, “Association between body mass index and blood pressure across three populations in Africa and Asia. Journal of Human,” Hypertension, 2007, vol. 21, pp. 28–37.

C.P. Lucas, J.A. Estigarribia, L.L. Darga, and G.M. Reaven, “Insulin and Blood Pressure in Obesity,” Hypertension, 1985, vol. 7, pp.702-706.

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